RPTOR report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0071333Biological processcellular response to glucose stimulus
GO_0001558Biological processregulation of cell growth
GO_0030307Biological processpositive regulation of cell growth
GO_1901331Biological processpositive regulation of odontoblast differentiation
GO_0031929Biological processTOR signaling
GO_0033138Biological processpositive regulation of peptidyl-serine phosphorylation
GO_0006974Biological processDNA damage response
GO_0046889Biological processpositive regulation of lipid biosynthetic process
GO_0009267Biological processcellular response to starvation
GO_1900087Biological processpositive regulation of G1/S transition of mitotic cell cycle
GO_0045672Biological processpositive regulation of osteoclast differentiation
GO_0031669Biological processcellular response to nutrient levels
GO_1905857Biological processpositive regulation of pentose-phosphate shunt
GO_0010506Biological processregulation of autophagy
GO_0001938Biological processpositive regulation of endothelial cell proliferation
GO_0045945Biological processpositive regulation of transcription by RNA polymerase III
GO_0071470Biological processcellular response to osmotic stress
GO_0071230Biological processcellular response to amino acid stimulus
GO_0010507Biological processnegative regulation of autophagy
GO_0008361Biological processregulation of cell size
GO_0009410Biological processresponse to xenobiotic stimulus
GO_0010800Biological processpositive regulation of peptidyl-threonine phosphorylation
GO_0035176Biological processsocial behavior
GO_0045821Biological processpositive regulation of glycolytic process
GO_0032008Biological processpositive regulation of TOR signaling
GO_0038202Biological processTORC1 signaling
GO_0071233Biological processcellular response to L-leucine
GO_0071456Biological processcellular response to hypoxia
GO_0005764Cellular componentlysosome
GO_0005654Cellular componentnucleoplasm
GO_0043025Cellular componentneuronal cell body
GO_0030425Cellular componentdendrite
GO_0005829Cellular componentcytosol
GO_0031931Cellular componentTORC1 complex
GO_0005737Cellular componentcytoplasm
GO_0010494Cellular componentcytoplasmic stress granule
GO_0005765Cellular componentlysosomal membrane
GO_0044877Molecular functionprotein-containing complex binding
GO_0140767Molecular functionenzyme-substrate adaptor activity
GO_0030291Molecular functionprotein serine/threonine kinase inhibitor activity
GO_0019901Molecular functionprotein kinase binding
GO_0071889Molecular function14-3-3 protein binding
GO_0031267Molecular functionsmall GTPase binding
GO_0030295Molecular functionprotein kinase activator activity
GO_0030674Molecular functionprotein-macromolecule adaptor activity
GO_0005515Molecular functionprotein binding

IV. Literature review

[source]
Gene nameRPTOR
Protein nameRegulatory-associated protein of mTOR (Raptor) (p150 target of rapamycin (TOR)-scaffold protein)
Regulatory associated protein of MTOR complex 1
SynonymsRAPTOR
KIAA1303
DescriptionFUNCTION: Component of the mechanistic target of rapamycin complex 1 (mTORC1), an evolutionarily conserved central nutrient sensor that stimulates anabolic reactions and macromolecule biosynthesis to promote cellular biomass generation and growth . In response to nutrients, growth factors or amino acids, mTORC1 is recruited to the lysosome membrane and promotes protein, lipid and nucleotide synthesis by phosphorylating several substrates, such as ribosomal protein S6 kinase (RPS6KB1 and RPS6KB2) and EIF4EBP1 (4E-BP1) . In the same time, it inhibits catabolic pathways by phosphorylating the autophagy initiation components ULK1 and ATG13, as well as transcription factor TFEB, a master regulators of lysosomal biogenesis and autophagy . The mTORC1 complex is inhibited in response to starvation and amino acid depletion . Within the mTORC1 complex, RPTOR acts both as a molecular adapter, which (1) mediates recruitment of mTORC1 to lysosomal membranes via interaction with small GTPases Rag (RagA/RRAGA, RagB/RRAGB, RagC/RRAGC and/or RagD/RRAGD), and a (2) substrate-specific adapter, which promotes substrate specificity by binding to TOS motif-containing proteins and direct them towards the active site of the MTOR kinase domain for phosphorylation . mTORC1 complex regulates many cellular processes, such as odontoblast and osteoclast differentiation or neuronal transmission (By similarity). mTORC1 complex in excitatory neuronal transmission is required for the prosocial behavior induced by the psychoactive substance lysergic acid diethylamide (LSD) (By similarity). .

AccessionsENST00000544334.6 [Q8N122-3]
ENST00000570891.5 [Q8N122-2]
ENST00000576366.1
ENST00000697423.1
I3L436
I3L2I3
A0A8V8TMD9
ENST00000574767.5
Q8N122
ENST00000306801.8 [Q8N122-1]