SYVN1 report

I. Expression across cell types

II. Expression across tissues

sc-RNAseq data

Insufficient scRNA-seq data for expression of SYVN1 at tissue level.

III. Associated gene sets

GO_0016567Biological processprotein ubiquitination
GO_0030970Biological processretrograde protein transport, ER to cytosol
GO_1902236Biological processnegative regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway
GO_0006511Biological processubiquitin-dependent protein catabolic process
GO_0070936Biological processprotein K48-linked ubiquitination
GO_0050821Biological processprotein stabilization
GO_0002327Biological processimmature B cell differentiation
GO_0036503Biological processERAD pathway
GO_0043161Biological processproteasome-mediated ubiquitin-dependent protein catabolic process
GO_0000839Cellular componentHrd1p ubiquitin ligase ERAD-L complex
GO_0012505Cellular componentendomembrane system
GO_0005789Cellular componentendoplasmic reticulum membrane
GO_0016020Cellular componentmembrane
GO_0005790Cellular componentsmooth endoplasmic reticulum
GO_0005654Cellular componentnucleoplasm
GO_0044322Cellular componentendoplasmic reticulum quality control compartment
GO_0005783Cellular componentendoplasmic reticulum
GO_0000836Cellular componentHrd1p ubiquitin ligase complex
GO_0005737Cellular componentcytoplasm
GO_0036513Cellular componentDerlin-1 retrotranslocation complex
GO_0061630Molecular functionubiquitin protein ligase activity
GO_0051082Molecular functionunfolded protein binding
GO_0051087Molecular functionprotein-folding chaperone binding
GO_0046872Molecular functionmetal ion binding
GO_0051117Molecular functionATPase binding
GO_0005515Molecular functionprotein binding
GO_1990381Molecular functionubiquitin-specific protease binding

IV. Literature review

[source]
Gene nameSYVN1
Protein nameE3 ubiquitin-protein ligase synoviolin (EC 2.3.2.27) (RING-type E3 ubiquitin transferase synoviolin) (Synovial apoptosis inhibitor 1)
RING-type E3 ubiquitin transferase (EC 2.3.2.27)
SynonymsHRD1
KIAA1810
DescriptionFUNCTION: E3 ubiquitin-protein ligase which accepts ubiquitin specifically from endoplasmic reticulum-associated UBC7 E2 ligase and transfers it to substrates, promoting their degradation . Component of the endoplasmic reticulum quality control (ERQC) system also called ER-associated degradation (ERAD) involved in ubiquitin-dependent degradation of misfolded endoplasmic reticulum proteins . Also promotes the degradation of normal but naturally short-lived proteins such as SGK. Protects cells from ER stress-induced apoptosis. Protects neurons from apoptosis induced by polyglutamine-expanded huntingtin (HTT) or unfolded GPR37 by promoting their degradation . Sequesters p53/TP53 in the cytoplasm and promotes its degradation, thereby negatively regulating its biological function in transcription, cell cycle regulation and apoptosis . Mediates the ubiquitination and subsequent degradation of cytoplasmic NFE2L1 (By similarity). During the early stage of B cell development, required for degradation of the pre-B cell receptor (pre-BCR) complex, hence supporting further differentiation into mature B cells (By similarity). .

AccessionsENST00000528487.1
ENST00000307289.10 [Q86TM6-2]
E9PN88
ENST00000531018.5
E9PMA1
E9PK19
H0YCR6
ENST00000526060.5 [Q86TM6-3]
ENST00000294256.12 [Q86TM6-3]
Q86TM6
ENST00000532771.5
ENST00000377190.8 [Q86TM6-1]
ENST00000527142.5