SETD3 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0045944Biological processpositive regulation of transcription by RNA polymerase II
GO_0070472Biological processregulation of uterine smooth muscle contraction
GO_0051149Biological processpositive regulation of muscle cell differentiation
GO_0030047Biological processactin modification
GO_0006338Biological processchromatin remodeling
GO_0018026Biological processpeptidyl-lysine monomethylation
GO_0045893Biological processpositive regulation of DNA-templated transcription
GO_0018021Biological processpeptidyl-histidine methylation
GO_0018023Biological processpeptidyl-lysine trimethylation
GO_0005654Cellular componentnucleoplasm
GO_0005737Cellular componentcytoplasm
GO_0000785Cellular componentchromatin
GO_0042800Molecular functionhistone H3K4 methyltransferase activity
GO_0061629Molecular functionRNA polymerase II-specific DNA-binding transcription factor binding
GO_0016279Molecular functionprotein-lysine N-methyltransferase activity
GO_0003713Molecular functiontranscription coactivator activity
GO_0046975Molecular functionhistone H3K36 methyltransferase activity
GO_0005515Molecular functionprotein binding
GO_0003779Molecular functionactin binding
GO_0018064Molecular functionprotein-L-histidine N-tele-methyltransferase activity

IV. Literature review

[source]
Gene nameSETD3
Protein nameSET domain containing 3, actin histidine methyltransferase
protein-histidine N-methyltransferase (EC 2.1.1.85)
Actin-histidine N-methyltransferase (EC 2.1.1.85) (Protein-L-histidine N-tele-methyltransferase) (SET domain-containing protein 3) (hSETD3)
SynonymsC14orf154
DescriptionFUNCTION: Protein-histidine N-methyltransferase that specifically mediates 3-methylhistidine (tele-methylhistidine) methylation of actin at 'His-73' . Histidine methylation of actin is required for smooth muscle contraction of the laboring uterus during delivery . Does not have protein-lysine N-methyltransferase activity and probably only catalyzes histidine methylation of actin . .

AccessionsENST00000329331.7 [Q86TU7-2]
ENST00000331768.10 [Q86TU7-1]
ENST00000630307.2
Q86TU7
C9K0W5
Q6NXR6
ENST00000446066.5
ENST00000357563.4
ENST00000453764.5
ENST00000436070.6