SHTN1 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0007265Biological processRas protein signal transduction
GO_2000114Biological processregulation of establishment of cell polarity
GO_0045773Biological processpositive regulation of axon extension
GO_0061573Biological processactin filament bundle retrograde transport
GO_2001224Biological processpositive regulation of neuron migration
GO_0060327Biological processcytoplasmic actin-based contraction involved in cell motility
GO_0007409Biological processaxonogenesis
GO_0048812Biological processneuron projection morphogenesis
GO_0061163Biological processendoplasmic reticulum polarization
GO_0006930Biological processsubstrate-dependent cell migration, cell extension
GO_0032488Biological processCdc42 protein signal transduction
GO_0038007Biological processnetrin-activated signaling pathway
GO_0005874Cellular componentmicrotubule
GO_0048471Cellular componentperinuclear region of cytoplasm
GO_0043204Cellular componentperikaryon
GO_0031252Cellular componentcell leading edge
GO_0030175Cellular componentfilopodium
GO_0015630Cellular componentmicrotubule cytoskeleton
GO_0030426Cellular componentgrowth cone
GO_0044295Cellular componentaxonal growth cone
GO_0005737Cellular componentcytoplasm
GO_0030424Cellular componentaxon
GO_0030027Cellular componentlamellipodium
GO_0005875Cellular componentmicrotubule associated complex
GO_0045296Molecular functioncadherin binding
GO_0051015Molecular functionactin filament binding
GO_0005515Molecular functionprotein binding
GO_0019894Molecular functionkinesin binding

IV. Literature review

[source]
Gene nameSHTN1
Protein nameShootin-1 (Shootin1)
SynonymsKIAA1598
DescriptionFUNCTION: Involved in the generation of internal asymmetric signals required for neuronal polarization and neurite outgrowth. Mediates netrin-1-induced F-actin-substrate coupling or 'clutch engagement' within the axon growth cone through activation of CDC42, RAC1 and PAK1-dependent signaling pathway, thereby converting the F-actin retrograde flow into traction forces, concomitantly with filopodium extension and axon outgrowth. Plays a role in cytoskeletal organization by regulating the subcellular localization of phosphoinositide 3-kinase (PI3K) activity at the axonal growth cone. Also plays a role in regenerative neurite outgrowth. In the developing cortex, cooperates with KIF20B to promote both the transition from the multipolar to the bipolar stage and the radial migration of cortical neurons from the ventricular zone toward the superficial layer of the neocortex. Involved in the accumulation of phosphatidylinositol 3,4,5-trisphosphate (PIP3) in the growth cone of primary hippocampal neurons. .

AccessionsENST00000392901.10 [A0MZ66-8]
A0MZ66
ENST00000355371.9 [A0MZ66-1]
ENST00000615301.4 [A0MZ66-2]
ENST00000392903.3 [A0MZ66-4]
ENST00000260777.14 [A0MZ66-5]