SENP7 | OmnibusX

I. Expression across cell types

Name	Number of supported studies	Average coverage
endothelial cell	23 studies	32% ± 14%	Explore
oligodendrocyte precursor cell	13 studies	44% ± 20%	Explore
astrocyte	11 studies	42% ± 17%	Explore
microglial cell	11 studies	31% ± 12%	Explore
oligodendrocyte	11 studies	37% ± 14%	Explore
GABAergic neuron	9 studies	52% ± 21%	Explore
glutamatergic neuron	9 studies	43% ± 26%	Explore
fibroblast	9 studies	27% ± 10%	Explore
macrophage	8 studies	36% ± 14%	Explore
pericyte	8 studies	31% ± 14%	Explore
CD4-positive, alpha-beta T cell	7 studies	25% ± 6%	Explore
smooth muscle cell	7 studies	23% ± 5%	Explore
T cell	6 studies	25% ± 9%	Explore
B cell	6 studies	22% ± 6%	Explore
neuron	6 studies	46% ± 18%	Explore
epithelial cell	6 studies	30% ± 14%	Explore
interneuron	6 studies	58% ± 19%	Explore
retina horizontal cell	6 studies	32% ± 15%	Explore
natural killer cell	5 studies	23% ± 4%	Explore
myeloid cell	5 studies	21% ± 4%	Explore
adipocyte	5 studies	22% ± 6%	Explore
mast cell	5 studies	24% ± 5%	Explore
endothelial cell of lymphatic vessel	5 studies	38% ± 7%	Explore
naive thymus-derived CD4-positive, alpha-beta T cell	4 studies	22% ± 4%	Explore
CD16-negative, CD56-bright natural killer cell, human	4 studies	21% ± 3%	Explore
granule cell	4 studies	31% ± 9%	Explore
CD8-positive, alpha-beta T cell	4 studies	22% ± 3%	Explore
cardiac muscle cell	4 studies	19% ± 1%	Explore
ciliated cell	4 studies	25% ± 7%	Explore
lymphocyte	4 studies	38% ± 14%	Explore
amacrine cell	4 studies	30% ± 12%	Explore
type I pneumocyte	4 studies	21% ± 6%	Explore
effector memory CD8-positive, alpha-beta T cell	3 studies	22% ± 2%	Explore
GABAergic interneuron	3 studies	41% ± 10%	Explore
glial cell	3 studies	25% ± 12%	Explore
progenitor cell	3 studies	36% ± 4%	Explore
endothelial cell of artery	3 studies	19% ± 4%	Explore
retinal bipolar neuron	3 studies	29% ± 11%	Explore
OFF-bipolar cell	3 studies	35% ± 12%	Explore
ON-bipolar cell	3 studies	34% ± 11%	Explore
glycinergic amacrine cell	3 studies	30% ± 11%	Explore
retinal rod cell	3 studies	24% ± 1%	Explore
rod bipolar cell	3 studies	27% ± 13%	Explore
dendritic cell	3 studies	19% ± 2%	Explore
neural progenitor cell	3 studies	33% ± 9%	Explore
ependymal cell	3 studies	36% ± 13%	Explore
connective tissue cell	3 studies	20% ± 3%	Explore
myofibroblast cell	3 studies	29% ± 11%	Explore
CD8-positive, alpha-beta memory T cell	3 studies	17% ± 2%	Explore
mural cell	3 studies	39% ± 11%	Explore
regulatory T cell	3 studies	21% ± 3%	Explore

II. Expression across tissues

Name	Number of supported studies	Average coverage
brain	13 studies	42% ± 20%	Explore
lung	4 studies	20% ± 6%	Explore
eye	4 studies	35% ± 11%	Explore
heart	3 studies	20% ± 3%	Explore

Tissue	GTEx Coverage	GTEx Average TPM	GTEx Number of samples	TCGA Coverage	TCGA Average TPM	TCGA Number of samples
brain	100%	1498.68	2629 / 2642	100%	16.50	703 / 705
thymus	100%	2578.91	653 / 653	99%	14.90	600 / 605
prostate	100%	1868.34	245 / 245	99%	10.18	497 / 502
breast	100%	2709.45	459 / 459	99%	12.21	1105 / 1118
ovary	100%	4042.67	180 / 180	99%	7.77	425 / 430
lung	100%	1925.80	576 / 578	99%	9.65	1140 / 1155
kidney	100%	1504.60	89 / 89	98%	11.38	884 / 901
pancreas	99%	1325.26	325 / 328	98%	9.63	175 / 178
adrenal gland	100%	1302.33	258 / 258	97%	8.21	224 / 230
uterus	100%	3691.35	170 / 170	97%	10.10	447 / 459
esophagus	100%	1816.46	1443 / 1445	97%	9.37	177 / 183
bladder	100%	2341.33	21 / 21	96%	7.54	483 / 504
skin	99%	1531.28	1798 / 1809	90%	8.19	426 / 472
stomach	100%	1814.15	359 / 359	90%	5.92	256 / 286
intestine	100%	2208.67	966 / 966	89%	5.15	470 / 527
liver	96%	634.52	216 / 226	84%	4.88	343 / 406
blood vessel	100%	2480.84	1335 / 1335	0%	0	0 / 0
spleen	100%	2550.65	241 / 241	0%	0	0 / 0
tonsil	0%	0	0 / 0	100%	9.51	45 / 45
ureter	0%	0	0 / 0	100%	2.86	1 / 1
adipose	100%	2547.58	1203 / 1204	0%	0	0 / 0
muscle	99%	1115.56	797 / 803	0%	0	0 / 0
heart	99%	1112.91	851 / 861	0%	0	0 / 0
lymph node	0%	0	0 / 0	97%	8.59	28 / 29
peripheral blood	74%	881.95	691 / 929	0%	0	0 / 0
eye	0%	0	0 / 0	59%	3.39	47 / 80
abdomen	0%	0	0 / 0	0%	0	0 / 0
bone marrow	0%	0	0 / 0	0%	0	0 / 0
diaphragm	0%	0	0 / 0	0%	0	0 / 0
gingiva	0%	0	0 / 0	0%	0	0 / 0
nasal cavity	0%	0	0 / 0	0%	0	0 / 0
nasopharynx	0%	0	0 / 0	0%	0	0 / 0
nose	0%	0	0 / 0	0%	0	0 / 0
placenta	0%	0	0 / 0	0%	0	0 / 0
spinal column	0%	0	0 / 0	0%	0	0 / 0

III. Associated gene sets

GO_0016926	Biological process	protein desumoylation
GO_0140374	Biological process	antiviral innate immune response
GO_0006508	Biological process	proteolysis
GO_0005737	Cellular component	cytoplasm
GO_0005634	Cellular component	nucleus
GO_0070139	Molecular function	SUMO-specific endopeptidase activity
GO_0005515	Molecular function	protein binding

IV. Literature review

[source]

Gene name	SENP7
Protein name	Sentrin-specific protease 7 (EC 3.4.22.-) (SUMO-1-specific protease 2) (Sentrin/SUMO-specific protease SENP7) SUMO specific peptidase 7
Synonyms	KIAA1707 SUSP2 SSP2
Description	FUNCTION: Protease that acts as a positive regulator of the cGAS-STING pathway by catalyzing desumoylation of CGAS. Desumoylation of CGAS promotes DNA-binding activity of CGAS, subsequent oligomerization and activation (By similarity). Deconjugates SUMO2 and SUMO3 from targeted proteins, but not SUMO1 . Catalyzes the deconjugation of poly-SUMO2 and poly-SUMO3 chains . Has very low efficiency in processing full-length SUMO proteins to their mature forms . .
Accessions	ENST00000314261.11 [Q9BQF6-5] ENST00000348610.3 [Q9BQF6-2] Q9BQF6 ENST00000394085.7 [Q9BQF6-3] H7C1X8 ENST00000394095.7 [Q9BQF6-1] ENST00000394094.6 J3QT09 ENST00000394091.5 [Q9BQF6-4] ENST00000366089.2

SENP7 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

IV. Literature review