Name | Number of supported studies | Average coverage | |
---|---|---|---|
classical monocyte | 20 studies | 28% ± 9% | |
macrophage | 18 studies | 37% ± 17% | |
endothelial cell | 15 studies | 26% ± 11% | |
monocyte | 14 studies | 35% ± 17% | |
non-classical monocyte | 13 studies | 26% ± 10% | |
microglial cell | 12 studies | 44% ± 13% | |
dendritic cell | 11 studies | 40% ± 17% | |
conventional dendritic cell | 11 studies | 24% ± 7% | |
astrocyte | 11 studies | 34% ± 15% | |
oligodendrocyte precursor cell | 11 studies | 35% ± 16% | |
oligodendrocyte | 11 studies | 30% ± 10% | |
myeloid cell | 10 studies | 33% ± 10% | |
GABAergic neuron | 8 studies | 42% ± 18% | |
neutrophil | 7 studies | 26% ± 9% | |
mast cell | 7 studies | 28% ± 7% | |
mononuclear phagocyte | 6 studies | 24% ± 8% | |
glutamatergic neuron | 6 studies | 40% ± 21% | |
interneuron | 6 studies | 41% ± 23% | |
B cell | 6 studies | 20% ± 6% | |
epithelial cell | 6 studies | 37% ± 21% | |
fibroblast | 6 studies | 25% ± 7% | |
respiratory goblet cell | 5 studies | 34% ± 16% | |
basal cell | 5 studies | 31% ± 14% | |
club cell | 5 studies | 28% ± 11% | |
pericyte | 5 studies | 21% ± 6% | |
type II pneumocyte | 5 studies | 25% ± 7% | |
natural killer cell | 4 studies | 19% ± 3% | |
CD16-positive, CD56-dim natural killer cell, human | 4 studies | 18% ± 0% | |
neuron | 4 studies | 48% ± 19% | |
cardiac muscle cell | 4 studies | 18% ± 1% | |
ciliated cell | 4 studies | 23% ± 3% | |
lymphocyte | 4 studies | 22% ± 5% | |
brush cell | 4 studies | 31% ± 12% | |
endothelial cell of lymphatic vessel | 4 studies | 21% ± 1% | |
smooth muscle cell | 4 studies | 22% ± 2% | |
type I pneumocyte | 4 studies | 20% ± 5% | |
plasmacytoid dendritic cell | 4 studies | 21% ± 5% | |
adipocyte | 4 studies | 25% ± 3% | |
ionocyte | 3 studies | 24% ± 7% | |
hematopoietic precursor cell | 3 studies | 40% ± 21% | |
GABAergic interneuron | 3 studies | 30% ± 7% | |
squamous epithelial cell | 3 studies | 38% ± 25% | |
retina horizontal cell | 3 studies | 27% ± 8% | |
retinal rod cell | 3 studies | 20% ± 2% | |
connective tissue cell | 3 studies | 20% ± 4% | |
ependymal cell | 3 studies | 35% ± 18% | |
T cell | 3 studies | 19% ± 2% | |
alveolar macrophage | 3 studies | 42% ± 12% | |
mucus secreting cell | 3 studies | 20% ± 4% |
Tissue | GTEx Coverage | GTEx Average TPM | GTEx Number of samples | TCGA Coverage | TCGA Average TPM | TCGA Number of samples |
---|---|---|---|---|---|---|
esophagus | 100% | 2419.27 | 1444 / 1445 | 99% | 10.35 | 182 / 183 |
breast | 100% | 2291.60 | 459 / 459 | 97% | 8.29 | 1088 / 1118 |
lung | 100% | 3124.34 | 578 / 578 | 97% | 6.96 | 1124 / 1155 |
prostate | 100% | 2252.78 | 245 / 245 | 93% | 5.64 | 468 / 502 |
brain | 94% | 854.56 | 2481 / 2642 | 99% | 8.18 | 698 / 705 |
uterus | 100% | 3109.38 | 170 / 170 | 92% | 6.81 | 424 / 459 |
pancreas | 98% | 976.74 | 321 / 328 | 94% | 5.29 | 167 / 178 |
thymus | 100% | 2239.00 | 652 / 653 | 91% | 4.91 | 550 / 605 |
stomach | 100% | 1334.44 | 358 / 359 | 90% | 5.18 | 256 / 286 |
bladder | 100% | 1875.81 | 21 / 21 | 89% | 5.49 | 448 / 504 |
kidney | 100% | 1488.04 | 89 / 89 | 88% | 5.38 | 792 / 901 |
intestine | 100% | 2047.31 | 966 / 966 | 87% | 4.42 | 458 / 527 |
adrenal gland | 100% | 1423.17 | 258 / 258 | 83% | 3.65 | 192 / 230 |
ovary | 100% | 2195.59 | 180 / 180 | 75% | 2.92 | 322 / 430 |
skin | 100% | 3552.98 | 1809 / 1809 | 69% | 3.40 | 324 / 472 |
liver | 94% | 793.37 | 213 / 226 | 25% | 0.84 | 100 / 406 |
adipose | 100% | 2047.11 | 1204 / 1204 | 0% | 0 | 0 / 0 |
spleen | 100% | 3499.05 | 241 / 241 | 0% | 0 | 0 / 0 |
tonsil | 0% | 0 | 0 / 0 | 100% | 10.27 | 45 / 45 |
ureter | 0% | 0 | 0 / 0 | 100% | 2.04 | 1 / 1 |
blood vessel | 100% | 1879.15 | 1330 / 1335 | 0% | 0 | 0 / 0 |
peripheral blood | 99% | 4882.53 | 921 / 929 | 0% | 0 | 0 / 0 |
muscle | 98% | 1076.02 | 789 / 803 | 0% | 0 | 0 / 0 |
heart | 94% | 1104.75 | 807 / 861 | 0% | 0 | 0 / 0 |
lymph node | 0% | 0 | 0 / 0 | 72% | 3.82 | 21 / 29 |
eye | 0% | 0 | 0 / 0 | 39% | 1.39 | 31 / 80 |
abdomen | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
bone marrow | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
diaphragm | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
gingiva | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
nasal cavity | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
nasopharynx | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
nose | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
placenta | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
spinal column | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
GO_0014070 | Biological process | response to organic cyclic compound |
GO_0030099 | Biological process | myeloid cell differentiation |
GO_0006211 | Biological process | 5-methylcytosine catabolic process |
GO_0002521 | Biological process | leukocyte differentiation |
GO_0006493 | Biological process | protein O-linked glycosylation |
GO_0044029 | Biological process | positive regulation of gene expression via chromosomal CpG island demethylation |
GO_0045944 | Biological process | positive regulation of transcription by RNA polymerase II |
GO_0005694 | Cellular component | chromosome |
GO_0005654 | Cellular component | nucleoplasm |
GO_0005634 | Cellular component | nucleus |
GO_0003677 | Molecular function | DNA binding |
GO_0008198 | Molecular function | ferrous iron binding |
GO_0070579 | Molecular function | 5-methylcytosine dioxygenase activity |
GO_0005515 | Molecular function | protein binding |
GO_0008270 | Molecular function | zinc ion binding |
Gene name | TET2 |
Protein name | Methylcytosine dioxygenase TET (EC 1.14.11.80) Alternative protein TET2 Methylcytosine dioxygenase TET2 (EC 1.14.11.80) |
Synonyms | Nbla00191 KIAA1546 |
Description | FUNCTION: Dioxygenase that catalyzes the conversion of the modified genomic base 5-methylcytosine (5mC) into 5-hydroxymethylcytosine (5hmC) and plays a key role in active DNA demethylation. Has a preference for 5-hydroxymethylcytosine in CpG motifs. Also mediates subsequent conversion of 5hmC into 5-formylcytosine (5fC), and conversion of 5fC to 5-carboxylcytosine (5caC). Conversion of 5mC into 5hmC, 5fC and 5caC probably constitutes the first step in cytosine demethylation. Methylation at the C5 position of cytosine bases is an epigenetic modification of the mammalian genome which plays an important role in transcriptional regulation. In addition to its role in DNA demethylation, also involved in the recruitment of the O-GlcNAc transferase OGT to CpG-rich transcription start sites of active genes, thereby promoting histone H2B GlcNAcylation by OGT. . FUNCTION: Dioxygenase that catalyzes the conversion of the modified genomic base 5-methylcytosine (5mC) into 5-hydroxymethylcytosine (5hmC) and plays a key role in epigenetic chromatin reprogramming during embryonic development. . FUNCTION: Dioxygenase that catalyzes the conversion of the modified genomic base 5-methylcytosine (5mC) into 5-hydroxymethylcytosine (5hmC) and plays a key role in epigenetic chromatin reprogramming during embryonic development. . FUNCTION: Dioxygenase that catalyzes the conversion of the modified genomic base 5-methylcytosine (5mC) into 5-hydroxymethylcytosine (5hmC) and plays a key role in epigenetic chromatin reprogramming during embryonic development. . FUNCTION: Dioxygenase that catalyzes the conversion of the modified genomic base 5-methylcytosine (5mC) into 5-hydroxymethylcytosine (5hmC) and plays a key role in epigenetic chromatin reprogramming during embryonic development. . FUNCTION: Dioxygenase that catalyzes the conversion of the modified genomic base 5-methylcytosine (5mC) into 5-hydroxymethylcytosine (5hmC) and plays a key role in epigenetic chromatin reprogramming during embryonic development. . |
Accessions | A0A158SIU0 E7EPB1 D6RE87 E7EQS8 ENST00000413648.2 ENST00000540549.5 [Q6N021-1] A7E237 ENST00000514870.1 ENST00000380013.9 [Q6N021-1] ENST00000513237.5 ENST00000305737.6 [Q6N021-2] Q6N021 L8E8T1 ENST00000265149.9 [Q6N021-3] |