TET2 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0014070Biological processresponse to organic cyclic compound
GO_0030099Biological processmyeloid cell differentiation
GO_0006211Biological process5-methylcytosine catabolic process
GO_0002521Biological processleukocyte differentiation
GO_0006493Biological processprotein O-linked glycosylation
GO_0044029Biological processpositive regulation of gene expression via chromosomal CpG island demethylation
GO_0045944Biological processpositive regulation of transcription by RNA polymerase II
GO_0005694Cellular componentchromosome
GO_0005654Cellular componentnucleoplasm
GO_0005634Cellular componentnucleus
GO_0003677Molecular functionDNA binding
GO_0008198Molecular functionferrous iron binding
GO_0070579Molecular function5-methylcytosine dioxygenase activity
GO_0005515Molecular functionprotein binding
GO_0008270Molecular functionzinc ion binding

IV. Literature review

[source]
Gene nameTET2
Protein nameMethylcytosine dioxygenase TET (EC 1.14.11.80)
Alternative protein TET2
Methylcytosine dioxygenase TET2 (EC 1.14.11.80)
SynonymsNbla00191
KIAA1546
DescriptionFUNCTION: Dioxygenase that catalyzes the conversion of the modified genomic base 5-methylcytosine (5mC) into 5-hydroxymethylcytosine (5hmC) and plays a key role in active DNA demethylation. Has a preference for 5-hydroxymethylcytosine in CpG motifs. Also mediates subsequent conversion of 5hmC into 5-formylcytosine (5fC), and conversion of 5fC to 5-carboxylcytosine (5caC). Conversion of 5mC into 5hmC, 5fC and 5caC probably constitutes the first step in cytosine demethylation. Methylation at the C5 position of cytosine bases is an epigenetic modification of the mammalian genome which plays an important role in transcriptional regulation. In addition to its role in DNA demethylation, also involved in the recruitment of the O-GlcNAc transferase OGT to CpG-rich transcription start sites of active genes, thereby promoting histone H2B GlcNAcylation by OGT. .

FUNCTION: Dioxygenase that catalyzes the conversion of the modified genomic base 5-methylcytosine (5mC) into 5-hydroxymethylcytosine (5hmC) and plays a key role in epigenetic chromatin reprogramming during embryonic development. .

FUNCTION: Dioxygenase that catalyzes the conversion of the modified genomic base 5-methylcytosine (5mC) into 5-hydroxymethylcytosine (5hmC) and plays a key role in epigenetic chromatin reprogramming during embryonic development. .

FUNCTION: Dioxygenase that catalyzes the conversion of the modified genomic base 5-methylcytosine (5mC) into 5-hydroxymethylcytosine (5hmC) and plays a key role in epigenetic chromatin reprogramming during embryonic development. .

FUNCTION: Dioxygenase that catalyzes the conversion of the modified genomic base 5-methylcytosine (5mC) into 5-hydroxymethylcytosine (5hmC) and plays a key role in epigenetic chromatin reprogramming during embryonic development. .

FUNCTION: Dioxygenase that catalyzes the conversion of the modified genomic base 5-methylcytosine (5mC) into 5-hydroxymethylcytosine (5hmC) and plays a key role in epigenetic chromatin reprogramming during embryonic development. .

AccessionsA0A158SIU0
E7EPB1
D6RE87
E7EQS8
ENST00000413648.2
ENST00000540549.5 [Q6N021-1]
A7E237
ENST00000514870.1
ENST00000380013.9 [Q6N021-1]
ENST00000513237.5
ENST00000305737.6 [Q6N021-2]
Q6N021
L8E8T1
ENST00000265149.9 [Q6N021-3]