Name | Number of supported studies | Average coverage | |
|---|---|---|---|
| endothelial cell | 19 studies | 29% ± 12% | |
| astrocyte | 10 studies | 32% ± 16% | |
| oligodendrocyte | 10 studies | 33% ± 13% | |
| microglial cell | 9 studies | 29% ± 10% | |
| oligodendrocyte precursor cell | 9 studies | 30% ± 14% | |
| adipocyte | 9 studies | 26% ± 8% | |
| fibroblast | 9 studies | 27% ± 10% | |
| macrophage | 8 studies | 31% ± 12% | |
| glutamatergic neuron | 7 studies | 40% ± 22% | |
| GABAergic neuron | 7 studies | 35% ± 18% | |
| epithelial cell | 6 studies | 36% ± 16% | |
| dendritic cell | 6 studies | 20% ± 7% | |
| B cell | 5 studies | 21% ± 5% | |
| myeloid cell | 5 studies | 23% ± 5% | |
| ciliated cell | 5 studies | 23% ± 9% | |
| endothelial cell of lymphatic vessel | 5 studies | 30% ± 10% | |
| monocyte | 5 studies | 22% ± 7% | |
| smooth muscle cell | 5 studies | 24% ± 6% | |
| type I pneumocyte | 5 studies | 26% ± 9% | |
| type II pneumocyte | 5 studies | 23% ± 8% | |
| interneuron | 5 studies | 39% ± 25% | |
| natural killer cell | 4 studies | 18% ± 1% | |
| CD4-positive, alpha-beta T cell | 4 studies | 17% ± 2% | |
| cardiac muscle cell | 4 studies | 23% ± 1% | |
| lymphocyte | 4 studies | 27% ± 9% | |
| retinal rod cell | 4 studies | 21% ± 3% | |
| club cell | 4 studies | 27% ± 10% | |
| pericyte | 4 studies | 30% ± 11% | |
| basal cell | 4 studies | 29% ± 19% | |
| neuron | 4 studies | 40% ± 16% | |
| naive thymus-derived CD4-positive, alpha-beta T cell | 3 studies | 17% ± 2% | |
| plasma cell | 3 studies | 31% ± 8% | |
| ON-bipolar cell | 3 studies | 19% ± 5% | |
| rod bipolar cell | 3 studies | 22% ± 5% | |
| hepatocyte | 3 studies | 37% ± 20% | |
| ependymal cell | 3 studies | 32% ± 13% | |
| T cell | 3 studies | 20% ± 4% | |
| alveolar macrophage | 3 studies | 33% ± 10% | |
| goblet cell | 3 studies | 36% ± 25% |
Tissue | GTEx Coverage | GTEx Average TPM | GTEx Number of samples | TCGA Coverage | TCGA Average TPM | TCGA Number of samples |
|---|---|---|---|---|---|---|
| breast | 100% | 1755.49 | 459 / 459 | 100% | 17.86 | 1118 / 1118 |
| esophagus | 100% | 1737.75 | 1445 / 1445 | 100% | 15.57 | 183 / 183 |
| lung | 100% | 1787.48 | 578 / 578 | 100% | 13.74 | 1155 / 1155 |
| brain | 100% | 1331.54 | 2639 / 2642 | 100% | 15.58 | 705 / 705 |
| prostate | 100% | 1617.83 | 245 / 245 | 100% | 11.46 | 501 / 502 |
| uterus | 100% | 1979.89 | 170 / 170 | 100% | 14.45 | 457 / 459 |
| thymus | 100% | 1604.75 | 653 / 653 | 99% | 12.85 | 601 / 605 |
| ovary | 100% | 1754.14 | 180 / 180 | 99% | 10.16 | 426 / 430 |
| bladder | 100% | 1766.48 | 21 / 21 | 99% | 13.02 | 499 / 504 |
| pancreas | 100% | 764.98 | 327 / 328 | 99% | 11.10 | 176 / 178 |
| stomach | 100% | 1206.89 | 359 / 359 | 98% | 10.89 | 281 / 286 |
| kidney | 100% | 1197.67 | 89 / 89 | 98% | 9.45 | 879 / 901 |
| intestine | 100% | 1827.34 | 966 / 966 | 97% | 10.36 | 513 / 527 |
| skin | 100% | 1954.89 | 1808 / 1809 | 97% | 12.49 | 457 / 472 |
| adrenal gland | 100% | 1438.28 | 258 / 258 | 94% | 8.58 | 217 / 230 |
| liver | 100% | 703.16 | 226 / 226 | 94% | 6.58 | 380 / 406 |
| adipose | 100% | 1797.40 | 1204 / 1204 | 0% | 0 | 0 / 0 |
| blood vessel | 100% | 1858.39 | 1335 / 1335 | 0% | 0 | 0 / 0 |
| lymph node | 0% | 0 | 0 / 0 | 100% | 11.88 | 29 / 29 |
| muscle | 100% | 2045.29 | 803 / 803 | 0% | 0 | 0 / 0 |
| spleen | 100% | 1655.41 | 241 / 241 | 0% | 0 | 0 / 0 |
| tonsil | 0% | 0 | 0 / 0 | 100% | 12.93 | 45 / 45 |
| ureter | 0% | 0 | 0 / 0 | 100% | 6.07 | 1 / 1 |
| heart | 98% | 1151.72 | 848 / 861 | 0% | 0 | 0 / 0 |
| peripheral blood | 97% | 1320.00 | 899 / 929 | 0% | 0 | 0 / 0 |
| eye | 0% | 0 | 0 / 0 | 91% | 7.25 | 73 / 80 |
| abdomen | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| bone marrow | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| diaphragm | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| gingiva | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nasal cavity | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nasopharynx | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nose | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| placenta | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| spinal column | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| GO_0006325 | Biological process | chromatin organization |
| GO_0018105 | Biological process | peptidyl-serine phosphorylation |
| GO_0032435 | Biological process | negative regulation of proteasomal ubiquitin-dependent protein catabolic process |
| GO_1902275 | Biological process | regulation of chromatin organization |
| GO_0007059 | Biological process | chromosome segregation |
| GO_0006974 | Biological process | DNA damage response |
| GO_0051647 | Biological process | nucleus localization |
| GO_0071480 | Biological process | cellular response to gamma radiation |
| GO_0035556 | Biological process | intracellular signal transduction |
| GO_0010507 | Biological process | negative regulation of autophagy |
| GO_0006468 | Biological process | protein phosphorylation |
| GO_0048471 | Cellular component | perinuclear region of cytoplasm |
| GO_0005654 | Cellular component | nucleoplasm |
| GO_0005882 | Cellular component | intermediate filament |
| GO_0005634 | Cellular component | nucleus |
| GO_0106310 | Molecular function | protein serine kinase activity |
| GO_0004674 | Molecular function | protein serine/threonine kinase activity |
| GO_0042802 | Molecular function | identical protein binding |
| GO_0005524 | Molecular function | ATP binding |
| GO_0005515 | Molecular function | protein binding |
| Gene name | TLK2 |
| Protein name | Serine/threonine-protein kinase tousled-like 2 (EC 2.7.11.1) (HsHPK) (PKU-alpha) (Tousled-like kinase 2) Tousled like kinase 2 |
| Synonyms | |
| Description | FUNCTION: Serine/threonine-protein kinase involved in the process of chromatin assembly and probably also DNA replication, transcription, repair, and chromosome segregation . Phosphorylates the chromatin assembly factors ASF1A and ASF1B . Phosphorylation of ASF1A prevents its proteasome-mediated degradation, thereby enhancing chromatin assembly . Negative regulator of amino acid starvation-induced autophagy . . |
| Accessions | J3KRK0 ENST00000684012.1 A0A804HJZ9 J3QS73 ENST00000579450.5 ENST00000684440.1 A0A804HK10 ENST00000580705.5 J3QQN4 J3QR10 ENST00000326270.13 [Q86UE8-1] ENST00000682085.1 [Q86UE8-2] ENST00000581041.5 A0A804HIB4 ENST00000583843.5 ENST00000582809.5 ENST00000684772.1 J3QS44 ENST00000583690.6 A0A804HJM7 ENST00000682827.1 ENST00000683536.1 ENST00000346027.10 [Q86UE8-2] ENST00000343388.11 [Q86UE8-3] ENST00000682203.1 ENST00000684553.1 Q86UE8 A0A804HJX3 ENST00000683104.1 [Q86UE8-3] A0A804HKD4 J3QLK5 ENST00000682274.1 A0A804HKF1 ENST00000684213.1 ENST00000682075.1 |