SLC11A2 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0006828Biological processmanganese ion transport
GO_0010039Biological processresponse to iron ion
GO_0048821Biological processerythrocyte development
GO_0006825Biological processcopper ion transport
GO_0007611Biological processlearning or memory
GO_0035434Biological processcopper ion transmembrane transport
GO_0048813Biological processdendrite morphogenesis
GO_1902600Biological processproton transmembrane transport
GO_0034755Biological processiron ion transmembrane transport
GO_0006824Biological processcobalt ion transport
GO_0060586Biological processmulticellular organismal-level iron ion homeostasis
GO_0006783Biological processheme biosynthetic process
GO_0006826Biological processiron ion transport
GO_0071421Biological processmanganese ion transmembrane transport
GO_0006879Biological processintracellular iron ion homeostasis
GO_0033212Biological processiron import into cell
GO_0015692Biological processlead ion transport
GO_0035444Biological processnickel cation transmembrane transport
GO_0070574Biological processcadmium ion transmembrane transport
GO_0031526Cellular componentbrush border membrane
GO_0045178Cellular componentbasal part of cell
GO_0016324Cellular componentapical plasma membrane
GO_0031902Cellular componentlate endosome membrane
GO_0005886Cellular componentplasma membrane
GO_0031410Cellular componentcytoplasmic vesicle
GO_0016020Cellular componentmembrane
GO_0048471Cellular componentperinuclear region of cytoplasm
GO_0005739Cellular componentmitochondrion
GO_0005769Cellular componentearly endosome
GO_0055037Cellular componentrecycling endosome
GO_0005773Cellular componentvacuole
GO_0031901Cellular componentearly endosome membrane
GO_0055038Cellular componentrecycling endosome membrane
GO_1903561Cellular componentextracellular vesicle
GO_0005794Cellular componentGolgi apparatus
GO_0070826Cellular componentparaferritin complex
GO_0005737Cellular componentcytoplasm
GO_0005741Cellular componentmitochondrial outer membrane
GO_0010008Cellular componentendosome membrane
GO_0045177Cellular componentapical part of cell
GO_0005765Cellular componentlysosomal membrane
GO_0005634Cellular componentnucleus
GO_0015093Molecular functionferrous iron transmembrane transporter activity
GO_0015099Molecular functionnickel cation transmembrane transporter activity
GO_0015087Molecular functioncobalt ion transmembrane transporter activity
GO_0015295Molecular functionsolute:proton symporter activity
GO_0005375Molecular functioncopper ion transmembrane transporter activity
GO_0046870Molecular functioncadmium ion binding
GO_0015086Molecular functioncadmium ion transmembrane transporter activity
GO_0005384Molecular functionmanganese ion transmembrane transporter activity
GO_0005381Molecular functioniron ion transmembrane transporter activity
GO_0015094Molecular functionlead ion transmembrane transporter activity
GO_0046915Molecular functiontransition metal ion transmembrane transporter activity
GO_0005515Molecular functionprotein binding

IV. Literature review

[source]
Gene nameSLC11A2
Protein nameSolute carrier family 11 (Proton-coupled divalent metal ion transporters), member 2, isoform CRA_c (cDNA FLJ46799 fis, clone TRACH3031678, highly similar to Natural resistance-associated macrophage protein 2)
Natural resistance-associated macrophage protein 2 (NRAMP 2) (Divalent cation transporter 1) (Divalent metal transporter 1) (DMT-1) (Solute carrier family 11 member 2)
Natural resistance-associated macrophage protein 2 isoform 2 (Solute carrier family 11 (Proton-coupled divalent metal ion transporters), member 2, isoform CRA_b)
Natural resistance-associated macrophage protein 2
Solute carrier family 11 member 2
SynonymsDCT1
hCG_36908
DMT1
NRAMP2
OK/SW-cl.20
DescriptionFUNCTION: Proton-coupled metal ion symporter operating with a proton to metal ion stoichiometry of 1:1 . Selectively transports various divalent metal cations, in decreasing affinity: Cd(2+) > Fe(2+) > Co(2+), Mn(2+) >> Zn(2+), Ni(2+), VO(2+) . Essential for maintenance of iron homeostasis by modulating intestinal absorption of dietary Fe(2+) and TF-associated endosomal Fe(2+) transport in erythroid precursors and other cells (By similarity). Enables Fe(2+) and Mn(2+) ion entry into mitochondria, and is thus expected to promote mitochondrial heme synthesis, iron-sulfur cluster biogenesis and antioxidant defense (By similarity). Can mediate uncoupled fluxes of either protons or metal ions. .

AccessionsENST00000550714.5
A0A2R8Y5L1
F8VRL7
ENST00000642227.1
ENST00000681324.1
ENST00000646988.1
ENST00000547510.5
ENST00000547579.5
A0A0H3W5U4
A0A2R8Y4F9
A0A2R8YDL2
ENST00000646740.1
A0A7P0T8E3
F8W1C0
A0A2R8Y5Q7
B3KY44
P49281
ENST00000262052.9 [P49281-2]
A0A0X8GKR4
ENST00000546488.5
ENST00000549625.1
ENST00000646264.1
A0A0H3W5I8
ENST00000541174.6 [P49281-2]
F8VWB0
ENST00000546743.5
ENST00000547688.7 [P49281-4]
ENST00000551215.5
A0A0A1E835
A0A2R8YD71
ENST00000643884.1
ENST00000546636.5 [P49281-1]
F8W154
F8W1D8
A0A0A1EL53
F8W1P7
ENST00000547732.5
F8W1F2
ENST00000547198.5 [P49281-1]
ENST00000644495.1 [P49281-1]
F8VR36
ENST00000548193.5
H0YIV3
ENST00000545993.7 [P49281-5]
ENST00000394904.9 [P49281-3]