Name | Number of supported studies | Average coverage | |
---|---|---|---|
macrophage | 24 studies | 29% ± 14% | |
conventional dendritic cell | 18 studies | 26% ± 9% | |
oligodendrocyte | 16 studies | 75% ± 23% | |
microglial cell | 13 studies | 50% ± 19% | |
classical monocyte | 12 studies | 21% ± 7% | |
glutamatergic neuron | 12 studies | 44% ± 22% | |
dendritic cell | 10 studies | 36% ± 15% | |
GABAergic neuron | 10 studies | 55% ± 22% | |
type I pneumocyte | 9 studies | 34% ± 13% | |
astrocyte | 8 studies | 41% ± 12% | |
myeloid cell | 8 studies | 32% ± 15% | |
monocyte | 7 studies | 27% ± 7% | |
epithelial cell | 7 studies | 39% ± 18% | |
neuron | 6 studies | 42% ± 18% | |
retinal ganglion cell | 6 studies | 47% ± 22% | |
ciliated cell | 6 studies | 23% ± 9% | |
type II pneumocyte | 6 studies | 19% ± 2% | |
alveolar macrophage | 5 studies | 31% ± 11% | |
endothelial cell | 5 studies | 31% ± 9% | |
retinal bipolar neuron | 5 studies | 31% ± 7% | |
retinal cone cell | 5 studies | 32% ± 10% | |
retinal rod cell | 5 studies | 21% ± 6% | |
interneuron | 5 studies | 49% ± 20% | |
mononuclear phagocyte | 4 studies | 27% ± 7% | |
retina horizontal cell | 4 studies | 26% ± 8% | |
ON-bipolar cell | 4 studies | 33% ± 6% | |
basal cell | 4 studies | 33% ± 22% | |
plasmacytoid dendritic cell | 4 studies | 22% ± 1% | |
ionocyte | 3 studies | 29% ± 6% | |
non-classical monocyte | 3 studies | 21% ± 4% | |
OFF-bipolar cell | 3 studies | 26% ± 7% | |
rod bipolar cell | 3 studies | 50% ± 5% | |
hepatocyte | 3 studies | 53% ± 18% | |
fibroblast | 3 studies | 19% ± 5% | |
goblet cell | 3 studies | 41% ± 32% | |
granule cell | 3 studies | 34% ± 19% | |
oligodendrocyte precursor cell | 3 studies | 37% ± 11% |
Tissue | GTEx Coverage | GTEx Average TPM | GTEx Number of samples | TCGA Coverage | TCGA Average TPM | TCGA Number of samples |
---|---|---|---|---|---|---|
prostate | 98% | 2287.16 | 241 / 245 | 100% | 27.50 | 500 / 502 |
pancreas | 100% | 3316.88 | 327 / 328 | 97% | 16.66 | 173 / 178 |
brain | 100% | 14409.53 | 2642 / 2642 | 97% | 30.54 | 683 / 705 |
thymus | 100% | 3517.26 | 652 / 653 | 96% | 20.34 | 581 / 605 |
lung | 97% | 2647.27 | 559 / 578 | 99% | 21.20 | 1143 / 1155 |
ovary | 97% | 2197.13 | 175 / 180 | 98% | 14.77 | 423 / 430 |
kidney | 100% | 2381.96 | 89 / 89 | 95% | 17.14 | 852 / 901 |
liver | 100% | 3020.33 | 226 / 226 | 94% | 20.21 | 382 / 406 |
breast | 87% | 1765.86 | 399 / 459 | 100% | 41.29 | 1114 / 1118 |
adrenal gland | 100% | 2710.62 | 258 / 258 | 84% | 9.61 | 194 / 230 |
uterus | 86% | 1275.56 | 147 / 170 | 90% | 16.99 | 414 / 459 |
skin | 87% | 2481.93 | 1571 / 1809 | 88% | 20.32 | 413 / 472 |
stomach | 79% | 1778.65 | 284 / 359 | 95% | 15.88 | 271 / 286 |
intestine | 69% | 1259.46 | 664 / 966 | 95% | 16.66 | 503 / 527 |
esophagus | 64% | 982.10 | 918 / 1445 | 100% | 23.45 | 183 / 183 |
bladder | 48% | 594.14 | 10 / 21 | 72% | 10.61 | 365 / 504 |
tonsil | 0% | 0 | 0 / 0 | 93% | 14.58 | 42 / 45 |
spleen | 84% | 1344.68 | 202 / 241 | 0% | 0 | 0 / 0 |
adipose | 80% | 1243.36 | 963 / 1204 | 0% | 0 | 0 / 0 |
blood vessel | 70% | 1041.80 | 931 / 1335 | 0% | 0 | 0 / 0 |
eye | 0% | 0 | 0 / 0 | 56% | 6.91 | 45 / 80 |
lymph node | 0% | 0 | 0 / 0 | 48% | 5.47 | 14 / 29 |
heart | 26% | 299.28 | 223 / 861 | 0% | 0 | 0 / 0 |
peripheral blood | 14% | 177.47 | 132 / 929 | 0% | 0 | 0 / 0 |
abdomen | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
bone marrow | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
diaphragm | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
gingiva | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
muscle | 0% | 0 | 0 / 803 | 0% | 0 | 0 / 0 |
nasal cavity | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
nasopharynx | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
nose | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
placenta | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
spinal column | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
ureter | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 1 |
GO_0007265 | Biological process | Ras protein signal transduction |
GO_2000114 | Biological process | regulation of establishment of cell polarity |
GO_0045773 | Biological process | positive regulation of axon extension |
GO_0061573 | Biological process | actin filament bundle retrograde transport |
GO_2001224 | Biological process | positive regulation of neuron migration |
GO_0060327 | Biological process | cytoplasmic actin-based contraction involved in cell motility |
GO_0007409 | Biological process | axonogenesis |
GO_0048812 | Biological process | neuron projection morphogenesis |
GO_0061163 | Biological process | endoplasmic reticulum polarization |
GO_0006930 | Biological process | substrate-dependent cell migration, cell extension |
GO_0032488 | Biological process | Cdc42 protein signal transduction |
GO_0038007 | Biological process | netrin-activated signaling pathway |
GO_0005874 | Cellular component | microtubule |
GO_0048471 | Cellular component | perinuclear region of cytoplasm |
GO_0043204 | Cellular component | perikaryon |
GO_0031252 | Cellular component | cell leading edge |
GO_0030175 | Cellular component | filopodium |
GO_0015630 | Cellular component | microtubule cytoskeleton |
GO_0030426 | Cellular component | growth cone |
GO_0044295 | Cellular component | axonal growth cone |
GO_0005737 | Cellular component | cytoplasm |
GO_0030424 | Cellular component | axon |
GO_0030027 | Cellular component | lamellipodium |
GO_0005875 | Cellular component | microtubule associated complex |
GO_0045296 | Molecular function | cadherin binding |
GO_0051015 | Molecular function | actin filament binding |
GO_0005515 | Molecular function | protein binding |
GO_0019894 | Molecular function | kinesin binding |
Gene name | SHTN1 |
Protein name | Shootin-1 (Shootin1) |
Synonyms | KIAA1598 |
Description | FUNCTION: Involved in the generation of internal asymmetric signals required for neuronal polarization and neurite outgrowth. Mediates netrin-1-induced F-actin-substrate coupling or 'clutch engagement' within the axon growth cone through activation of CDC42, RAC1 and PAK1-dependent signaling pathway, thereby converting the F-actin retrograde flow into traction forces, concomitantly with filopodium extension and axon outgrowth. Plays a role in cytoskeletal organization by regulating the subcellular localization of phosphoinositide 3-kinase (PI3K) activity at the axonal growth cone. Also plays a role in regenerative neurite outgrowth. In the developing cortex, cooperates with KIF20B to promote both the transition from the multipolar to the bipolar stage and the radial migration of cortical neurons from the ventricular zone toward the superficial layer of the neocortex. Involved in the accumulation of phosphatidylinositol 3,4,5-trisphosphate (PIP3) in the growth cone of primary hippocampal neurons. . |
Accessions | ENST00000392901.10 [A0MZ66-8] A0MZ66 ENST00000355371.9 [A0MZ66-1] ENST00000615301.4 [A0MZ66-2] ENST00000392903.3 [A0MZ66-4] ENST00000260777.14 [A0MZ66-5] |