SLC25A4 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0006091Biological processgeneration of precursor metabolites and energy
GO_0015866Biological processADP transport
GO_1901029Biological processnegative regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway
GO_1990845Biological processadaptive thermogenesis
GO_0008637Biological processapoptotic mitochondrial changes
GO_0015853Biological processadenine transport
GO_0060546Biological processnegative regulation of necroptotic process
GO_1901526Biological processpositive regulation of mitophagy
GO_1990544Biological processmitochondrial ATP transmembrane transport
GO_0046902Biological processregulation of mitochondrial membrane permeability
GO_0000002Biological processmitochondrial genome maintenance
GO_1902600Biological processproton transmembrane transport
GO_0140021Biological processmitochondrial ADP transmembrane transport
GO_0005886Cellular componentplasma membrane
GO_0016020Cellular componentmembrane
GO_0005739Cellular componentmitochondrion
GO_0031966Cellular componentmitochondrial membrane
GO_0005743Cellular componentmitochondrial inner membrane
GO_0005757Cellular componentmitochondrial permeability transition pore complex
GO_0015078Molecular functionproton transmembrane transporter activity
GO_0015207Molecular functionadenine transmembrane transporter activity
GO_0005471Molecular functionATP:ADP antiporter activity
GO_0017077Molecular functionoxidative phosphorylation uncoupler activity
GO_0005515Molecular functionprotein binding

IV. Literature review

[source]
Gene nameSLC25A4
Protein nameADP/ATP translocase 1 (ADP,ATP carrier protein 1) (ADP,ATP carrier protein, heart/skeletal muscle isoform T1) (Adenine nucleotide translocator 1) (ANT 1) (Solute carrier family 25 member 4)
ADP/ATP translocase (ADP,ATP carrier protein)
SynonymsAAC1
ANT1
DescriptionFUNCTION: ADP:ATP antiporter that mediates import of ADP into the mitochondrial matrix for ATP synthesis, and export of ATP out to fuel the cell . Cycles between the cytoplasmic-open state (c-state) and the matrix-open state (m-state): operates by the alternating access mechanism with a single substrate-binding site intermittently exposed to either the cytosolic (c-state) or matrix (m-state) side of the inner mitochondrial membrane (By similarity). In addition to its ADP:ATP antiporter activity, also involved in mitochondrial uncoupling and mitochondrial permeability transition pore (mPTP) activity . Plays a role in mitochondrial uncoupling by acting as a proton transporter: proton transport uncouples the proton flows via the electron transport chain and ATP synthase to reduce the efficiency of ATP production and cause mitochondrial thermogenesis (By similarity). Proton transporter activity is inhibited by ADP:ATP antiporter activity, suggesting that SLC25A4/ANT1 acts as a master regulator of mitochondrial energy output by maintaining a delicate balance between ATP production (ADP:ATP antiporter activity) and thermogenesis (proton transporter activity) (By similarity). Proton transporter activity requires free fatty acids as cofactor, but does not transport it (By similarity). Also plays a key role in mPTP opening, a non-specific pore that enables free passage of the mitochondrial membranes to solutes of up to 1.5 kDa, and which contributes to cell death . It is however unclear if SLC25A4/ANT1 constitutes a pore-forming component of mPTP or regulates it (By similarity). Acts as a regulator of mitophagy independently of ADP:ATP antiporter activity: promotes mitophagy via interaction with TIMM44, leading to inhibit the presequence translocase TIMM23, thereby promoting stabilization of PINK1 (By similarity). .

FUNCTION: Catalyzes the exchange of ADP and ATP across the membrane. .

FUNCTION: Catalyzes the exchange of ADP and ATP across the membrane. .

FUNCTION: Catalyzes the exchange of ADP and ATP across the membrane. .

FUNCTION: Catalyzes the exchange of ADP and ATP across the membrane. .

AccessionsA0A0S2Z359
P12235
ENST00000491736.1
A0A0S2Z3H3
V9GYG0
A0A0S2Z3C4
ENST00000281456.11