TRIM13 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0016567Biological processprotein ubiquitination
GO_0045087Biological processinnate immune response
GO_0051865Biological processprotein autoubiquitination
GO_0051092Biological processpositive regulation of NF-kappaB transcription factor activity
GO_0045893Biological processpositive regulation of DNA-templated transcription
GO_0016239Biological processpositive regulation of macroautophagy
GO_0043123Biological processpositive regulation of canonical NF-kappaB signal transduction
GO_0043161Biological processproteasome-mediated ubiquitin-dependent protein catabolic process
GO_0009653Biological processanatomical structure morphogenesis
GO_0044790Biological processsuppression of viral release by host
GO_0036503Biological processERAD pathway
GO_0032897Biological processnegative regulation of viral transcription
GO_0005789Cellular componentendoplasmic reticulum membrane
GO_0097038Cellular componentperinuclear endoplasmic reticulum
GO_0005737Cellular componentcytoplasm
GO_0061630Molecular functionubiquitin protein ligase activity
GO_0061659Molecular functionubiquitin-like protein ligase activity
GO_0008270Molecular functionzinc ion binding
GO_0004842Molecular functionubiquitin-protein transferase activity
GO_0003713Molecular functiontranscription coactivator activity
GO_0005515Molecular functionprotein binding

IV. Literature review

[source]
Gene nameTRIM13
Protein nameTripartite motif containing 13
E3 ubiquitin-protein ligase TRIM13 (EC 2.3.2.27) (B-cell chronic lymphocytic leukemia tumor suppressor Leu5) (Leukemia-associated protein 5) (Putative tumor suppressor RFP2) (RING finger protein 77) (RING-type E3 ubiquitin transferase TRIM13) (Ret finger protein 2) (Tripartite motif-containing protein 13)
Alternative protein TRIM13
SynonymsRNF77
LEU5
RFP2
DescriptionFUNCTION: Endoplasmic reticulum (ER) membrane anchored E3 ligase involved in the retrotranslocation and turnover of membrane and secretory proteins from the ER through a set of processes named ER-associated degradation (ERAD). This process acts on misfolded proteins as well as in the regulated degradation of correctly folded proteins. Enhances ionizing radiation-induced p53/TP53 stability and apoptosis via ubiquitinating MDM2 and AKT1 and decreasing AKT1 kinase activity through MDM2 and AKT1 proteasomal degradation. Regulates ER stress-induced autophagy, and may act as a tumor suppressor . Also plays a role in innate immune response by stimulating NF-kappa-B activity in the TLR2 signaling pathway. Ubiquitinates TRAF6 via the 'Lys-29'-linked polyubiquitination chain resulting in NF-kappa-B activation . Participates as well in T-cell receptor-mediated NF-kappa-B activation . In the presence of TNF, modulates the IKK complex by regulating IKBKG/NEMO ubiquitination leading to the repression of NF-kappa-B . .

AccessionsO60858
ENST00000442421.5
ENST00000356017.8 [O60858-3]
X6RH27
ENST00000378183.8
ENST00000378182.4 [O60858-1]
L8E9D0
ENST00000457662.2 [O60858-1]
ENST00000420995.6 [O60858-1]
X6R9U5