SHPRH report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0006974Biological processDNA damage response
GO_0016567Biological processprotein ubiquitination
GO_0006281Biological processDNA repair
GO_0000209Biological processprotein polyubiquitination
GO_0006334Biological processnucleosome assembly
GO_0005654Cellular componentnucleoplasm
GO_0000786Cellular componentnucleosome
GO_0003677Molecular functionDNA binding
GO_0004842Molecular functionubiquitin-protein transferase activity
GO_0061630Molecular functionubiquitin protein ligase activity
GO_0140658Molecular functionATP-dependent chromatin remodeler activity
GO_0004386Molecular functionhelicase activity
GO_0016787Molecular functionhydrolase activity
GO_0031625Molecular functionubiquitin protein ligase binding
GO_0005515Molecular functionprotein binding
GO_0046872Molecular functionmetal ion binding
GO_0005524Molecular functionATP binding

IV. Literature review

[source]
Gene nameSHPRH
Protein nameE3 ubiquitin-protein ligase SHPRH (EC 2.3.2.27) (EC 3.6.4.-) (RING-type E3 ubiquitin transferase SHPRH) (SNF2, histone-linker, PHD and RING finger domain-containing helicase)
SNF2 histone linker PHD RING helicase
SynonymsKIAA2023
hCG_18061
DescriptionFUNCTION: E3 ubiquitin-protein ligase involved in DNA repair. Upon genotoxic stress, accepts ubiquitin from the UBE2N-UBE2V2 E2 complex and transfers it to 'Lys-164' of PCNA which had been monoubiquitinated by UBE2A/B-RAD18, promoting the formation of non-canonical poly-ubiquitin chains linked through 'Lys-63'. .

AccessionsQ5JT88
ENST00000417762.5
H7C2W2
A0A0D9SFM0
ENST00000438092.6 [Q149N8-4]
ENST00000367505.6 [Q149N8-1]
ENST00000521977.1
ENST00000629427.2
ENST00000519632.5 [Q149N8-2]
ENST00000275233.12 [Q149N8-1]
H0YBI0
Q149N8
ENST00000433355.6