SOX5 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0055059Biological processasymmetric neuroblast division
GO_0006366Biological processtranscription by RNA polymerase II
GO_0002062Biological processchondrocyte differentiation
GO_0032332Biological processpositive regulation of chondrocyte differentiation
GO_0071560Biological processcellular response to transforming growth factor beta stimulus
GO_0001502Biological processcartilage condensation
GO_0045165Biological processcell fate commitment
GO_0051216Biological processcartilage development
GO_0061036Biological processpositive regulation of cartilage development
GO_2000741Biological processpositive regulation of mesenchymal stem cell differentiation
GO_0006357Biological processregulation of transcription by RNA polymerase II
GO_0000785Cellular componentchromatin
GO_0005634Cellular componentnucleus
GO_0000978Molecular functionRNA polymerase II cis-regulatory region sequence-specific DNA binding
GO_0003700Molecular functionDNA-binding transcription factor activity
GO_0005515Molecular functionprotein binding
GO_0000981Molecular functionDNA-binding transcription factor activity, RNA polymerase II-specific
GO_0000976Molecular functiontranscription cis-regulatory region binding

IV. Literature review

[source]
Gene nameSOX5
Protein nameTranscription factor SOX-5 variant 6
SRY-box transcription factor 5 (Transcription factor SOX-5 variant 7)
SRY-box transcription factor 5
SOX5 protein
SRY (Sex determining region Y)-box 5, isoform CRA_f (SRY-box transcription factor 5)
Transcription factor SOX-5
SynonymshCG_1811069
DescriptionFUNCTION: Transcription factor involved in chondrocytes differentiation and cartilage formation. Specifically binds the 5'-AACAAT-3' DNA motif present in enhancers and super-enhancers and promotes expression of genes important for chondrogenesis, including cartilage matrix protein-coding genes, such as COL2A1 and AGC1. Required for overt chondrogenesis when condensed prechondrocytes differentiate into early stage chondrocytes: SOX5 and SOX6 cooperatively bind with SOX9 on active enhancers and super-enhancers associated with cartilage-specific genes, and thereby potentiate SOX9's ability to transactivate. Not involved in precartilaginous condensation, the first step in chondrogenesis, during which skeletal progenitors differentiate into prechondrocytes. Together with SOX6, required to form and maintain a pool of highly proliferating chondroblasts between epiphyses and metaphyses, to form columnar chondroblasts, delay chondrocyte prehypertrophy but promote hypertrophy, and to delay terminal differentiation of chondrocytes on contact with ossification fronts. Binds to the proximal promoter region of the myelin protein MPZ gene. .

AccessionsF5GWL1
ENST00000646273.1 [P35711-4]
A0A994J7C0
A0A2R8Y5Q1
T2CYZ2
A0A994J4I4
ENST00000451604.7 [P35711-1]
ENST00000537393.5
I3L0A5
A0A994J4A9
ENST00000446891.7
ENST00000704298.1
ENST00000367206.7
G3V0H1
ENST00000704299.1
A0A2R8Y7P3
ENST00000538083.1
T2CZM2
Q6IBT9
ENST00000396007.6 [P35711-3]
ENST00000704296.1
ENST00000441133.2
ENST00000704300.1
P35711
ENST00000545921.5 [P35711-5]
F5H0I3
ENST00000704297.1
A0A994J6X9
ENST00000536729.2