TRIM56 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0051607Biological processdefense response to virus
GO_1901224Biological processpositive regulation of non-canonical NF-kappaB signal transduction
GO_0032728Biological processpositive regulation of interferon-beta production
GO_0006513Biological processprotein monoubiquitination
GO_0045089Biological processpositive regulation of innate immune response
GO_0060340Biological processpositive regulation of type I interferon-mediated signaling pathway
GO_0032479Biological processregulation of type I interferon production
GO_0034340Biological processresponse to type I interferon
GO_0070534Biological processprotein K63-linked ubiquitination
GO_0045087Biological processinnate immune response
GO_0005829Cellular componentcytosol
GO_0005737Cellular componentcytoplasm
GO_0061630Molecular functionubiquitin protein ligase activity
GO_0004842Molecular functionubiquitin-protein transferase activity
GO_0005515Molecular functionprotein binding
GO_0008270Molecular functionzinc ion binding
GO_0003723Molecular functionRNA binding

IV. Literature review

[source]
Gene nameTRIM56
Protein nameE3 ubiquitin-protein ligase TRIM56 (EC 2.3.2.27) (RING finger protein 109) (Tripartite motif-containing protein 56)
Tripartite motif containing 56
SynonymsRNF109
DescriptionFUNCTION: E3 ubiquitin-protein ligase that plays a key role in innate antiviral immunity by mediating ubiquitination of CGAS and STING1 . In response to pathogen- and host-derived double-stranded DNA (dsDNA), targets STING1 to 'Lys-63'-linked ubiquitination, thereby promoting its homodimerization, a step required for the production of type I interferon IFN-beta (By similarity). Also mediate monoubiquitination of CGAS, thereby promoting CGAS oligomerization and subsequent activation . Promotes also TNFalpha-induced NF-kappa-B signaling by mediating 'Lys-63'-linked ubiquitination TAK1, leading to enhanced interaction between TAK1 and CHUK/IKKalpha . Independently of its E3 ubiquitin ligase activity, positive regulator of TLR3 signaling. Potentiates extracellular double stranded RNA (dsRNA)-induced expression of IFNB1 and interferon-stimulated genes ISG15, IFIT1/ISG56, CXCL10, OASL and CCL5/RANTES . Promotes establishment of an antiviral state by TLR3 ligand and TLR3-mediated chemokine induction following infection by hepatitis C virus . Acts as a restriction factor of Zika virus through direct interaction with the viral RNA via its C-terminal region . .

AccessionsENST00000306085.11 [Q9BRZ2-1]
C9JI91
ENST00000467847.1
Q9BRZ2
ENST00000412507.1
A0A0D9SF19