Name | Number of supported studies | Average coverage | |
|---|---|---|---|
| endothelial cell | 14 studies | 28% ± 16% | |
| astrocyte | 9 studies | 29% ± 15% | |
| microglial cell | 8 studies | 27% ± 9% | |
| macrophage | 8 studies | 26% ± 7% | |
| CD16-positive, CD56-dim natural killer cell, human | 7 studies | 18% ± 6% | |
| epithelial cell | 7 studies | 29% ± 9% | |
| natural killer cell | 6 studies | 19% ± 3% | |
| oligodendrocyte | 6 studies | 23% ± 6% | |
| epithelial cell of proximal tubule | 5 studies | 18% ± 3% | |
| retinal rod cell | 5 studies | 27% ± 7% | |
| glutamatergic neuron | 5 studies | 47% ± 22% | |
| myeloid cell | 4 studies | 22% ± 4% | |
| retinal cone cell | 4 studies | 30% ± 8% | |
| dendritic cell | 4 studies | 26% ± 8% | |
| ciliated cell | 4 studies | 26% ± 5% | |
| fibroblast | 4 studies | 21% ± 4% | |
| GABAergic neuron | 4 studies | 43% ± 16% | |
| oligodendrocyte precursor cell | 4 studies | 31% ± 10% | |
| endothelial cell of lymphatic vessel | 4 studies | 28% ± 5% | |
| classical monocyte | 3 studies | 22% ± 3% | |
| hematopoietic precursor cell | 3 studies | 18% ± 1% | |
| non-classical monocyte | 3 studies | 19% ± 5% | |
| lymphocyte | 3 studies | 23% ± 2% | |
| type I pneumocyte | 3 studies | 19% ± 1% | |
| type II pneumocyte | 3 studies | 25% ± 3% | |
| basal cell | 3 studies | 29% ± 6% | |
| goblet cell | 3 studies | 25% ± 10% | |
| transit amplifying cell | 3 studies | 28% ± 13% | |
| interneuron | 3 studies | 42% ± 22% |
Tissue | GTEx Coverage | GTEx Average TPM | GTEx Number of samples | TCGA Coverage | TCGA Average TPM | TCGA Number of samples |
|---|---|---|---|---|---|---|
| breast | 100% | 4180.13 | 459 / 459 | 100% | 49.93 | 1118 / 1118 |
| esophagus | 100% | 4927.59 | 1445 / 1445 | 100% | 32.80 | 183 / 183 |
| kidney | 100% | 5090.22 | 89 / 89 | 100% | 69.69 | 901 / 901 |
| lung | 100% | 4532.78 | 578 / 578 | 100% | 40.19 | 1155 / 1155 |
| stomach | 100% | 3218.42 | 359 / 359 | 100% | 34.00 | 286 / 286 |
| uterus | 100% | 3653.64 | 170 / 170 | 100% | 39.43 | 459 / 459 |
| brain | 100% | 4107.53 | 2641 / 2642 | 100% | 45.15 | 705 / 705 |
| thymus | 100% | 4670.91 | 653 / 653 | 100% | 62.86 | 604 / 605 |
| bladder | 100% | 4965.52 | 21 / 21 | 100% | 38.05 | 503 / 504 |
| ovary | 100% | 2679.28 | 180 / 180 | 100% | 27.45 | 429 / 430 |
| pancreas | 100% | 2037.48 | 327 / 328 | 100% | 43.77 | 178 / 178 |
| intestine | 100% | 5274.47 | 966 / 966 | 100% | 38.26 | 525 / 527 |
| prostate | 100% | 3995.42 | 244 / 245 | 100% | 60.41 | 502 / 502 |
| liver | 100% | 2080.15 | 225 / 226 | 100% | 25.56 | 404 / 406 |
| adrenal gland | 100% | 2825.75 | 258 / 258 | 99% | 40.22 | 227 / 230 |
| skin | 100% | 3661.10 | 1808 / 1809 | 99% | 34.57 | 465 / 472 |
| adipose | 100% | 4487.81 | 1204 / 1204 | 0% | 0 | 0 / 0 |
| blood vessel | 100% | 5046.86 | 1335 / 1335 | 0% | 0 | 0 / 0 |
| lymph node | 0% | 0 | 0 / 0 | 100% | 32.44 | 29 / 29 |
| muscle | 100% | 10200.35 | 803 / 803 | 0% | 0 | 0 / 0 |
| spleen | 100% | 3073.12 | 241 / 241 | 0% | 0 | 0 / 0 |
| tonsil | 0% | 0 | 0 / 0 | 100% | 30.20 | 45 / 45 |
| ureter | 0% | 0 | 0 / 0 | 100% | 29.04 | 1 / 1 |
| heart | 98% | 4499.66 | 841 / 861 | 0% | 0 | 0 / 0 |
| eye | 0% | 0 | 0 / 0 | 96% | 25.47 | 77 / 80 |
| peripheral blood | 90% | 2075.47 | 832 / 929 | 0% | 0 | 0 / 0 |
| abdomen | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| bone marrow | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| diaphragm | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| gingiva | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nasal cavity | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nasopharynx | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nose | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| placenta | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| spinal column | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| GO_0045944 | Biological process | positive regulation of transcription by RNA polymerase II |
| GO_0070472 | Biological process | regulation of uterine smooth muscle contraction |
| GO_0051149 | Biological process | positive regulation of muscle cell differentiation |
| GO_0030047 | Biological process | actin modification |
| GO_0006338 | Biological process | chromatin remodeling |
| GO_0018026 | Biological process | peptidyl-lysine monomethylation |
| GO_0045893 | Biological process | positive regulation of DNA-templated transcription |
| GO_0018021 | Biological process | peptidyl-histidine methylation |
| GO_0018023 | Biological process | peptidyl-lysine trimethylation |
| GO_0005654 | Cellular component | nucleoplasm |
| GO_0005737 | Cellular component | cytoplasm |
| GO_0000785 | Cellular component | chromatin |
| GO_0042800 | Molecular function | histone H3K4 methyltransferase activity |
| GO_0061629 | Molecular function | RNA polymerase II-specific DNA-binding transcription factor binding |
| GO_0016279 | Molecular function | protein-lysine N-methyltransferase activity |
| GO_0003713 | Molecular function | transcription coactivator activity |
| GO_0046975 | Molecular function | histone H3K36 methyltransferase activity |
| GO_0005515 | Molecular function | protein binding |
| GO_0003779 | Molecular function | actin binding |
| GO_0018064 | Molecular function | protein-L-histidine N-tele-methyltransferase activity |
| Gene name | SETD3 |
| Protein name | SET domain containing 3, actin histidine methyltransferase protein-histidine N-methyltransferase (EC 2.1.1.85) Actin-histidine N-methyltransferase (EC 2.1.1.85) (Protein-L-histidine N-tele-methyltransferase) (SET domain-containing protein 3) (hSETD3) |
| Synonyms | C14orf154 |
| Description | FUNCTION: Protein-histidine N-methyltransferase that specifically mediates 3-methylhistidine (tele-methylhistidine) methylation of actin at 'His-73' . Histidine methylation of actin is required for smooth muscle contraction of the laboring uterus during delivery . Does not have protein-lysine N-methyltransferase activity and probably only catalyzes histidine methylation of actin . . |
| Accessions | ENST00000329331.7 [Q86TU7-2] ENST00000331768.10 [Q86TU7-1] ENST00000630307.2 Q86TU7 C9K0W5 Q6NXR6 ENST00000446066.5 ENST00000357563.4 ENST00000453764.5 ENST00000436070.6 |