TLK2 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0006325Biological processchromatin organization
GO_0018105Biological processpeptidyl-serine phosphorylation
GO_0032435Biological processnegative regulation of proteasomal ubiquitin-dependent protein catabolic process
GO_1902275Biological processregulation of chromatin organization
GO_0007059Biological processchromosome segregation
GO_0006974Biological processDNA damage response
GO_0051647Biological processnucleus localization
GO_0071480Biological processcellular response to gamma radiation
GO_0035556Biological processintracellular signal transduction
GO_0010507Biological processnegative regulation of autophagy
GO_0006468Biological processprotein phosphorylation
GO_0048471Cellular componentperinuclear region of cytoplasm
GO_0005654Cellular componentnucleoplasm
GO_0005882Cellular componentintermediate filament
GO_0005634Cellular componentnucleus
GO_0106310Molecular functionprotein serine kinase activity
GO_0004674Molecular functionprotein serine/threonine kinase activity
GO_0042802Molecular functionidentical protein binding
GO_0005524Molecular functionATP binding
GO_0005515Molecular functionprotein binding

IV. Literature review

[source]
Gene nameTLK2
Protein nameSerine/threonine-protein kinase tousled-like 2 (EC 2.7.11.1) (HsHPK) (PKU-alpha) (Tousled-like kinase 2)
Tousled like kinase 2
Synonyms
DescriptionFUNCTION: Serine/threonine-protein kinase involved in the process of chromatin assembly and probably also DNA replication, transcription, repair, and chromosome segregation . Phosphorylates the chromatin assembly factors ASF1A and ASF1B . Phosphorylation of ASF1A prevents its proteasome-mediated degradation, thereby enhancing chromatin assembly . Negative regulator of amino acid starvation-induced autophagy . .

AccessionsJ3KRK0
ENST00000684012.1
A0A804HJZ9
J3QS73
ENST00000579450.5
ENST00000684440.1
A0A804HK10
ENST00000580705.5
J3QQN4
J3QR10
ENST00000326270.13 [Q86UE8-1]
ENST00000682085.1 [Q86UE8-2]
ENST00000581041.5
A0A804HIB4
ENST00000583843.5
ENST00000582809.5
ENST00000684772.1
J3QS44
ENST00000583690.6
A0A804HJM7
ENST00000682827.1
ENST00000683536.1
ENST00000346027.10 [Q86UE8-2]
ENST00000343388.11 [Q86UE8-3]
ENST00000682203.1
ENST00000684553.1
Q86UE8
A0A804HJX3
ENST00000683104.1 [Q86UE8-3]
A0A804HKD4
J3QLK5
ENST00000682274.1
A0A804HKF1
ENST00000684213.1
ENST00000682075.1