SPPL3 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0006465Biological processsignal peptide processing
GO_0006509Biological processmembrane protein ectodomain proteolysis
GO_0033619Biological processmembrane protein proteolysis
GO_0032092Biological processpositive regulation of protein binding
GO_0070886Biological processpositive regulation of calcineurin-NFAT signaling cascade
GO_0050852Biological processT cell receptor signaling pathway
GO_0007204Biological processpositive regulation of cytosolic calcium ion concentration
GO_0035307Biological processpositive regulation of protein dephosphorylation
GO_0005886Cellular componentplasma membrane
GO_0016020Cellular componentmembrane
GO_0098554Cellular componentcytoplasmic side of endoplasmic reticulum membrane
GO_0005794Cellular componentGolgi apparatus
GO_0033116Cellular componentendoplasmic reticulum-Golgi intermediate compartment membrane
GO_0098553Cellular componentlumenal side of endoplasmic reticulum membrane
GO_0043231Cellular componentintracellular membrane-bounded organelle
GO_0030660Cellular componentGolgi-associated vesicle membrane
GO_0005791Cellular componentrough endoplasmic reticulum
GO_0042803Molecular functionprotein homodimerization activity
GO_0042500Molecular functionaspartic endopeptidase activity, intramembrane cleaving
GO_0005515Molecular functionprotein binding

IV. Literature review

[source]
Gene nameSPPL3
Protein nameSignal peptide peptidase-like 3 (SPP-like 3) (EC 3.4.23.-) (Intramembrane protease 2) (IMP-2) (Presenilin homologous protein 1) (PSH1) (Presenilin-like protein 4)
Signal peptide peptidase like 3
Alternative protein SPPL3
SynonymsPSL4
IMP2
DescriptionFUNCTION: Intramembrane-cleaving aspartic protease (I-CLiP) that cleaves type II membrane protein substrates in or close to their luminal transmembrane domain boundaries . Acts like a sheddase by mediating the proteolytic release and secretion of active site-containing ectodomains of glycan-modifiying glycosidase and glycosyltransferase enzymes such as MGAT5, B4GAT1 and B4GALT1 . Catalyzes the intramembrane cleavage of the envelope glycoprotein gp130 and/or the leader peptide gp18LP of the simian foamy virus independent of prior ectodomain shedding by furin or furin-like proprotein convertase (PC)-mediated cleavage proteolysis . May also have the ability to serve as a shedding protease for subsequent intramembrane proteolysis by SPPL2A and SPPL2B of the envelope glycoprotein gp130 . Plays a role in the regulation of cellular glycosylation processes . Required to link T-cell antigen receptor (TCR) and calcineurin-NFAT signaling cascades in lymphocytes by promoting the association of STIM1 and ORAI1 during store-operated calcium entry (SOCE) in a protease-independent manner . .

AccessionsENST00000353487.7 [Q8TCT6-2]
F5H4Y6
ENST00000543181.5
F5H6I1
F5H2A2
F5H7J2
ENST00000543854.5
Q8TCT6
ENST00000543608.5
ENST00000540091.1
L8EBD6
ENST00000536996.5
F5H4L1