Name | Number of supported studies  | Average coverage | |
|---|---|---|---|
| pericyte | 9 studies | 42% ± 13% | |
| fibroblast | 6 studies | 20% ± 5% | |
| cardiac muscle cell | 5 studies | 31% ± 4% | |
| myofibroblast cell | 4 studies | 34% ± 17% | |
| smooth muscle cell | 3 studies | 31% ± 7% |
Insufficient scRNA-seq data for expression of TBX5 at tissue level.
Tissue | GTEx Coverage | GTEx Average TPM | GTEx Number of samples | TCGA Coverage | TCGA Average TPM | TCGA Number of samples |
|---|---|---|---|---|---|---|
| lung | 100% | 3415.34 | 578 / 578 | 83% | 5.02 | 959 / 1155 |
| breast | 94% | 748.81 | 433 / 459 | 81% | 2.81 | 907 / 1118 |
| esophagus | 77% | 1251.82 | 1119 / 1445 | 61% | 2.44 | 111 / 183 |
| bladder | 90% | 838.52 | 19 / 21 | 28% | 1.11 | 140 / 504 |
| prostate | 60% | 556.35 | 146 / 245 | 50% | 1.76 | 249 / 502 |
| heart | 96% | 6500.93 | 828 / 861 | 0% | 0 | 0 / 0 |
| thymus | 38% | 230.64 | 248 / 653 | 8% | 0.23 | 48 / 605 |
| skin | 22% | 74.63 | 389 / 1809 | 15% | 0.68 | 73 / 472 |
| brain | 1% | 2.41 | 20 / 2642 | 32% | 2.57 | 229 / 705 |
| adipose | 32% | 161.88 | 386 / 1204 | 0% | 0 | 0 / 0 |
| blood vessel | 16% | 131.61 | 208 / 1335 | 0% | 0 | 0 / 0 |
| uterus | 1% | 1.48 | 1 / 170 | 12% | 0.75 | 54 / 459 |
| adrenal gland | 0% | 0 | 0 / 258 | 8% | 0.37 | 19 / 230 |
| intestine | 0% | 0.68 | 2 / 966 | 8% | 0.19 | 42 / 527 |
| lymph node | 0% | 0 | 0 / 0 | 7% | 0.12 | 2 / 29 |
| stomach | 1% | 2.83 | 2 / 359 | 6% | 0.23 | 17 / 286 |
| kidney | 0% | 0 | 0 / 89 | 6% | 0.44 | 57 / 901 |
| ovary | 1% | 2.19 | 1 / 180 | 4% | 0.08 | 17 / 430 |
| pancreas | 0% | 0 | 0 / 328 | 3% | 0.12 | 5 / 178 |
| tonsil | 0% | 0 | 0 / 0 | 2% | 0.06 | 1 / 45 |
| eye | 0% | 0 | 0 / 0 | 1% | 0.01 | 1 / 80 |
| liver | 0% | 0 | 0 / 226 | 1% | 0.04 | 4 / 406 |
| abdomen | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| bone marrow | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| diaphragm | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| gingiva | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| muscle | 0% | 0 | 0 / 803 | 0% | 0 | 0 / 0 |
| nasal cavity | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nasopharynx | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nose | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| peripheral blood | 0% | 0 | 0 / 929 | 0% | 0 | 0 / 0 |
| placenta | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| spinal column | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| spleen | 0% | 0 | 0 / 241 | 0% | 0 | 0 / 0 |
| ureter | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 1 |
| GO_0003218 | Biological process | cardiac left ventricle formation |
| GO_0006366 | Biological process | transcription by RNA polymerase II |
| GO_0060929 | Biological process | atrioventricular node cell fate commitment |
| GO_0008285 | Biological process | negative regulation of cell population proliferation |
| GO_1903781 | Biological process | positive regulation of cardiac conduction |
| GO_0030324 | Biological process | lung development |
| GO_0001708 | Biological process | cell fate specification |
| GO_0002009 | Biological process | morphogenesis of an epithelium |
| GO_0003167 | Biological process | atrioventricular bundle cell differentiation |
| GO_0060039 | Biological process | pericardium development |
| GO_0007507 | Biological process | heart development |
| GO_0035136 | Biological process | forelimb morphogenesis |
| GO_0060045 | Biological process | positive regulation of cardiac muscle cell proliferation |
| GO_0060928 | Biological process | atrioventricular node cell development |
| GO_0006357 | Biological process | regulation of transcription by RNA polymerase II |
| GO_0072513 | Biological process | positive regulation of secondary heart field cardioblast proliferation |
| GO_0060044 | Biological process | negative regulation of cardiac muscle cell proliferation |
| GO_0003181 | Biological process | atrioventricular valve morphogenesis |
| GO_0060413 | Biological process | atrial septum morphogenesis |
| GO_0051891 | Biological process | positive regulation of cardioblast differentiation |
| GO_0003281 | Biological process | ventricular septum development |
| GO_0086019 | Biological process | cell-cell signaling involved in cardiac conduction |
| GO_1901846 | Biological process | positive regulation of cell communication by electrical coupling involved in cardiac conduction |
| GO_0035115 | Biological process | embryonic forelimb morphogenesis |
| GO_0007267 | Biological process | cell-cell signaling |
| GO_1903598 | Biological process | positive regulation of gap junction assembly |
| GO_0060038 | Biological process | cardiac muscle cell proliferation |
| GO_0010719 | Biological process | negative regulation of epithelial to mesenchymal transition |
| GO_0045893 | Biological process | positive regulation of DNA-templated transcription |
| GO_0007389 | Biological process | pattern specification process |
| GO_0030326 | Biological process | embryonic limb morphogenesis |
| GO_0003197 | Biological process | endocardial cushion development |
| GO_0060371 | Biological process | regulation of atrial cardiac muscle cell membrane depolarization |
| GO_0003163 | Biological process | sinoatrial node development |
| GO_0030336 | Biological process | negative regulation of cell migration |
| GO_0060980 | Biological process | cell migration involved in coronary vasculogenesis |
| GO_0003166 | Biological process | bundle of His development |
| GO_0086054 | Biological process | bundle of His cell to Purkinje myocyte communication by electrical coupling |
| GO_0045944 | Biological process | positive regulation of transcription by RNA polymerase II |
| GO_0032993 | Cellular component | protein-DNA complex |
| GO_0032991 | Cellular component | protein-containing complex |
| GO_0005654 | Cellular component | nucleoplasm |
| GO_0005737 | Cellular component | cytoplasm |
| GO_0000785 | Cellular component | chromatin |
| GO_0005667 | Cellular component | transcription regulator complex |
| GO_0005634 | Cellular component | nucleus |
| GO_0003677 | Molecular function | DNA binding |
| GO_0000978 | Molecular function | RNA polymerase II cis-regulatory region sequence-specific DNA binding |
| GO_0001228 | Molecular function | DNA-binding transcription activator activity, RNA polymerase II-specific |
| GO_0000981 | Molecular function | DNA-binding transcription factor activity, RNA polymerase II-specific |
| GO_0043565 | Molecular function | sequence-specific DNA binding |
| GO_0061629 | Molecular function | RNA polymerase II-specific DNA-binding transcription factor binding |
| GO_0003700 | Molecular function | DNA-binding transcription factor activity |
| GO_0005515 | Molecular function | protein binding |
| Gene name | TBX5 |
| Protein name | T-box transcription factor TBX5 (T-box protein 5) |
| Synonyms | |
| Description | FUNCTION: DNA-binding protein that regulates the transcription of several genes and is involved in heart development and limb pattern formation . Binds to the core DNA motif of NPPA promoter . . |
| Accessions | ENST00000405440.7 [Q99593-1] ENST00000310346.8 [Q99593-1] Q99593 ENST00000349716.9 [Q99593-3] ENST00000526441.1 [Q99593-2] |
