TGS1 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0022613Biological processribonucleoprotein complex biogenesis
GO_0000387Biological processspliceosomal snRNP assembly
GO_0036261Biological process7-methylguanosine cap hypermethylation
GO_0015030Cellular componentCajal body
GO_0005730Cellular componentnucleolus
GO_0005615Cellular componentextracellular space
GO_0005654Cellular componentnucleoplasm
GO_0005829Cellular componentcytosol
GO_0030532Cellular componentsmall nuclear ribonucleoprotein complex
GO_0005737Cellular componentcytoplasm
GO_0005634Cellular componentnucleus
GO_0008173Molecular functionRNA methyltransferase activity
GO_0005515Molecular functionprotein binding
GO_0071164Molecular functionRNA cap trimethylguanosine synthase activity

IV. Literature review

[source]
Gene nameTGS1
Protein nameTrimethylguanosine synthase 1
Trimethylguanosine synthase (EC 2.1.1.-) (CLL-associated antigen KW-2) (Cap-specific guanine-N2 methyltransferase) (Hepatocellular carcinoma-associated antigen 137) (Nuclear receptor coactivator 6-interacting protein) (PRIP-interacting protein with methyltransferase motif) (PIMT) (PIPMT)
SynonymsPIMT
NCOA6IP
HCA137
DescriptionFUNCTION: Catalyzes the 2 serial methylation steps for the conversion of the 7-monomethylguanosine (m(7)G) caps of snRNAs and snoRNAs to a 2,2,7-trimethylguanosine (m(2,2,7)G) cap structure. The enzyme is specific for guanine, and N7 methylation must precede N2 methylation. Hypermethylation of the m7G cap of U snRNAs leads to their concentration in nuclear foci, their colocalization with coilin and the formation of canonical Cajal bodies (CBs). Plays a role in transcriptional regulation. .

AccessionsENST00000260129.6
Q96RS0
E5RJW7
ENST00000523948.5