Name | Number of supported studies | Average coverage | |
---|---|---|---|
smooth muscle cell | 22 studies | 31% ± 7% | |
pericyte | 18 studies | 29% ± 19% | |
ciliated cell | 16 studies | 34% ± 11% | |
endothelial cell | 11 studies | 24% ± 10% | |
cardiac muscle cell | 7 studies | 59% ± 18% | |
type I pneumocyte | 6 studies | 28% ± 10% | |
plasma cell | 6 studies | 29% ± 12% | |
ionocyte | 6 studies | 29% ± 10% | |
kidney loop of Henle epithelial cell | 6 studies | 50% ± 17% | |
neuron | 6 studies | 31% ± 15% | |
amacrine cell | 6 studies | 44% ± 20% | |
retinal ganglion cell | 6 studies | 69% ± 30% | |
retinal rod cell | 6 studies | 37% ± 15% | |
retinal cone cell | 6 studies | 49% ± 25% | |
basal cell | 6 studies | 29% ± 12% | |
type II pneumocyte | 5 studies | 37% ± 15% | |
epithelial cell of proximal tubule | 5 studies | 21% ± 8% | |
renal alpha-intercalated cell | 5 studies | 61% ± 10% | |
astrocyte | 5 studies | 50% ± 18% | |
epithelial cell | 5 studies | 40% ± 9% | |
fibroblast | 5 studies | 26% ± 7% | |
GABAergic neuron | 5 studies | 36% ± 12% | |
plasmablast | 4 studies | 42% ± 22% | |
deuterosomal cell | 4 studies | 18% ± 3% | |
pancreatic A cell | 4 studies | 45% ± 18% | |
OFF-bipolar cell | 4 studies | 51% ± 31% | |
ON-bipolar cell | 4 studies | 47% ± 32% | |
retina horizontal cell | 4 studies | 52% ± 16% | |
retinal pigment epithelial cell | 4 studies | 43% ± 23% | |
Mueller cell | 4 studies | 54% ± 17% | |
glutamatergic neuron | 4 studies | 46% ± 15% | |
oligodendrocyte precursor cell | 4 studies | 29% ± 16% | |
pancreatic D cell | 3 studies | 48% ± 25% | |
type B pancreatic cell | 3 studies | 57% ± 16% | |
retinal bipolar neuron | 3 studies | 51% ± 17% | |
GABAergic amacrine cell | 3 studies | 39% ± 10% | |
glycinergic amacrine cell | 3 studies | 31% ± 11% | |
kidney distal convoluted tubule epithelial cell | 3 studies | 47% ± 7% | |
rod bipolar cell | 3 studies | 43% ± 17% | |
oligodendrocyte | 3 studies | 21% ± 5% | |
muscle cell | 3 studies | 41% ± 14% | |
pancreatic ductal cell | 3 studies | 43% ± 22% | |
goblet cell | 3 studies | 18% ± 2% | |
secretory cell | 3 studies | 26% ± 11% | |
interneuron | 3 studies | 34% ± 13% |
Tissue | GTEx Coverage | GTEx Average TPM | GTEx Number of samples | TCGA Coverage | TCGA Average TPM | TCGA Number of samples |
---|---|---|---|---|---|---|
kidney | 98% | 5300.13 | 87 / 89 | 99% | 48.39 | 893 / 901 |
brain | 95% | 8246.45 | 2504 / 2642 | 100% | 71.27 | 704 / 705 |
stomach | 99% | 7207.68 | 356 / 359 | 93% | 19.85 | 265 / 286 |
thymus | 88% | 3111.83 | 574 / 653 | 100% | 42.91 | 602 / 605 |
prostate | 85% | 4269.22 | 208 / 245 | 100% | 49.07 | 501 / 502 |
intestine | 88% | 7437.14 | 854 / 966 | 96% | 21.85 | 507 / 527 |
adrenal gland | 85% | 3009.43 | 220 / 258 | 99% | 59.48 | 227 / 230 |
bladder | 76% | 4850.48 | 16 / 21 | 93% | 20.30 | 469 / 504 |
uterus | 66% | 2199.76 | 112 / 170 | 96% | 25.85 | 441 / 459 |
breast | 65% | 1995.35 | 300 / 459 | 93% | 23.15 | 1044 / 1118 |
esophagus | 73% | 7862.98 | 1050 / 1445 | 84% | 13.63 | 154 / 183 |
lung | 60% | 2164.60 | 344 / 578 | 97% | 23.22 | 1116 / 1155 |
liver | 55% | 1704.18 | 124 / 226 | 99% | 28.42 | 400 / 406 |
ovary | 52% | 1565.22 | 94 / 180 | 99% | 25.67 | 427 / 430 |
pancreas | 15% | 380.79 | 48 / 328 | 99% | 21.02 | 177 / 178 |
skin | 11% | 343.54 | 201 / 1809 | 99% | 55.96 | 466 / 472 |
muscle | 100% | 65658.31 | 803 / 803 | 0% | 0 | 0 / 0 |
ureter | 0% | 0 | 0 / 0 | 100% | 9.23 | 1 / 1 |
heart | 99% | 84110.05 | 855 / 861 | 0% | 0 | 0 / 0 |
blood vessel | 99% | 10032.81 | 1324 / 1335 | 0% | 0 | 0 / 0 |
tonsil | 0% | 0 | 0 / 0 | 98% | 22.86 | 44 / 45 |
eye | 0% | 0 | 0 / 0 | 95% | 28.44 | 76 / 80 |
lymph node | 0% | 0 | 0 / 0 | 90% | 19.39 | 26 / 29 |
adipose | 62% | 1911.17 | 746 / 1204 | 0% | 0 | 0 / 0 |
peripheral blood | 16% | 609.47 | 148 / 929 | 0% | 0 | 0 / 0 |
spleen | 7% | 180.97 | 17 / 241 | 0% | 0 | 0 / 0 |
abdomen | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
bone marrow | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
diaphragm | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
gingiva | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
nasal cavity | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
nasopharynx | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
nose | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
placenta | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
spinal column | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
GO_0006091 | Biological process | generation of precursor metabolites and energy |
GO_0015866 | Biological process | ADP transport |
GO_1901029 | Biological process | negative regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway |
GO_1990845 | Biological process | adaptive thermogenesis |
GO_0008637 | Biological process | apoptotic mitochondrial changes |
GO_0015853 | Biological process | adenine transport |
GO_0060546 | Biological process | negative regulation of necroptotic process |
GO_1901526 | Biological process | positive regulation of mitophagy |
GO_1990544 | Biological process | mitochondrial ATP transmembrane transport |
GO_0046902 | Biological process | regulation of mitochondrial membrane permeability |
GO_0000002 | Biological process | mitochondrial genome maintenance |
GO_1902600 | Biological process | proton transmembrane transport |
GO_0140021 | Biological process | mitochondrial ADP transmembrane transport |
GO_0005886 | Cellular component | plasma membrane |
GO_0016020 | Cellular component | membrane |
GO_0005739 | Cellular component | mitochondrion |
GO_0031966 | Cellular component | mitochondrial membrane |
GO_0005743 | Cellular component | mitochondrial inner membrane |
GO_0005757 | Cellular component | mitochondrial permeability transition pore complex |
GO_0015078 | Molecular function | proton transmembrane transporter activity |
GO_0015207 | Molecular function | adenine transmembrane transporter activity |
GO_0005471 | Molecular function | ATP:ADP antiporter activity |
GO_0017077 | Molecular function | oxidative phosphorylation uncoupler activity |
GO_0005515 | Molecular function | protein binding |
Gene name | SLC25A4 |
Protein name | ADP/ATP translocase 1 (ADP,ATP carrier protein 1) (ADP,ATP carrier protein, heart/skeletal muscle isoform T1) (Adenine nucleotide translocator 1) (ANT 1) (Solute carrier family 25 member 4) ADP/ATP translocase (ADP,ATP carrier protein) |
Synonyms | AAC1 ANT1 |
Description | FUNCTION: ADP:ATP antiporter that mediates import of ADP into the mitochondrial matrix for ATP synthesis, and export of ATP out to fuel the cell . Cycles between the cytoplasmic-open state (c-state) and the matrix-open state (m-state): operates by the alternating access mechanism with a single substrate-binding site intermittently exposed to either the cytosolic (c-state) or matrix (m-state) side of the inner mitochondrial membrane (By similarity). In addition to its ADP:ATP antiporter activity, also involved in mitochondrial uncoupling and mitochondrial permeability transition pore (mPTP) activity . Plays a role in mitochondrial uncoupling by acting as a proton transporter: proton transport uncouples the proton flows via the electron transport chain and ATP synthase to reduce the efficiency of ATP production and cause mitochondrial thermogenesis (By similarity). Proton transporter activity is inhibited by ADP:ATP antiporter activity, suggesting that SLC25A4/ANT1 acts as a master regulator of mitochondrial energy output by maintaining a delicate balance between ATP production (ADP:ATP antiporter activity) and thermogenesis (proton transporter activity) (By similarity). Proton transporter activity requires free fatty acids as cofactor, but does not transport it (By similarity). Also plays a key role in mPTP opening, a non-specific pore that enables free passage of the mitochondrial membranes to solutes of up to 1.5 kDa, and which contributes to cell death . It is however unclear if SLC25A4/ANT1 constitutes a pore-forming component of mPTP or regulates it (By similarity). Acts as a regulator of mitophagy independently of ADP:ATP antiporter activity: promotes mitophagy via interaction with TIMM44, leading to inhibit the presequence translocase TIMM23, thereby promoting stabilization of PINK1 (By similarity). . FUNCTION: Catalyzes the exchange of ADP and ATP across the membrane. . FUNCTION: Catalyzes the exchange of ADP and ATP across the membrane. . FUNCTION: Catalyzes the exchange of ADP and ATP across the membrane. . FUNCTION: Catalyzes the exchange of ADP and ATP across the membrane. . |
Accessions | A0A0S2Z359 P12235 ENST00000491736.1 A0A0S2Z3H3 V9GYG0 A0A0S2Z3C4 ENST00000281456.11 |