TERF1 | OmnibusX

I. Expression across cell types

Name	Number of supported studies	Average coverage
natural killer cell	17 studies	23% ± 5%	Explore
fibroblast	12 studies	22% ± 8%	Explore
smooth muscle cell	12 studies	28% ± 15%	Explore
endothelial cell	11 studies	24% ± 7%	Explore
CD16-positive, CD56-dim natural killer cell, human	9 studies	22% ± 7%	Explore
pericyte	8 studies	21% ± 3%	Explore
CD8-positive, alpha-beta T cell	7 studies	20% ± 5%	Explore
myofibroblast cell	7 studies	28% ± 9%	Explore
glutamatergic neuron	7 studies	39% ± 22%	Explore
astrocyte	7 studies	25% ± 9%	Explore
GABAergic neuron	7 studies	34% ± 17%	Explore
CD16-negative, CD56-bright natural killer cell, human	6 studies	21% ± 4%	Explore
oligodendrocyte	6 studies	26% ± 6%	Explore
B cell	5 studies	23% ± 4%	Explore
mature NK T cell	5 studies	23% ± 3%	Explore
connective tissue cell	5 studies	23% ± 4%	Explore
epithelial cell	5 studies	33% ± 12%	Explore
endothelial cell of lymphatic vessel	5 studies	20% ± 5%	Explore
oligodendrocyte precursor cell	5 studies	33% ± 8%	Explore
interneuron	5 studies	38% ± 22%	Explore
CD4-positive, alpha-beta T cell	4 studies	20% ± 2%	Explore
effector memory CD8-positive, alpha-beta T cell	4 studies	21% ± 3%	Explore
neuron	4 studies	33% ± 8%	Explore
precursor B cell	4 studies	32% ± 10%	Explore
retinal cone cell	4 studies	29% ± 10%	Explore
Mueller cell	4 studies	23% ± 6%	Explore
conventional dendritic cell	3 studies	25% ± 8%	Explore
abnormal cell	3 studies	20% ± 2%	Explore
mesothelial cell	3 studies	31% ± 11%	Explore
retinal bipolar neuron	3 studies	29% ± 8%	Explore
microglial cell	3 studies	17% ± 1%	Explore
amacrine cell	3 studies	35% ± 5%	Explore
retina horizontal cell	3 studies	23% ± 6%	Explore
ciliated cell	3 studies	23% ± 3%	Explore
lymphocyte	3 studies	21% ± 5%	Explore
rod bipolar cell	3 studies	23% ± 3%	Explore
CD8-positive, alpha-beta memory T cell	3 studies	20% ± 3%	Explore
naive B cell	3 studies	18% ± 1%	Explore
macrophage	3 studies	17% ± 2%	Explore
basal cell	3 studies	24% ± 5%	Explore
granule cell	3 studies	23% ± 5%	Explore
plasmacytoid dendritic cell	3 studies	26% ± 8%	Explore

II. Expression across tissues

Name	Number of supported studies	Average coverage
brain	9 studies	32% ± 17%	Explore
lung	5 studies	20% ± 2%	Explore
eye	5 studies	22% ± 5%	Explore
peripheral blood	3 studies	27% ± 7%	Explore
intestine	3 studies	23% ± 8%	Explore

Tissue	GTEx Coverage	GTEx Average TPM	GTEx Number of samples	TCGA Coverage	TCGA Average TPM	TCGA Number of samples
esophagus	100%	1436.27	1445 / 1445	100%	7.05	183 / 183
ovary	100%	2264.87	180 / 180	100%	7.56	429 / 430
brain	100%	1714.63	2640 / 2642	100%	8.56	703 / 705
breast	100%	1713.73	459 / 459	99%	8.35	1111 / 1118
lung	100%	1183.28	576 / 578	99%	6.15	1148 / 1155
prostate	100%	1733.71	245 / 245	98%	6.86	491 / 502
pancreas	99%	675.14	325 / 328	98%	4.50	174 / 178
bladder	100%	2204.52	21 / 21	97%	5.44	487 / 504
thymus	100%	1558.53	653 / 653	97%	5.49	584 / 605
stomach	100%	1408.53	359 / 359	95%	5.87	273 / 286
uterus	100%	1945.15	170 / 170	95%	6.05	438 / 459
intestine	100%	1413.81	966 / 966	95%	5.38	502 / 527
kidney	100%	1400.01	89 / 89	93%	5.51	838 / 901
adrenal gland	100%	1726.74	258 / 258	93%	6.03	213 / 230
skin	100%	1331.11	1808 / 1809	91%	5.86	428 / 472
liver	100%	688.15	225 / 226	87%	3.61	352 / 406
adipose	100%	1659.48	1204 / 1204	0%	0	0 / 0
blood vessel	100%	2163.82	1335 / 1335	0%	0	0 / 0
spleen	100%	1026.27	241 / 241	0%	0	0 / 0
tonsil	0%	0	0 / 0	100%	5.07	45 / 45
ureter	0%	0	0 / 0	100%	2.87	1 / 1
muscle	99%	742.67	793 / 803	0%	0	0 / 0
lymph node	0%	0	0 / 0	97%	4.11	28 / 29
heart	96%	954.11	823 / 861	0%	0	0 / 0
peripheral blood	85%	727.42	793 / 929	0%	0	0 / 0
eye	0%	0	0 / 0	69%	4.42	55 / 80
abdomen	0%	0	0 / 0	0%	0	0 / 0
bone marrow	0%	0	0 / 0	0%	0	0 / 0
diaphragm	0%	0	0 / 0	0%	0	0 / 0
gingiva	0%	0	0 / 0	0%	0	0 / 0
nasal cavity	0%	0	0 / 0	0%	0	0 / 0
nasopharynx	0%	0	0 / 0	0%	0	0 / 0
nose	0%	0	0 / 0	0%	0	0 / 0
placenta	0%	0	0 / 0	0%	0	0 / 0
spinal column	0%	0	0 / 0	0%	0	0 / 0

III. Associated gene sets

GO_0090656	Biological process	t-circle formation
GO_1904914	Biological process	negative regulation of establishment of protein-containing complex localization to telomere
GO_0051974	Biological process	negative regulation of telomerase activity
GO_1905778	Biological process	negative regulation of exonuclease activity
GO_0051301	Biological process	cell division
GO_1904792	Biological process	positive regulation of shelterin complex assembly
GO_0045141	Biological process	meiotic telomere clustering
GO_1905839	Biological process	negative regulation of telomeric D-loop disassembly
GO_1904357	Biological process	negative regulation of telomere maintenance via telomere lengthening
GO_1904850	Biological process	negative regulation of establishment of protein localization to telomere
GO_1904911	Biological process	negative regulation of establishment of RNA localization to telomere
GO_0032211	Biological process	negative regulation of telomere maintenance via telomerase
GO_0016233	Biological process	telomere capping
GO_0008156	Biological process	negative regulation of DNA replication
GO_0032206	Biological process	positive regulation of telomere maintenance
GO_0000723	Biological process	telomere maintenance
GO_0061820	Biological process	telomeric D-loop disassembly
GO_0032214	Biological process	negative regulation of telomere maintenance via semi-conservative replication
GO_0007004	Biological process	telomere maintenance via telomerase
GO_0005730	Cellular component	nucleolus
GO_0000783	Cellular component	nuclear telomere cap complex
GO_0005654	Cellular component	nucleoplasm
GO_0001650	Cellular component	fibrillar center
GO_0016604	Cellular component	nuclear body
GO_0005737	Cellular component	cytoplasm
GO_0000781	Cellular component	chromosome, telomeric region
GO_0070187	Cellular component	shelterin complex
GO_0005819	Cellular component	spindle
GO_0005634	Cellular component	nucleus
GO_0003677	Molecular function	DNA binding
GO_0042803	Molecular function	protein homodimerization activity
GO_0008301	Molecular function	DNA binding, bending
GO_0042162	Molecular function	telomeric DNA binding
GO_0042802	Molecular function	identical protein binding
GO_0003691	Molecular function	double-stranded telomeric DNA binding
GO_0071532	Molecular function	ankyrin repeat binding
GO_0003720	Molecular function	telomerase activity
GO_0008017	Molecular function	microtubule binding
GO_0098505	Molecular function	G-rich strand telomeric DNA binding
GO_0005515	Molecular function	protein binding

IV. Literature review

[source]

Gene name	TERF1
Protein name	Telomeric repeat-binding factor 1 (NIMA-interacting protein 2) (TTAGGG repeat-binding factor 1) (Telomeric protein Pin2/TRF1) Telomeric repeat-binding factor Telomeric repeat binding factor 1
Synonyms	TRF TRBF1 TRF1 PIN2
Description	FUNCTION: Binds the telomeric double-stranded 5'-TTAGGG-3' repeat and negatively regulates telomere length. Involved in the regulation of the mitotic spindle. Component of the shelterin complex (telosome) that is involved in the regulation of telomere length and protection. Shelterin associates with arrays of double-stranded 5'-TTAGGG-3' repeats added by telomerase and protects chromosome ends; without its protective activity, telomeres are no longer hidden from the DNA damage surveillance and chromosome ends are inappropriately processed by DNA repair pathways. . FUNCTION: Binds the telomeric double-stranded 5'-TTAGGG-3' repeat. . FUNCTION: Binds the telomeric double-stranded 5'-TTAGGG-3' repeat. . FUNCTION: Binds the telomeric double-stranded 5'-TTAGGG-3' repeat. . FUNCTION: Binds the telomeric double-stranded 5'-TTAGGG-3' repeat. .
Accessions	ENST00000276603.10 [P54274-1] A0A7I2V5T5 ENST00000517390.2 P54274 ENST00000679115.1 A0A7I2V3N9 A0A7I2V5E0 A0A7I2YQE7 ENST00000676483.1 ENST00000276602.10 [P54274-2] E7EWM7 A0A7I2V5I6 ENST00000678860.1 ENST00000678518.1 ENST00000678997.1 E5RFJ5 ENST00000518874.6

TERF1 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

IV. Literature review