SESN1 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0042149Biological processcellular response to glucose starvation
GO_0072593Biological processreactive oxygen species metabolic process
GO_0098869Biological processcellular oxidant detoxification
GO_0016239Biological processpositive regulation of macroautophagy
GO_1904262Biological processnegative regulation of TORC1 signaling
GO_0034198Biological processcellular response to amino acid starvation
GO_1990253Biological processcellular response to leucine starvation
GO_1901031Biological processregulation of response to reactive oxygen species
GO_0071233Biological processcellular response to L-leucine
GO_0005654Cellular componentnucleoplasm
GO_0005829Cellular componentcytosol
GO_0061700Cellular componentGATOR2 complex
GO_0005737Cellular componentcytoplasm
GO_0001650Cellular componentfibrillar center
GO_0005634Cellular componentnucleus
GO_0070728Molecular functionL-leucine binding
GO_0005515Molecular functionprotein binding
GO_0016684Molecular functionoxidoreductase activity, acting on peroxide as acceptor

IV. Literature review

[source]
Gene nameSESN1
Protein nameSestrin-1 (EC 1.11.1.-) (p53-regulated protein PA26)
SynonymsSEST1
PA26
DescriptionFUNCTION: Functions as an intracellular leucine sensor that negatively regulates the TORC1 signaling pathway through the GATOR complex. In absence of leucine, binds the GATOR subcomplex GATOR2 and prevents TORC1 signaling. Binding of leucine to SESN2 disrupts its interaction with GATOR2 thereby activating the TORC1 signaling pathway . This stress-inducible metabolic regulator may also play a role in protection against oxidative and genotoxic stresses (By similarity). May positively regulate the transcription by NFE2L2 of genes involved in the response to oxidative stress by facilitating the SQSTM1-mediated autophagic degradation of KEAP1 . Moreover, may prevent the accumulation of reactive oxygen species (ROS) through the alkylhydroperoxide reductase activity born by the N-terminal domain of the protein (By similarity). Was originally reported to contribute to oxidative stress resistance by reducing PRDX1 . However, this could not be confirmed (By similarity). .

AccessionsQ9Y6P5
ENST00000302071.6 [Q9Y6P5-3]
ENST00000356644.7 [Q9Y6P5-1]
ENST00000436639.7 [Q9Y6P5-2]