TIFA report

I. Expression across cell types

II. Expression across tissues

sc-RNAseq data

Insufficient scRNA-seq data for expression of TIFA at tissue level.

III. Associated gene sets

GO_0051260Biological processprotein homooligomerization
GO_0043123Biological processpositive regulation of canonical NF-kappaB signal transduction
GO_0002753Biological processcytoplasmic pattern recognition receptor signaling pathway
GO_0033209Biological processtumor necrosis factor-mediated signaling pathway
GO_0045087Biological processinnate immune response
GO_0005829Cellular componentcytosol
GO_0005737Cellular componentcytoplasm
GO_0005515Molecular functionprotein binding

IV. Literature review

[source]
Gene nameTIFA
Protein nameTRAF-interacting protein with FHA domain-containing protein A (Putative MAPK-activating protein PM14) (Putative NF-kappa-B-activating protein 20) (TRAF2-binding protein)
TIFA protein
SynonymsT2BP
DescriptionFUNCTION: Adapter molecule that plays a key role in the activation of pro-inflammatory NF-kappa-B signaling following detection of bacterial pathogen-associated molecular pattern metabolites (PAMPs) . Promotes activation of an innate immune response by inducing the oligomerization and polyubiquitination of TRAF6, which leads to the activation of TAK1 and IKK through a proteasome-independent mechanism . TIFA-dependent innate immune response is triggered by ADP-D-glycero-beta-D-manno-heptose (ADP-Heptose), a potent PAMP present in all Gram-negative and some Gram-positive bacteria: ADP-Heptose is recognized by ALPK1, which phosphorylates TIFA at Thr-9, leading to TIFA homooligomerization and subsequent activation of pro-inflammatory NF-kappa-B signaling . .

AccessionsENST00000500655.2
ENST00000361717.4
I6L962
Q96CG3
ENST00000610220.2