SHANK2 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0007584Biological processresponse to nutrient
GO_0007612Biological processlearning
GO_0008344Biological processadult locomotory behavior
GO_0099562Biological processmaintenance of postsynaptic density structure
GO_0008306Biological processassociative learning
GO_0060292Biological processlong-term synaptic depression
GO_0060291Biological processlong-term synaptic potentiation
GO_0071625Biological processvocalization behavior
GO_0030534Biological processadult behavior
GO_0008284Biological processpositive regulation of cell population proliferation
GO_0007416Biological processsynapse assembly
GO_0009410Biological processresponse to xenobiotic stimulus
GO_0035176Biological processsocial behavior
GO_0099175Biological processregulation of postsynapse organization
GO_0035331Biological processnegative regulation of hippo signaling
GO_0031526Cellular componentbrush border membrane
GO_0005575Cellular componentcellular_component
GO_0016324Cellular componentapical plasma membrane
GO_0098978Cellular componentglutamatergic synapse
GO_0005886Cellular componentplasma membrane
GO_0043197Cellular componentdendritic spine
GO_0001750Cellular componentphotoreceptor outer segment
GO_0005883Cellular componentneurofilament
GO_0001917Cellular componentphotoreceptor inner segment
GO_0043025Cellular componentneuronal cell body
GO_0098686Cellular componenthippocampal mossy fiber to CA3 synapse
GO_0043005Cellular componentneuron projection
GO_0060170Cellular componentciliary membrane
GO_0048786Cellular componentpresynaptic active zone
GO_0005829Cellular componentcytosol
GO_0014069Cellular componentpostsynaptic density
GO_0030426Cellular componentgrowth cone
GO_0045211Cellular componentpostsynaptic membrane
GO_0098919Molecular functionstructural constituent of postsynaptic density
GO_0030160Molecular functionsynaptic receptor adaptor activity
GO_0035255Molecular functionionotropic glutamate receptor binding
GO_0005515Molecular functionprotein binding
GO_0017124Molecular functionSH3 domain binding

IV. Literature review

[source]
Gene nameSHANK2
Protein nameSHANK2
SHANK2 protein
SH3 and multiple ankyrin repeat domains 2
Cortactin-binding protein 1 (SH3 and multiple ankyrin repeat domains 2)
Alternative protein SHANK2
SH3 and multiple ankyrin repeat domains protein 2 (Shank2) (Cortactin-binding protein 1) (CortBP1) (Proline-rich synapse-associated protein 1)
SynonymsCORTBP1
KIAA1022
PROSAP1
DescriptionFUNCTION: Seems to be an adapter protein in the postsynaptic density (PSD) of excitatory synapses that interconnects receptors of the postsynaptic membrane including NMDA-type and metabotropic glutamate receptors, and the actin-based cytoskeleton. May play a role in the structural and functional organization of the dendritic spine and synaptic junction.

AccessionsH0Y7S5
I7D9N1
ENST00000426687.2
Q24JS4
ENST00000645599.1
ENST00000338508.9
ENST00000412252.6
E7EUA2
H7BZV1
A0A2R8Y2H5
ENST00000654939.1
A0A590UJF3
A6NHU9
B7ZKU9
ENST00000656230.1 [Q9UPX8-1]
Q9UPX8
ENST00000601538.6 [Q9UPX8-3]
A0A590UJ45
ENST00000409161.5
ENST00000659264.1
I7C337
L8E8F5