TCF7L1 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0006325Biological processchromatin organization
GO_0030111Biological processregulation of Wnt signaling pathway
GO_0006355Biological processregulation of DNA-templated transcription
GO_0060070Biological processcanonical Wnt signaling pathway
GO_0006357Biological processregulation of transcription by RNA polymerase II
GO_1990907Cellular componentbeta-catenin-TCF complex
GO_0005654Cellular componentnucleoplasm
GO_0005829Cellular componentcytosol
GO_0000785Cellular componentchromatin
GO_0005634Cellular componentnucleus
GO_0003677Molecular functionDNA binding
GO_1990837Molecular functionsequence-specific double-stranded DNA binding
GO_0000978Molecular functionRNA polymerase II cis-regulatory region sequence-specific DNA binding
GO_0003700Molecular functionDNA-binding transcription factor activity
GO_0005515Molecular functionprotein binding
GO_0000981Molecular functionDNA-binding transcription factor activity, RNA polymerase II-specific

IV. Literature review

[source]
Gene nameTCF7L1
Protein nameTranscription factor 7 like 1
Uncharacterized protein TCF7L1
Transcription factor 7-like 1 (HMG box transcription factor 3) (TCF-3)
SynonymsTCF3
DescriptionFUNCTION: Participates in the Wnt signaling pathway. Binds to DNA and acts as a repressor in the absence of CTNNB1, and as an activator in its presence. Necessary for the terminal differentiation of epidermal cells, the formation of keratohyalin granules and the development of the barrier function of the epidermis (By similarity). Down-regulates NQO1, leading to increased mitomycin c resistance. .

AccessionsC9JPE3
Q9HCS4
ENST00000709854.1
Q53T87
ENST00000282111.4
ENST00000442813.1