SMURF1 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0016567Biological processprotein ubiquitination
GO_0072659Biological processprotein localization to plasma membrane
GO_0006611Biological processprotein export from nucleus
GO_0000209Biological processprotein polyubiquitination
GO_0030512Biological processnegative regulation of transforming growth factor beta receptor signaling pathway
GO_0045773Biological processpositive regulation of axon extension
GO_0006511Biological processubiquitin-dependent protein catabolic process
GO_0071211Biological processprotein targeting to vacuole involved in autophagy
GO_1903861Biological processpositive regulation of dendrite extension
GO_0030514Biological processnegative regulation of BMP signaling pathway
GO_0032926Biological processnegative regulation of activin receptor signaling pathway
GO_0007398Biological processectoderm development
GO_0030509Biological processBMP signaling pathway
GO_2000060Biological processpositive regulation of ubiquitin-dependent protein catabolic process
GO_0030154Biological processcell differentiation
GO_0060071Biological processWnt signaling pathway, planar cell polarity pathway
GO_0061753Biological processsubstrate localization to autophagosome
GO_0043161Biological processproteasome-mediated ubiquitin-dependent protein catabolic process
GO_0032801Biological processreceptor catabolic process
GO_0061736Biological processengulfment of target by autophagosome
GO_0005886Cellular componentplasma membrane
GO_0005739Cellular componentmitochondrion
GO_0070062Cellular componentextracellular exosome
GO_0005654Cellular componentnucleoplasm
GO_0043025Cellular componentneuronal cell body
GO_0005829Cellular componentcytosol
GO_0005737Cellular componentcytoplasm
GO_0030424Cellular componentaxon
GO_0061630Molecular functionubiquitin protein ligase activity
GO_0070412Molecular functionR-SMAD binding
GO_0070697Molecular functionactivin receptor binding
GO_0005543Molecular functionphospholipid binding
GO_0046332Molecular functionSMAD binding
GO_0070411Molecular functionI-SMAD binding
GO_0004842Molecular functionubiquitin-protein transferase activity
GO_0005160Molecular functiontransforming growth factor beta receptor binding
GO_0005515Molecular functionprotein binding

IV. Literature review

[source]
Gene nameSMURF1
Protein nameE3 ubiquitin-protein ligase SMURF1 (hSMURF1) (EC 2.3.2.26) (HECT-type E3 ubiquitin transferase SMURF1) (SMAD ubiquitination regulatory factor 1) (SMAD-specific E3 ubiquitin-protein ligase 1)
SynonymsKIAA1625
DescriptionFUNCTION: E3 ubiquitin-protein ligase that acts as a negative regulator of BMP signaling pathway. Mediates ubiquitination and degradation of SMAD1 and SMAD5, 2 receptor-regulated SMADs specific for the BMP pathway. Promotes ubiquitination and subsequent proteasomal degradation of TRAF family members and RHOA. Promotes ubiquitination and subsequent proteasomal degradation of MAVS . Acts as an antagonist of TGF-beta signaling by ubiquitinating TGFBR1 and targeting it for degradation . Plays a role in dendrite formation by melanocytes . .

AccessionsENST00000361125.1 [Q9HCE7-1]
Q9HCE7
ENST00000361368.7 [Q9HCE7-2]