SMC1A report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0034089Biological processestablishment of meiotic sister chromatid cohesion
GO_0007062Biological processsister chromatid cohesion
GO_0006281Biological processDNA repair
GO_0000070Biological processmitotic sister chromatid segregation
GO_0007064Biological processmitotic sister chromatid cohesion
GO_0009314Biological processresponse to radiation
GO_0051301Biological processcell division
GO_0034087Biological processestablishment of mitotic sister chromatid cohesion
GO_0090307Biological processmitotic spindle assembly
GO_0051321Biological processmeiotic cell cycle
GO_0072423Biological processresponse to DNA damage checkpoint signaling
GO_0035019Biological processsomatic stem cell population maintenance
GO_0000775Cellular componentchromosome, centromeric region
GO_0097431Cellular componentmitotic spindle pole
GO_0008278Cellular componentcohesin complex
GO_0000776Cellular componentkinetochore
GO_0005654Cellular componentnucleoplasm
GO_0016363Cellular componentnuclear matrix
GO_0005829Cellular componentcytosol
GO_0030892Cellular componentmitotic cohesin complex
GO_0030893Cellular componentmeiotic cohesin complex
GO_0005694Cellular componentchromosome
GO_0000794Cellular componentcondensed nuclear chromosome
GO_0005634Cellular componentnucleus
GO_0003677Molecular functionDNA binding
GO_0003682Molecular functionchromatin binding
GO_0005524Molecular functionATP binding
GO_0003723Molecular functionRNA binding
GO_0046982Molecular functionprotein heterodimerization activity
GO_0036033Molecular functionmediator complex binding
GO_0005515Molecular functionprotein binding
GO_0016887Molecular functionATP hydrolysis activity

IV. Literature review

[source]
Gene nameSMC1A
Protein nameStructural maintenance of chromosomes 1A
SMC1A protein
Structural maintenance of chromosomes protein 1A (SMC protein 1A) (SMC-1-alpha) (SMC-1A) (Sb1.8)
Structural maintenance of chromosomes protein 1A
Structural maintenance of chromosomes protein
SynonymsSMC1
KIAA0178
RP6-29D12.1-003
SMC1L1
SB1.8
DXS423E
DescriptionFUNCTION: Involved in chromosome cohesion during cell cycle and in DNA repair. Central component of cohesin complex. The cohesin complex is required for the cohesion of sister chromatids after DNA replication. The cohesin complex apparently forms a large proteinaceous ring within which sister chromatids can be trapped. At anaphase, the complex is cleaved and dissociates from chromatin, allowing sister chromatids to segregate. The cohesin complex may also play a role in spindle pole assembly during mitosis. Involved in DNA repair via its interaction with BRCA1 and its related phosphorylation by ATM, or via its phosphorylation by ATR. Works as a downstream effector both in the ATM/NBS1 branch and in the ATR/MSH2 branch of S-phase checkpoint. .

AccessionsA0A6Q8PHC3
V9GYN9
ENST00000675504.1
ENST00000463684.1
Q68EN4
ENST00000322213.9
ENST00000470241.2
G8JLG1
Q14683
ENST00000674590.1
V9GY57
Q5H934
ENST00000375340.10
Q6P2R1