Name | Number of supported studies | Average coverage | |
---|---|---|---|
endothelial cell | 15 studies | 33% ± 12% | |
oligodendrocyte | 14 studies | 38% ± 12% | |
fibroblast | 12 studies | 33% ± 14% | |
microglial cell | 11 studies | 36% ± 10% | |
astrocyte | 11 studies | 33% ± 13% | |
pericyte | 10 studies | 32% ± 15% | |
oligodendrocyte precursor cell | 10 studies | 27% ± 11% | |
glutamatergic neuron | 9 studies | 39% ± 25% | |
adipocyte | 9 studies | 39% ± 7% | |
macrophage | 8 studies | 28% ± 8% | |
smooth muscle cell | 7 studies | 30% ± 11% | |
GABAergic neuron | 7 studies | 43% ± 19% | |
interneuron | 6 studies | 38% ± 21% | |
ciliated cell | 6 studies | 34% ± 17% | |
endothelial cell of lymphatic vessel | 6 studies | 26% ± 8% | |
type I pneumocyte | 6 studies | 46% ± 14% | |
neuron | 5 studies | 39% ± 16% | |
epithelial cell | 5 studies | 33% ± 16% | |
dendritic cell | 5 studies | 19% ± 3% | |
mast cell | 5 studies | 19% ± 3% | |
monocyte | 5 studies | 28% ± 9% | |
club cell | 5 studies | 37% ± 14% | |
basal cell | 5 studies | 44% ± 17% | |
type II pneumocyte | 5 studies | 42% ± 6% | |
retina horizontal cell | 4 studies | 31% ± 8% | |
GABAergic interneuron | 3 studies | 23% ± 6% | |
granule cell | 3 studies | 19% ± 2% | |
amacrine cell | 3 studies | 20% ± 4% | |
myeloid cell | 3 studies | 20% ± 3% | |
endothelial cell of vascular tree | 3 studies | 27% ± 12% | |
hepatocyte | 3 studies | 46% ± 12% | |
ependymal cell | 3 studies | 30% ± 9% | |
T cell | 3 studies | 25% ± 10% | |
alveolar macrophage | 3 studies | 37% ± 11% | |
respiratory goblet cell | 3 studies | 47% ± 16% | |
lymphocyte | 3 studies | 23% ± 5% | |
muscle cell | 3 studies | 32% ± 16% | |
mesothelial cell | 3 studies | 29% ± 3% | |
mucus secreting cell | 3 studies | 40% ± 8% |
Tissue | GTEx Coverage | GTEx Average TPM | GTEx Number of samples | TCGA Coverage | TCGA Average TPM | TCGA Number of samples |
---|---|---|---|---|---|---|
esophagus | 100% | 3480.83 | 1445 / 1445 | 100% | 48.65 | 183 / 183 |
lung | 100% | 4738.83 | 578 / 578 | 100% | 36.02 | 1153 / 1155 |
stomach | 100% | 3088.43 | 359 / 359 | 100% | 29.66 | 285 / 286 |
bladder | 100% | 3180.24 | 21 / 21 | 100% | 26.23 | 502 / 504 |
skin | 100% | 4194.79 | 1809 / 1809 | 100% | 25.62 | 470 / 472 |
ovary | 100% | 5010.31 | 180 / 180 | 100% | 19.55 | 428 / 430 |
breast | 100% | 3805.35 | 459 / 459 | 99% | 21.98 | 1112 / 1118 |
intestine | 100% | 3080.02 | 966 / 966 | 99% | 27.41 | 524 / 527 |
pancreas | 100% | 2182.16 | 327 / 328 | 99% | 39.90 | 177 / 178 |
uterus | 100% | 3232.21 | 170 / 170 | 99% | 23.27 | 454 / 459 |
prostate | 100% | 3613.08 | 245 / 245 | 98% | 17.36 | 494 / 502 |
kidney | 100% | 2644.79 | 89 / 89 | 98% | 20.73 | 886 / 901 |
brain | 97% | 1791.50 | 2572 / 2642 | 100% | 17.53 | 703 / 705 |
thymus | 100% | 2344.39 | 652 / 653 | 95% | 11.79 | 573 / 605 |
liver | 100% | 1534.70 | 226 / 226 | 93% | 14.94 | 379 / 406 |
adrenal gland | 100% | 3169.47 | 258 / 258 | 84% | 11.97 | 193 / 230 |
adipose | 100% | 4079.66 | 1204 / 1204 | 0% | 0 | 0 / 0 |
blood vessel | 100% | 6153.89 | 1335 / 1335 | 0% | 0 | 0 / 0 |
spleen | 100% | 2565.19 | 241 / 241 | 0% | 0 | 0 / 0 |
ureter | 0% | 0 | 0 / 0 | 100% | 14.40 | 1 / 1 |
muscle | 99% | 1800.43 | 798 / 803 | 0% | 0 | 0 / 0 |
eye | 0% | 0 | 0 / 0 | 99% | 17.31 | 79 / 80 |
tonsil | 0% | 0 | 0 / 0 | 98% | 26.17 | 44 / 45 |
heart | 96% | 1417.68 | 829 / 861 | 0% | 0 | 0 / 0 |
lymph node | 0% | 0 | 0 / 0 | 86% | 9.55 | 25 / 29 |
peripheral blood | 79% | 973.19 | 732 / 929 | 0% | 0 | 0 / 0 |
abdomen | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
bone marrow | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
diaphragm | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
gingiva | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
nasal cavity | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
nasopharynx | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
nose | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
placenta | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
spinal column | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
GO_0016567 | Biological process | protein ubiquitination |
GO_0072659 | Biological process | protein localization to plasma membrane |
GO_0006611 | Biological process | protein export from nucleus |
GO_0000209 | Biological process | protein polyubiquitination |
GO_0030512 | Biological process | negative regulation of transforming growth factor beta receptor signaling pathway |
GO_0045773 | Biological process | positive regulation of axon extension |
GO_0006511 | Biological process | ubiquitin-dependent protein catabolic process |
GO_0071211 | Biological process | protein targeting to vacuole involved in autophagy |
GO_1903861 | Biological process | positive regulation of dendrite extension |
GO_0030514 | Biological process | negative regulation of BMP signaling pathway |
GO_0032926 | Biological process | negative regulation of activin receptor signaling pathway |
GO_0007398 | Biological process | ectoderm development |
GO_0030509 | Biological process | BMP signaling pathway |
GO_2000060 | Biological process | positive regulation of ubiquitin-dependent protein catabolic process |
GO_0030154 | Biological process | cell differentiation |
GO_0060071 | Biological process | Wnt signaling pathway, planar cell polarity pathway |
GO_0061753 | Biological process | substrate localization to autophagosome |
GO_0043161 | Biological process | proteasome-mediated ubiquitin-dependent protein catabolic process |
GO_0032801 | Biological process | receptor catabolic process |
GO_0061736 | Biological process | engulfment of target by autophagosome |
GO_0005886 | Cellular component | plasma membrane |
GO_0005739 | Cellular component | mitochondrion |
GO_0070062 | Cellular component | extracellular exosome |
GO_0005654 | Cellular component | nucleoplasm |
GO_0043025 | Cellular component | neuronal cell body |
GO_0005829 | Cellular component | cytosol |
GO_0005737 | Cellular component | cytoplasm |
GO_0030424 | Cellular component | axon |
GO_0061630 | Molecular function | ubiquitin protein ligase activity |
GO_0070412 | Molecular function | R-SMAD binding |
GO_0070697 | Molecular function | activin receptor binding |
GO_0005543 | Molecular function | phospholipid binding |
GO_0046332 | Molecular function | SMAD binding |
GO_0070411 | Molecular function | I-SMAD binding |
GO_0004842 | Molecular function | ubiquitin-protein transferase activity |
GO_0005160 | Molecular function | transforming growth factor beta receptor binding |
GO_0005515 | Molecular function | protein binding |
Gene name | SMURF1 |
Protein name | E3 ubiquitin-protein ligase SMURF1 (hSMURF1) (EC 2.3.2.26) (HECT-type E3 ubiquitin transferase SMURF1) (SMAD ubiquitination regulatory factor 1) (SMAD-specific E3 ubiquitin-protein ligase 1) |
Synonyms | KIAA1625 |
Description | FUNCTION: E3 ubiquitin-protein ligase that acts as a negative regulator of BMP signaling pathway. Mediates ubiquitination and degradation of SMAD1 and SMAD5, 2 receptor-regulated SMADs specific for the BMP pathway. Promotes ubiquitination and subsequent proteasomal degradation of TRAF family members and RHOA. Promotes ubiquitination and subsequent proteasomal degradation of MAVS . Acts as an antagonist of TGF-beta signaling by ubiquitinating TGFBR1 and targeting it for degradation . Plays a role in dendrite formation by melanocytes . . |
Accessions | ENST00000361125.1 [Q9HCE7-1] Q9HCE7 ENST00000361368.7 [Q9HCE7-2] |