Name | Number of supported studies | Average coverage | |
---|---|---|---|
astrocyte | 19 studies | 72% ± 22% | |
endothelial cell | 17 studies | 46% ± 17% | |
oligodendrocyte precursor cell | 15 studies | 76% ± 22% | |
pericyte | 14 studies | 57% ± 26% | |
fibroblast | 14 studies | 48% ± 15% | |
glutamatergic neuron | 11 studies | 63% ± 19% | |
smooth muscle cell | 11 studies | 53% ± 17% | |
GABAergic neuron | 10 studies | 57% ± 26% | |
adipocyte | 10 studies | 82% ± 17% | |
microglial cell | 8 studies | 35% ± 21% | |
macrophage | 6 studies | 21% ± 8% | |
neuron | 6 studies | 41% ± 20% | |
interneuron | 6 studies | 47% ± 21% | |
retinal ganglion cell | 6 studies | 63% ± 27% | |
ciliated cell | 5 studies | 37% ± 19% | |
type I pneumocyte | 5 studies | 36% ± 16% | |
type II pneumocyte | 5 studies | 52% ± 20% | |
hepatocyte | 4 studies | 66% ± 32% | |
epithelial cell | 4 studies | 36% ± 7% | |
mesothelial cell | 4 studies | 46% ± 24% | |
Mueller cell | 4 studies | 51% ± 27% | |
oligodendrocyte | 4 studies | 39% ± 25% | |
hepatic stellate cell | 3 studies | 56% ± 28% | |
differentiation-committed oligodendrocyte precursor | 3 studies | 63% ± 13% | |
GABAergic interneuron | 3 studies | 44% ± 18% | |
glial cell | 3 studies | 31% ± 13% | |
granule cell | 3 studies | 28% ± 13% | |
progenitor cell | 3 studies | 57% ± 31% | |
cardiac muscle cell | 3 studies | 20% ± 3% | |
GABAergic amacrine cell | 3 studies | 66% ± 5% | |
ON-bipolar cell | 3 studies | 67% ± 19% | |
glycinergic amacrine cell | 3 studies | 42% ± 27% | |
amacrine cell | 3 studies | 55% ± 27% | |
ependymal cell | 3 studies | 77% ± 9% | |
chondrocyte | 3 studies | 55% ± 31% | |
club cell | 3 studies | 47% ± 12% | |
endothelial cell of artery | 3 studies | 43% ± 12% | |
respiratory goblet cell | 3 studies | 48% ± 17% | |
basal cell | 3 studies | 30% ± 17% |
Tissue | GTEx Coverage | GTEx Average TPM | GTEx Number of samples | TCGA Coverage | TCGA Average TPM | TCGA Number of samples |
---|---|---|---|---|---|---|
brain | 95% | 633.10 | 2523 / 2642 | 95% | 8.62 | 672 / 705 |
ovary | 100% | 773.74 | 180 / 180 | 83% | 3.78 | 357 / 430 |
liver | 99% | 745.86 | 224 / 226 | 70% | 1.89 | 284 / 406 |
skin | 73% | 645.20 | 1319 / 1809 | 94% | 10.60 | 443 / 472 |
breast | 100% | 758.22 | 457 / 459 | 32% | 1.05 | 361 / 1118 |
lung | 98% | 493.95 | 566 / 578 | 33% | 0.91 | 384 / 1155 |
prostate | 95% | 368.57 | 233 / 245 | 28% | 0.43 | 143 / 502 |
uterus | 99% | 764.60 | 169 / 170 | 22% | 0.70 | 102 / 459 |
thymus | 99% | 475.65 | 646 / 653 | 13% | 0.26 | 79 / 605 |
bladder | 95% | 588.19 | 20 / 21 | 8% | 0.21 | 38 / 504 |
blood vessel | 100% | 1190.78 | 1334 / 1335 | 0% | 0 | 0 / 0 |
adipose | 100% | 992.55 | 1202 / 1204 | 0% | 0 | 0 / 0 |
intestine | 89% | 356.36 | 860 / 966 | 10% | 0.22 | 54 / 527 |
esophagus | 64% | 236.80 | 923 / 1445 | 28% | 0.73 | 52 / 183 |
stomach | 68% | 429.60 | 244 / 359 | 21% | 0.50 | 61 / 286 |
kidney | 51% | 133.58 | 45 / 89 | 36% | 0.76 | 324 / 901 |
spleen | 80% | 234.07 | 192 / 241 | 0% | 0 | 0 / 0 |
adrenal gland | 9% | 15.40 | 23 / 258 | 46% | 0.95 | 105 / 230 |
heart | 54% | 150.06 | 462 / 861 | 0% | 0 | 0 / 0 |
pancreas | 9% | 15.40 | 30 / 328 | 37% | 0.70 | 65 / 178 |
lymph node | 0% | 0 | 0 / 0 | 38% | 1.94 | 11 / 29 |
eye | 0% | 0 | 0 / 0 | 36% | 1.09 | 29 / 80 |
muscle | 15% | 30.99 | 124 / 803 | 0% | 0 | 0 / 0 |
tonsil | 0% | 0 | 0 / 0 | 9% | 0.17 | 4 / 45 |
peripheral blood | 5% | 21.10 | 46 / 929 | 0% | 0 | 0 / 0 |
abdomen | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
bone marrow | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
diaphragm | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
gingiva | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
nasal cavity | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
nasopharynx | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
nose | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
placenta | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
spinal column | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
ureter | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 1 |
GO_0055059 | Biological process | asymmetric neuroblast division |
GO_0006366 | Biological process | transcription by RNA polymerase II |
GO_0002062 | Biological process | chondrocyte differentiation |
GO_0032332 | Biological process | positive regulation of chondrocyte differentiation |
GO_0071560 | Biological process | cellular response to transforming growth factor beta stimulus |
GO_0001502 | Biological process | cartilage condensation |
GO_0045165 | Biological process | cell fate commitment |
GO_0051216 | Biological process | cartilage development |
GO_0061036 | Biological process | positive regulation of cartilage development |
GO_2000741 | Biological process | positive regulation of mesenchymal stem cell differentiation |
GO_0006357 | Biological process | regulation of transcription by RNA polymerase II |
GO_0000785 | Cellular component | chromatin |
GO_0005634 | Cellular component | nucleus |
GO_0000978 | Molecular function | RNA polymerase II cis-regulatory region sequence-specific DNA binding |
GO_0003700 | Molecular function | DNA-binding transcription factor activity |
GO_0005515 | Molecular function | protein binding |
GO_0000981 | Molecular function | DNA-binding transcription factor activity, RNA polymerase II-specific |
GO_0000976 | Molecular function | transcription cis-regulatory region binding |
Gene name | SOX5 |
Protein name | Transcription factor SOX-5 variant 6 SRY-box transcription factor 5 (Transcription factor SOX-5 variant 7) SRY-box transcription factor 5 SOX5 protein SRY (Sex determining region Y)-box 5, isoform CRA_f (SRY-box transcription factor 5) Transcription factor SOX-5 |
Synonyms | hCG_1811069 |
Description | FUNCTION: Transcription factor involved in chondrocytes differentiation and cartilage formation. Specifically binds the 5'-AACAAT-3' DNA motif present in enhancers and super-enhancers and promotes expression of genes important for chondrogenesis, including cartilage matrix protein-coding genes, such as COL2A1 and AGC1. Required for overt chondrogenesis when condensed prechondrocytes differentiate into early stage chondrocytes: SOX5 and SOX6 cooperatively bind with SOX9 on active enhancers and super-enhancers associated with cartilage-specific genes, and thereby potentiate SOX9's ability to transactivate. Not involved in precartilaginous condensation, the first step in chondrogenesis, during which skeletal progenitors differentiate into prechondrocytes. Together with SOX6, required to form and maintain a pool of highly proliferating chondroblasts between epiphyses and metaphyses, to form columnar chondroblasts, delay chondrocyte prehypertrophy but promote hypertrophy, and to delay terminal differentiation of chondrocytes on contact with ossification fronts. Binds to the proximal promoter region of the myelin protein MPZ gene. . |
Accessions | F5GWL1 ENST00000646273.1 [P35711-4] A0A994J7C0 A0A2R8Y5Q1 T2CYZ2 A0A994J4I4 ENST00000451604.7 [P35711-1] ENST00000537393.5 I3L0A5 A0A994J4A9 ENST00000446891.7 ENST00000704298.1 ENST00000367206.7 G3V0H1 ENST00000704299.1 A0A2R8Y7P3 ENST00000538083.1 T2CZM2 Q6IBT9 ENST00000396007.6 [P35711-3] ENST00000704296.1 ENST00000441133.2 ENST00000704300.1 P35711 ENST00000545921.5 [P35711-5] F5H0I3 ENST00000704297.1 A0A994J6X9 ENST00000536729.2 |