TRIM32 report

I. Expression across cell types

II. Expression across tissues

sc-RNAseq data

Insufficient scRNA-seq data for expression of TRIM32 at tissue level.

III. Associated gene sets

GO_0016567Biological processprotein ubiquitination
GO_2000786Biological processpositive regulation of autophagosome assembly
GO_1902018Biological processnegative regulation of cilium assembly
GO_1903265Biological processpositive regulation of tumor necrosis factor-mediated signaling pathway
GO_0061564Biological processaxon development
GO_0000209Biological processprotein polyubiquitination
GO_0046716Biological processmuscle cell cellular homeostasis
GO_0051091Biological processpositive regulation of DNA-binding transcription factor activity
GO_0048147Biological processnegative regulation of fibroblast proliferation
GO_0030307Biological processpositive regulation of cell growth
GO_0045862Biological processpositive regulation of proteolysis
GO_0000045Biological processautophagosome assembly
GO_1903886Biological processpositive regulation of chemokine (C-C motif) ligand 20 production
GO_0045087Biological processinnate immune response
GO_0006511Biological processubiquitin-dependent protein catabolic process
GO_2000147Biological processpositive regulation of cell motility
GO_0050769Biological processpositive regulation of neurogenesis
GO_0009411Biological processresponse to UV
GO_0034144Biological processnegative regulation of toll-like receptor 4 signaling pathway
GO_0045787Biological processpositive regulation of cell cycle
GO_0034612Biological processresponse to tumor necrosis factor
GO_0010994Biological processfree ubiquitin chain polymerization
GO_0042594Biological processresponse to starvation
GO_0051092Biological processpositive regulation of NF-kappaB transcription factor activity
GO_0045732Biological processpositive regulation of protein catabolic process
GO_0070936Biological processprotein K48-linked ubiquitination
GO_0045893Biological processpositive regulation of DNA-templated transcription
GO_0030335Biological processpositive regulation of cell migration
GO_0007014Biological processactin ubiquitination
GO_0010508Biological processpositive regulation of autophagy
GO_0043123Biological processpositive regulation of canonical NF-kappaB signal transduction
GO_1902230Biological processnegative regulation of intrinsic apoptotic signaling pathway in response to DNA damage
GO_0070534Biological processprotein K63-linked ubiquitination
GO_0051155Biological processpositive regulation of striated muscle cell differentiation
GO_1903883Biological processpositive regulation of interleukin-17-mediated signaling pathway
GO_0044790Biological processsuppression of viral release by host
GO_0001894Biological processtissue homeostasis
GO_0045666Biological processpositive regulation of neuron differentiation
GO_0006979Biological processresponse to oxidative stress
GO_0032897Biological processnegative regulation of viral transcription
GO_0045444Biological processfat cell differentiation
GO_0005739Cellular componentmitochondrion
GO_0005813Cellular componentcentrosome
GO_0005863Cellular componentstriated muscle myosin thick filament
GO_0005783Cellular componentendoplasmic reticulum
GO_0005829Cellular componentcytosol
GO_0005776Cellular componentautophagosome
GO_0005737Cellular componentcytoplasm
GO_0005634Cellular componentnucleus
GO_0061630Molecular functionubiquitin protein ligase activity
GO_0031369Molecular functiontranslation initiation factor binding
GO_0030957Molecular functionTat protein binding
GO_0017022Molecular functionmyosin binding
GO_0042802Molecular functionidentical protein binding
GO_0030674Molecular functionprotein-macromolecule adaptor activity
GO_0008270Molecular functionzinc ion binding
GO_0003723Molecular functionRNA binding
GO_0004842Molecular functionubiquitin-protein transferase activity
GO_0003713Molecular functiontranscription coactivator activity
GO_0005515Molecular functionprotein binding
GO_0043130Molecular functionubiquitin binding

IV. Literature review

[source]
Gene nameTRIM32
Protein nameRING-type E3 ubiquitin transferase (EC 2.3.2.27)
E3 ubiquitin-protein ligase TRIM32 (EC 2.3.2.27) (72 kDa Tat-interacting protein) (RING-type E3 ubiquitin transferase TRIM32) (Tripartite motif-containing protein 32) (Zinc finger protein HT2A)
SynonymsHT2A
DescriptionFUNCTION: E3 ubiquitin ligase that plays a role in various biological processes including neural stem cell differentiation, innate immunity, inflammatory resonse and autophagy . Plays a role in virus-triggered induction of IFN-beta and TNF-alpha by mediating the ubiquitination of STING1. Mechanistically, targets STING1 for 'Lys-63'-linked ubiquitination which promotes the interaction of STING1 with TBK1 . Regulates bacterial clearance and promotes autophagy in Mycobacterium tuberculosis-infected macrophages . Negatively regulates TLR3/4-mediated innate immune and inflammatory response by triggering the autophagic degradation of TICAM1 in an E3 activity-independent manner . Plays an essential role in oxidative stress induced cell death by inducing loss of transmembrane potential and enhancing mitochondrial reactive oxygen species (ROS) production during oxidative stress conditions . Ubiquitinates XIAP and targets it for proteasomal degradation . Ubiquitinates DTNBP1 (dysbindin) and promotes its degradation . May ubiquitinate BBS2 . Ubiquitinates PIAS4/PIASY and promotes its degradation in keratinocytes treated with UVB and TNF-alpha (By similarity). Also acts as a regulator of autophagy by mediating formation of unanchored 'Lys-63'-linked polyubiquitin chains that activate ULK1: interaction with AMBRA1 is required for ULK1 activation . Positively regulates dendritic branching by promoting ubiquitination and subsequent degradation of the epigenetic factor CDYL . .; FUNCTION: (Microbial infection) May play a significant role in mediating the biological activity of the HIV-1 Tat protein in vivo . Binds specifically to the activation domain of HIV-1 Tat and can also interact with the HIV-2 and EIAV Tat proteins in vivo . .

AccessionsENST00000373983.2
ENST00000411410.1
Q5JVY0
Q13049
ENST00000450136.2