Name | Number of supported studies | Average coverage | |
---|---|---|---|
endothelial cell | 15 studies | 27% ± 12% | |
astrocyte | 12 studies | 35% ± 16% | |
glutamatergic neuron | 10 studies | 48% ± 23% | |
oligodendrocyte precursor cell | 10 studies | 35% ± 15% | |
oligodendrocyte | 10 studies | 33% ± 12% | |
CD16-negative, CD56-bright natural killer cell, human | 9 studies | 18% ± 3% | |
adipocyte | 9 studies | 31% ± 10% | |
GABAergic neuron | 8 studies | 46% ± 19% | |
fibroblast | 8 studies | 22% ± 7% | |
natural killer cell | 7 studies | 19% ± 2% | |
microglial cell | 7 studies | 26% ± 8% | |
neuron | 6 studies | 35% ± 13% | |
amacrine cell | 6 studies | 26% ± 5% | |
epithelial cell | 6 studies | 35% ± 12% | |
interneuron | 6 studies | 50% ± 23% | |
macrophage | 6 studies | 26% ± 7% | |
retina horizontal cell | 6 studies | 21% ± 5% | |
retinal cone cell | 6 studies | 26% ± 6% | |
retinal rod cell | 6 studies | 23% ± 6% | |
endothelial cell of lymphatic vessel | 5 studies | 22% ± 2% | |
CD16-positive, CD56-dim natural killer cell, human | 4 studies | 17% ± 2% | |
CD4-positive, alpha-beta T cell | 4 studies | 16% ± 1% | |
granule cell | 4 studies | 30% ± 8% | |
retinal ganglion cell | 4 studies | 26% ± 7% | |
mast cell | 4 studies | 24% ± 9% | |
retinal bipolar neuron | 4 studies | 18% ± 2% | |
cardiac muscle cell | 4 studies | 22% ± 2% | |
lymphocyte | 4 studies | 26% ± 7% | |
T cell | 4 studies | 18% ± 3% | |
pericyte | 4 studies | 22% ± 5% | |
smooth muscle cell | 4 studies | 22% ± 2% | |
GABAergic interneuron | 3 studies | 35% ± 2% | |
B cell | 3 studies | 29% ± 13% | |
myeloid cell | 3 studies | 19% ± 4% | |
ciliated cell | 3 studies | 20% ± 3% | |
Mueller cell | 3 studies | 19% ± 3% | |
GABAergic amacrine cell | 3 studies | 27% ± 8% | |
OFF-bipolar cell | 3 studies | 21% ± 7% | |
ON-bipolar cell | 3 studies | 20% ± 5% | |
glycinergic amacrine cell | 3 studies | 24% ± 3% | |
hepatocyte | 3 studies | 30% ± 12% | |
dendritic cell | 3 studies | 16% ± 2% | |
myofibroblast cell | 3 studies | 21% ± 5% | |
monocyte | 3 studies | 17% ± 1% | |
type I pneumocyte | 3 studies | 22% ± 5% | |
type II pneumocyte | 3 studies | 19% ± 5% | |
gamma-delta T cell | 3 studies | 20% ± 6% | |
basal cell | 3 studies | 28% ± 14% | |
goblet cell | 3 studies | 28% ± 13% |
Tissue | GTEx Coverage | GTEx Average TPM | GTEx Number of samples | TCGA Coverage | TCGA Average TPM | TCGA Number of samples |
---|---|---|---|---|---|---|
esophagus | 100% | 1252.10 | 1445 / 1445 | 100% | 5.21 | 183 / 183 |
ovary | 100% | 1287.79 | 180 / 180 | 100% | 4.82 | 430 / 430 |
prostate | 100% | 1640.17 | 245 / 245 | 100% | 5.16 | 502 / 502 |
breast | 100% | 1219.29 | 459 / 459 | 100% | 6.63 | 1117 / 1118 |
brain | 100% | 2086.28 | 2637 / 2642 | 100% | 5.01 | 705 / 705 |
uterus | 100% | 1591.56 | 170 / 170 | 99% | 4.70 | 456 / 459 |
thymus | 100% | 1804.47 | 653 / 653 | 99% | 4.44 | 601 / 605 |
lung | 99% | 966.80 | 574 / 578 | 100% | 4.22 | 1154 / 1155 |
bladder | 100% | 1377.43 | 21 / 21 | 99% | 3.90 | 497 / 504 |
pancreas | 100% | 1101.15 | 327 / 328 | 99% | 3.31 | 176 / 178 |
stomach | 100% | 1046.24 | 359 / 359 | 98% | 3.97 | 279 / 286 |
intestine | 100% | 1335.96 | 966 / 966 | 98% | 3.53 | 514 / 527 |
kidney | 100% | 1105.07 | 89 / 89 | 94% | 3.31 | 849 / 901 |
adrenal gland | 100% | 1339.23 | 258 / 258 | 93% | 2.10 | 213 / 230 |
skin | 100% | 1424.82 | 1808 / 1809 | 90% | 3.62 | 427 / 472 |
liver | 100% | 706.70 | 226 / 226 | 87% | 1.96 | 353 / 406 |
adipose | 100% | 1073.37 | 1204 / 1204 | 0% | 0 | 0 / 0 |
lymph node | 0% | 0 | 0 / 0 | 100% | 3.52 | 29 / 29 |
muscle | 100% | 1575.66 | 803 / 803 | 0% | 0 | 0 / 0 |
spleen | 100% | 1242.75 | 241 / 241 | 0% | 0 | 0 / 0 |
tonsil | 0% | 0 | 0 / 0 | 100% | 4.02 | 45 / 45 |
ureter | 0% | 0 | 0 / 0 | 100% | 1.80 | 1 / 1 |
blood vessel | 100% | 1018.64 | 1334 / 1335 | 0% | 0 | 0 / 0 |
heart | 96% | 860.72 | 829 / 861 | 0% | 0 | 0 / 0 |
peripheral blood | 64% | 586.45 | 592 / 929 | 0% | 0 | 0 / 0 |
eye | 0% | 0 | 0 / 0 | 55% | 1.29 | 44 / 80 |
abdomen | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
bone marrow | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
diaphragm | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
gingiva | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
nasal cavity | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
nasopharynx | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
nose | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
placenta | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
spinal column | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
GO_0009301 | Biological process | snRNA transcription |
GO_0036499 | Biological process | PERK-mediated unfolded protein response |
GO_0006357 | Biological process | regulation of transcription by RNA polymerase II |
GO_0097550 | Cellular component | transcription preinitiation complex |
GO_0005730 | Cellular component | nucleolus |
GO_0005654 | Cellular component | nucleoplasm |
GO_0005829 | Cellular component | cytosol |
GO_0005737 | Cellular component | cytoplasm |
GO_0005634 | Cellular component | nucleus |
GO_0008420 | Molecular function | RNA polymerase II CTD heptapeptide repeat phosphatase activity |
GO_0043175 | Molecular function | RNA polymerase core enzyme binding |
GO_0005515 | Molecular function | protein binding |
GO_0017018 | Molecular function | myosin phosphatase activity |
GO_0004722 | Molecular function | protein serine/threonine phosphatase activity |
GO_0046872 | Molecular function | metal ion binding |
Gene name | RPAP2 |
Protein name | Putative RNA polymerase II subunit B1 CTD phosphatase RPAP2 (EC 3.1.3.16) (RNA polymerase II-associated protein 2) |
Synonyms | C1orf82 |
Description | FUNCTION: Protein phosphatase that displays CTD phosphatase activity and regulates transcription of snRNA genes. Recognizes and binds phosphorylated 'Ser-7' of the C-terminal heptapeptide repeat domain (CTD) of the largest RNA polymerase II subunit POLR2A, and mediates dephosphorylation of 'Ser-5' of the CTD, thereby promoting transcription of snRNA genes . Downstream of EIF2AK3/PERK, dephosphorylates ERN1, a sensor for the endoplasmic reticulum unfolded protein response (UPR), to abort failed ER-stress adaptation and trigger apoptosis . . |
Accessions | Q8IXW5 ENST00000610020.2 [Q8IXW5-1] |