TASOR report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0060809Biological processmesodermal to mesenchymal transition involved in gastrulation
GO_0097355Biological processprotein localization to heterochromatin
GO_0045814Biological processnegative regulation of gene expression, epigenetic
GO_0090309Biological processpositive regulation of DNA methylation-dependent heterochromatin formation
GO_0045869Biological processnegative regulation of single stranded viral RNA replication via double stranded DNA intermediate
GO_0008595Biological processanterior/posterior axis specification, embryo
GO_0000792Cellular componentheterochromatin
GO_0005654Cellular componentnucleoplasm
GO_0005515Molecular functionprotein binding
GO_0003682Molecular functionchromatin binding
GO_0003723Molecular functionRNA binding

IV. Literature review

[source]
Gene nameTASOR
Protein nameProtein TASOR (CTCL tumor antigen se89-1) (Retinoblastoma-associated protein RAP140) (Transgene activation suppressor protein)
Transcription activation suppressor
SynonymsKIAA1105
C3orf63
FAM208A
DescriptionFUNCTION: Component of the HUSH complex, a multiprotein complex that mediates epigenetic repression . The HUSH complex is recruited to genomic loci rich in H3K9me3 and is required to maintain transcriptional silencing by promoting recruitment of SETDB1, a histone methyltransferase that mediates further deposition of H3K9me3, as well as MORC2 . Also represses L1 retrotransposons in collaboration with MORC2 and, probably, SETDB1, the silencing is dependent of repressive epigenetic modifications, such as H3K9me3 mark. Silencing events often occur within introns of transcriptionally active genes, and lead to the down-regulation of host gene expression . The HUSH complex is also involved in the silencing of unintegrated retroviral DNA by being recruited by ZNF638: some part of the retroviral DNA formed immediately after infection remains unintegrated in the host genome and is transcriptionally repressed . Plays a crucial role in early embryonic development (By similarity). Involved in the organization of spindle poles and spindle apparatus assembly during zygotic division (By similarity). Plays an important role in maintaining epiblast fitness or potency (By similarity). .

AccessionsENST00000614531.1
Q9UK61
ENST00000493960.6 [Q9UK61-3]
ENST00000355628.9 [Q9UK61-4]
A0A087X0F1
ENST00000683822.1 [Q9UK61-1]
ENST00000431842.6 [Q9UK61-2]