Name | Number of supported studies | Average coverage | |
|---|---|---|---|
| endothelial cell | 26 studies | 31% ± 14% | |
| astrocyte | 16 studies | 35% ± 15% | |
| macrophage | 14 studies | 36% ± 18% | |
| oligodendrocyte precursor cell | 14 studies | 40% ± 16% | |
| oligodendrocyte | 14 studies | 44% ± 15% | |
| glutamatergic neuron | 12 studies | 44% ± 24% | |
| microglial cell | 12 studies | 43% ± 11% | |
| fibroblast | 12 studies | 25% ± 10% | |
| GABAergic neuron | 11 studies | 45% ± 22% | |
| pericyte | 10 studies | 29% ± 14% | |
| epithelial cell | 10 studies | 34% ± 18% | |
| adipocyte | 8 studies | 26% ± 7% | |
| type I pneumocyte | 8 studies | 28% ± 11% | |
| neuron | 7 studies | 45% ± 19% | |
| myeloid cell | 7 studies | 32% ± 11% | |
| basal cell | 7 studies | 39% ± 19% | |
| dendritic cell | 7 studies | 40% ± 13% | |
| interneuron | 6 studies | 55% ± 20% | |
| B cell | 6 studies | 24% ± 8% | |
| ciliated cell | 6 studies | 26% ± 8% | |
| endothelial cell of lymphatic vessel | 6 studies | 38% ± 14% | |
| type II pneumocyte | 6 studies | 28% ± 9% | |
| smooth muscle cell | 6 studies | 25% ± 5% | |
| amacrine cell | 5 studies | 27% ± 5% | |
| retina horizontal cell | 5 studies | 23% ± 7% | |
| mast cell | 5 studies | 26% ± 7% | |
| T cell | 5 studies | 25% ± 6% | |
| monocyte | 5 studies | 32% ± 9% | |
| club cell | 5 studies | 33% ± 11% | |
| granule cell | 4 studies | 31% ± 5% | |
| CD4-positive, alpha-beta T cell | 4 studies | 21% ± 3% | |
| cardiac muscle cell | 4 studies | 26% ± 2% | |
| mesothelial cell | 4 studies | 27% ± 7% | |
| lymphocyte | 4 studies | 32% ± 14% | |
| retinal rod cell | 4 studies | 23% ± 6% | |
| connective tissue cell | 4 studies | 19% ± 5% | |
| goblet cell | 4 studies | 34% ± 24% | |
| GABAergic interneuron | 3 studies | 41% ± 3% | |
| glial cell | 3 studies | 27% ± 6% | |
| progenitor cell | 3 studies | 28% ± 3% | |
| retinal ganglion cell | 3 studies | 27% ± 1% | |
| plasma cell | 3 studies | 27% ± 4% | |
| effector memory CD8-positive, alpha-beta T cell | 3 studies | 21% ± 2% | |
| mononuclear phagocyte | 3 studies | 27% ± 5% | |
| GABAergic amacrine cell | 3 studies | 30% ± 7% | |
| Mueller cell | 3 studies | 26% ± 4% | |
| glycinergic amacrine cell | 3 studies | 26% ± 8% | |
| endothelial cell of vascular tree | 3 studies | 31% ± 17% | |
| hepatocyte | 3 studies | 45% ± 21% | |
| retinal pigment epithelial cell | 3 studies | 37% ± 24% | |
| CD8-positive, alpha-beta T cell | 3 studies | 20% ± 3% | |
| abnormal cell | 3 studies | 34% ± 20% | |
| ependymal cell | 3 studies | 36% ± 16% | |
| myofibroblast cell | 3 studies | 31% ± 11% | |
| alveolar macrophage | 3 studies | 40% ± 9% | |
| natural killer cell | 3 studies | 24% ± 4% | |
| respiratory goblet cell | 3 studies | 35% ± 15% | |
| transit amplifying cell | 3 studies | 40% ± 31% | |
| mural cell | 3 studies | 38% ± 12% |
Tissue | GTEx Coverage | GTEx Average TPM | GTEx Number of samples | TCGA Coverage | TCGA Average TPM | TCGA Number of samples |
|---|---|---|---|---|---|---|
| bladder | 100% | 3321.14 | 21 / 21 | 100% | 37.52 | 504 / 504 |
| kidney | 100% | 2604.28 | 89 / 89 | 100% | 32.55 | 901 / 901 |
| prostate | 100% | 3311.87 | 245 / 245 | 100% | 34.86 | 502 / 502 |
| skin | 100% | 7939.88 | 1809 / 1809 | 100% | 40.28 | 472 / 472 |
| thymus | 100% | 3966.25 | 653 / 653 | 100% | 44.80 | 605 / 605 |
| uterus | 100% | 4219.29 | 170 / 170 | 100% | 45.66 | 459 / 459 |
| brain | 100% | 3124.79 | 2638 / 2642 | 100% | 49.08 | 705 / 705 |
| intestine | 100% | 3513.19 | 966 / 966 | 100% | 32.41 | 526 / 527 |
| ovary | 100% | 4201.04 | 180 / 180 | 100% | 38.35 | 429 / 430 |
| stomach | 100% | 2250.45 | 358 / 359 | 100% | 34.05 | 286 / 286 |
| lung | 100% | 2916.32 | 577 / 578 | 100% | 37.85 | 1152 / 1155 |
| adrenal gland | 100% | 2631.91 | 258 / 258 | 100% | 34.67 | 229 / 230 |
| breast | 100% | 3592.55 | 459 / 459 | 99% | 40.83 | 1112 / 1118 |
| esophagus | 100% | 4453.14 | 1445 / 1445 | 99% | 47.59 | 182 / 183 |
| pancreas | 98% | 1512.22 | 321 / 328 | 100% | 31.10 | 178 / 178 |
| liver | 99% | 1494.89 | 224 / 226 | 98% | 18.22 | 397 / 406 |
| adipose | 100% | 3371.44 | 1204 / 1204 | 0% | 0 | 0 / 0 |
| eye | 0% | 0 | 0 / 0 | 100% | 46.07 | 80 / 80 |
| lymph node | 0% | 0 | 0 / 0 | 100% | 21.33 | 29 / 29 |
| spleen | 100% | 4274.93 | 241 / 241 | 0% | 0 | 0 / 0 |
| tonsil | 0% | 0 | 0 / 0 | 100% | 52.20 | 45 / 45 |
| ureter | 0% | 0 | 0 / 0 | 100% | 26.33 | 1 / 1 |
| blood vessel | 100% | 3198.92 | 1333 / 1335 | 0% | 0 | 0 / 0 |
| heart | 97% | 1808.45 | 839 / 861 | 0% | 0 | 0 / 0 |
| muscle | 96% | 1420.53 | 773 / 803 | 0% | 0 | 0 / 0 |
| peripheral blood | 92% | 1798.75 | 859 / 929 | 0% | 0 | 0 / 0 |
| abdomen | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| bone marrow | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| diaphragm | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| gingiva | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nasal cavity | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nasopharynx | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nose | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| placenta | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| spinal column | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| GO_0006465 | Biological process | signal peptide processing |
| GO_0006509 | Biological process | membrane protein ectodomain proteolysis |
| GO_0033619 | Biological process | membrane protein proteolysis |
| GO_0032092 | Biological process | positive regulation of protein binding |
| GO_0070886 | Biological process | positive regulation of calcineurin-NFAT signaling cascade |
| GO_0050852 | Biological process | T cell receptor signaling pathway |
| GO_0007204 | Biological process | positive regulation of cytosolic calcium ion concentration |
| GO_0035307 | Biological process | positive regulation of protein dephosphorylation |
| GO_0005886 | Cellular component | plasma membrane |
| GO_0016020 | Cellular component | membrane |
| GO_0098554 | Cellular component | cytoplasmic side of endoplasmic reticulum membrane |
| GO_0005794 | Cellular component | Golgi apparatus |
| GO_0033116 | Cellular component | endoplasmic reticulum-Golgi intermediate compartment membrane |
| GO_0098553 | Cellular component | lumenal side of endoplasmic reticulum membrane |
| GO_0043231 | Cellular component | intracellular membrane-bounded organelle |
| GO_0030660 | Cellular component | Golgi-associated vesicle membrane |
| GO_0005791 | Cellular component | rough endoplasmic reticulum |
| GO_0042803 | Molecular function | protein homodimerization activity |
| GO_0042500 | Molecular function | aspartic endopeptidase activity, intramembrane cleaving |
| GO_0005515 | Molecular function | protein binding |
| Gene name | SPPL3 |
| Protein name | Signal peptide peptidase-like 3 (SPP-like 3) (EC 3.4.23.-) (Intramembrane protease 2) (IMP-2) (Presenilin homologous protein 1) (PSH1) (Presenilin-like protein 4) Signal peptide peptidase like 3 Alternative protein SPPL3 |
| Synonyms | PSL4 IMP2 |
| Description | FUNCTION: Intramembrane-cleaving aspartic protease (I-CLiP) that cleaves type II membrane protein substrates in or close to their luminal transmembrane domain boundaries . Acts like a sheddase by mediating the proteolytic release and secretion of active site-containing ectodomains of glycan-modifiying glycosidase and glycosyltransferase enzymes such as MGAT5, B4GAT1 and B4GALT1 . Catalyzes the intramembrane cleavage of the envelope glycoprotein gp130 and/or the leader peptide gp18LP of the simian foamy virus independent of prior ectodomain shedding by furin or furin-like proprotein convertase (PC)-mediated cleavage proteolysis . May also have the ability to serve as a shedding protease for subsequent intramembrane proteolysis by SPPL2A and SPPL2B of the envelope glycoprotein gp130 . Plays a role in the regulation of cellular glycosylation processes . Required to link T-cell antigen receptor (TCR) and calcineurin-NFAT signaling cascades in lymphocytes by promoting the association of STIM1 and ORAI1 during store-operated calcium entry (SOCE) in a protease-independent manner . . |
| Accessions | ENST00000353487.7 [Q8TCT6-2] F5H4Y6 ENST00000543181.5 F5H6I1 F5H2A2 F5H7J2 ENST00000543854.5 Q8TCT6 ENST00000543608.5 ENST00000540091.1 L8EBD6 ENST00000536996.5 F5H4L1 |