SYT1 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0033603Biological processpositive regulation of dopamine secretion
GO_0048791Biological processcalcium ion-regulated exocytosis of neurotransmitter
GO_0099502Biological processcalcium-dependent activation of synaptic vesicle fusion
GO_0007269Biological processneurotransmitter secretion
GO_0098746Biological processfast, calcium ion-dependent exocytosis of neurotransmitter
GO_0048488Biological processsynaptic vesicle endocytosis
GO_0017157Biological processregulation of exocytosis
GO_0071911Biological processsynchronous neurotransmitter secretion
GO_1903861Biological processpositive regulation of dendrite extension
GO_0051966Biological processregulation of synaptic transmission, glutamatergic
GO_1903305Biological processregulation of regulated secretory pathway
GO_0071277Biological processcellular response to calcium ion
GO_1903235Biological processpositive regulation of calcium ion-dependent exocytosis of neurotransmitter
GO_0030154Biological processcell differentiation
GO_0007268Biological processchemical synaptic transmission
GO_0048278Biological processvesicle docking
GO_0051291Biological processprotein heterooligomerization
GO_0050806Biological processpositive regulation of synaptic transmission
GO_0061669Biological processspontaneous neurotransmitter secretion
GO_0005513Biological processdetection of calcium ion
GO_0070382Cellular componentexocytic vesicle
GO_0098978Cellular componentglutamatergic synapse
GO_0060201Cellular componentclathrin-sculpted acetylcholine transport vesicle membrane
GO_0060203Cellular componentclathrin-sculpted glutamate transport vesicle membrane
GO_0061202Cellular componentclathrin-sculpted gamma-aminobutyric acid transport vesicle membrane
GO_0005886Cellular componentplasma membrane
GO_0030672Cellular componentsynaptic vesicle membrane
GO_0042584Cellular componentchromaffin granule membrane
GO_0030669Cellular componentclathrin-coated endocytic vesicle membrane
GO_0005794Cellular componentGolgi apparatus
GO_0098686Cellular componenthippocampal mossy fiber to CA3 synapse
GO_0043005Cellular componentneuron projection
GO_0042734Cellular componentpresynaptic membrane
GO_0008021Cellular componentsynaptic vesicle
GO_0031045Cellular componentdense core granule
GO_0070083Cellular componentclathrin-sculpted monoamine transport vesicle membrane
GO_0005737Cellular componentcytoplasm
GO_0060076Cellular componentexcitatory synapse
GO_0030424Cellular componentaxon
GO_0044306Cellular componentneuron projection terminus
GO_0061891Molecular functioncalcium ion sensor activity
GO_0005544Molecular functioncalcium-dependent phospholipid binding
GO_0005546Molecular functionphosphatidylinositol-4,5-bisphosphate binding
GO_0001786Molecular functionphosphatidylserine binding
GO_0042802Molecular functionidentical protein binding
GO_0017075Molecular functionsyntaxin-1 binding
GO_0050750Molecular functionlow-density lipoprotein particle receptor binding
GO_0048306Molecular functioncalcium-dependent protein binding
GO_0000149Molecular functionSNARE binding
GO_0030276Molecular functionclathrin binding
GO_0046982Molecular functionprotein heterodimerization activity
GO_0030348Molecular functionsyntaxin-3 binding
GO_0005516Molecular functioncalmodulin binding
GO_0005509Molecular functioncalcium ion binding
GO_0005515Molecular functionprotein binding

IV. Literature review

[source]
Gene nameSYT1
Protein nameSynaptotagmin 1
Synaptotagmin
Synaptotagmin-1 (Synaptotagmin I) (SytI) (p65)
SynonymsSYT
hCG_2016754
SVP65
DescriptionFUNCTION: Calcium sensor that participates in triggering neurotransmitter release at the synapse (By similarity). May have a regulatory role in the membrane interactions during trafficking of synaptic vesicles at the active zone of the synapse (By similarity). It binds acidic phospholipids with a specificity that requires the presence of both an acidic head group and a diacyl backbone. A Ca(2+)-dependent interaction between synaptotagmin and putative receptors for activated protein kinase C has also been reported. It can bind to at least three additional proteins in a Ca(2+)-independent manner; these are neurexins, syntaxin and AP2. Plays a role in dendrite formation by melanocytes . .

FUNCTION: May have a regulatory role in the membrane interactions during trafficking of synaptic vesicles at the active zone of the synapse. It binds acidic phospholipids with a specificity that requires the presence of both an acidic head group and a diacyl backbone. .

FUNCTION: May have a regulatory role in the membrane interactions during trafficking of synaptic vesicles at the active zone of the synapse. It binds acidic phospholipids with a specificity that requires the presence of both an acidic head group and a diacyl backbone. .

FUNCTION: May have a regulatory role in the membrane interactions during trafficking of synaptic vesicles at the active zone of the synapse. It binds acidic phospholipids with a specificity that requires the presence of both an acidic head group and a diacyl backbone. .

FUNCTION: May have a regulatory role in the membrane interactions during trafficking of synaptic vesicles at the active zone of the synapse. It binds acidic phospholipids with a specificity that requires the presence of both an acidic head group and a diacyl backbone. .

FUNCTION: May have a regulatory role in the membrane interactions during trafficking of synaptic vesicles at the active zone of the synapse. It binds acidic phospholipids with a specificity that requires the presence of both an acidic head group and a diacyl backbone. .

FUNCTION: May have a regulatory role in the membrane interactions during trafficking of synaptic vesicles at the active zone of the synapse. It binds acidic phospholipids with a specificity that requires the presence of both an acidic head group and a diacyl backbone. .

FUNCTION: May have a regulatory role in the membrane interactions during trafficking of synaptic vesicles at the active zone of the synapse. It binds acidic phospholipids with a specificity that requires the presence of both an acidic head group and a diacyl backbone. .

FUNCTION: May have a regulatory role in the membrane interactions during trafficking of synaptic vesicles at the active zone of the synapse. It binds acidic phospholipids with a specificity that requires the presence of both an acidic head group and a diacyl backbone. .

AccessionsF8W1U9
ENST00000549671.5
ENST00000704719.1
ENST00000552744.5
A0A994J776
ENST00000457153.6
ENST00000261205.9
ENST00000704696.1
C9JX50
J3KQA0
ENST00000547046.5
ENST00000551304.5
ENST00000704698.1
ENST00000446242.3
A0A994J5A7
ENST00000704718.1
A0A994J4V4
P21579
ENST00000704711.1
ENST00000704707.1
ENST00000704700.1
ENST00000704710.1
ENST00000704703.1
A0A994J4M1
ENST00000704699.1
ENST00000704716.1
ENST00000704708.1
ENST00000704715.1
ENST00000552074.5
ENST00000704705.1
F8VYH8
ENST00000704709.1
A0A994J4M5
ENST00000393240.7
A0A994J7L5
A0A994J4V0
F8VZY3
ENST00000704717.1
ENST00000704706.1
ENST00000704704.1
ENST00000704714.1
F8VXH0
ENST00000552624.5
ENST00000704697.1
ENST00000704701.1
A0A994J784
ENST00000704702.1