Name | Number of supported studies | Average coverage | |
|---|---|---|---|
| endothelial cell | 15 studies | 27% ± 12% | |
| astrocyte | 12 studies | 35% ± 16% | |
| glutamatergic neuron | 10 studies | 48% ± 23% | |
| oligodendrocyte precursor cell | 10 studies | 35% ± 15% | |
| oligodendrocyte | 10 studies | 33% ± 12% | |
| CD16-negative, CD56-bright natural killer cell, human | 9 studies | 18% ± 3% | |
| adipocyte | 9 studies | 31% ± 10% | |
| GABAergic neuron | 8 studies | 46% ± 19% | |
| fibroblast | 8 studies | 22% ± 7% | |
| natural killer cell | 7 studies | 19% ± 2% | |
| microglial cell | 7 studies | 26% ± 8% | |
| neuron | 6 studies | 35% ± 13% | |
| amacrine cell | 6 studies | 26% ± 5% | |
| epithelial cell | 6 studies | 35% ± 12% | |
| interneuron | 6 studies | 50% ± 23% | |
| macrophage | 6 studies | 26% ± 7% | |
| retina horizontal cell | 6 studies | 21% ± 5% | |
| retinal cone cell | 6 studies | 26% ± 6% | |
| retinal rod cell | 6 studies | 23% ± 6% | |
| endothelial cell of lymphatic vessel | 5 studies | 22% ± 2% | |
| CD16-positive, CD56-dim natural killer cell, human | 4 studies | 17% ± 2% | |
| CD4-positive, alpha-beta T cell | 4 studies | 16% ± 1% | |
| granule cell | 4 studies | 30% ± 8% | |
| retinal ganglion cell | 4 studies | 26% ± 7% | |
| mast cell | 4 studies | 24% ± 9% | |
| retinal bipolar neuron | 4 studies | 18% ± 2% | |
| cardiac muscle cell | 4 studies | 22% ± 2% | |
| lymphocyte | 4 studies | 26% ± 7% | |
| T cell | 4 studies | 18% ± 3% | |
| pericyte | 4 studies | 22% ± 5% | |
| smooth muscle cell | 4 studies | 22% ± 2% | |
| GABAergic interneuron | 3 studies | 35% ± 2% | |
| B cell | 3 studies | 29% ± 13% | |
| myeloid cell | 3 studies | 19% ± 4% | |
| ciliated cell | 3 studies | 20% ± 3% | |
| Mueller cell | 3 studies | 19% ± 3% | |
| GABAergic amacrine cell | 3 studies | 27% ± 8% | |
| OFF-bipolar cell | 3 studies | 21% ± 7% | |
| ON-bipolar cell | 3 studies | 20% ± 5% | |
| glycinergic amacrine cell | 3 studies | 24% ± 3% | |
| hepatocyte | 3 studies | 30% ± 12% | |
| dendritic cell | 3 studies | 16% ± 2% | |
| myofibroblast cell | 3 studies | 21% ± 5% | |
| monocyte | 3 studies | 17% ± 1% | |
| type I pneumocyte | 3 studies | 22% ± 5% | |
| type II pneumocyte | 3 studies | 19% ± 5% | |
| gamma-delta T cell | 3 studies | 20% ± 6% | |
| basal cell | 3 studies | 28% ± 14% | |
| goblet cell | 3 studies | 28% ± 13% |
Tissue | GTEx Coverage | GTEx Average TPM | GTEx Number of samples | TCGA Coverage | TCGA Average TPM | TCGA Number of samples |
|---|---|---|---|---|---|---|
| esophagus | 100% | 1252.10 | 1445 / 1445 | 100% | 5.21 | 183 / 183 |
| ovary | 100% | 1287.79 | 180 / 180 | 100% | 4.82 | 430 / 430 |
| prostate | 100% | 1640.17 | 245 / 245 | 100% | 5.16 | 502 / 502 |
| breast | 100% | 1219.29 | 459 / 459 | 100% | 6.63 | 1117 / 1118 |
| brain | 100% | 2086.28 | 2637 / 2642 | 100% | 5.01 | 705 / 705 |
| uterus | 100% | 1591.56 | 170 / 170 | 99% | 4.70 | 456 / 459 |
| thymus | 100% | 1804.47 | 653 / 653 | 99% | 4.44 | 601 / 605 |
| lung | 99% | 966.80 | 574 / 578 | 100% | 4.22 | 1154 / 1155 |
| bladder | 100% | 1377.43 | 21 / 21 | 99% | 3.90 | 497 / 504 |
| pancreas | 100% | 1101.15 | 327 / 328 | 99% | 3.31 | 176 / 178 |
| stomach | 100% | 1046.24 | 359 / 359 | 98% | 3.97 | 279 / 286 |
| intestine | 100% | 1335.96 | 966 / 966 | 98% | 3.53 | 514 / 527 |
| kidney | 100% | 1105.07 | 89 / 89 | 94% | 3.31 | 849 / 901 |
| adrenal gland | 100% | 1339.23 | 258 / 258 | 93% | 2.10 | 213 / 230 |
| skin | 100% | 1424.82 | 1808 / 1809 | 90% | 3.62 | 427 / 472 |
| liver | 100% | 706.70 | 226 / 226 | 87% | 1.96 | 353 / 406 |
| adipose | 100% | 1073.37 | 1204 / 1204 | 0% | 0 | 0 / 0 |
| lymph node | 0% | 0 | 0 / 0 | 100% | 3.52 | 29 / 29 |
| muscle | 100% | 1575.66 | 803 / 803 | 0% | 0 | 0 / 0 |
| spleen | 100% | 1242.75 | 241 / 241 | 0% | 0 | 0 / 0 |
| tonsil | 0% | 0 | 0 / 0 | 100% | 4.02 | 45 / 45 |
| ureter | 0% | 0 | 0 / 0 | 100% | 1.80 | 1 / 1 |
| blood vessel | 100% | 1018.64 | 1334 / 1335 | 0% | 0 | 0 / 0 |
| heart | 96% | 860.72 | 829 / 861 | 0% | 0 | 0 / 0 |
| peripheral blood | 64% | 586.45 | 592 / 929 | 0% | 0 | 0 / 0 |
| eye | 0% | 0 | 0 / 0 | 55% | 1.29 | 44 / 80 |
| abdomen | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| bone marrow | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| diaphragm | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| gingiva | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nasal cavity | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nasopharynx | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nose | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| placenta | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| spinal column | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| GO_0009301 | Biological process | snRNA transcription |
| GO_0036499 | Biological process | PERK-mediated unfolded protein response |
| GO_0006357 | Biological process | regulation of transcription by RNA polymerase II |
| GO_0097550 | Cellular component | transcription preinitiation complex |
| GO_0005730 | Cellular component | nucleolus |
| GO_0005654 | Cellular component | nucleoplasm |
| GO_0005829 | Cellular component | cytosol |
| GO_0005737 | Cellular component | cytoplasm |
| GO_0005634 | Cellular component | nucleus |
| GO_0008420 | Molecular function | RNA polymerase II CTD heptapeptide repeat phosphatase activity |
| GO_0043175 | Molecular function | RNA polymerase core enzyme binding |
| GO_0005515 | Molecular function | protein binding |
| GO_0017018 | Molecular function | myosin phosphatase activity |
| GO_0004722 | Molecular function | protein serine/threonine phosphatase activity |
| GO_0046872 | Molecular function | metal ion binding |
| Gene name | RPAP2 |
| Protein name | Putative RNA polymerase II subunit B1 CTD phosphatase RPAP2 (EC 3.1.3.16) (RNA polymerase II-associated protein 2) |
| Synonyms | C1orf82 |
| Description | FUNCTION: Protein phosphatase that displays CTD phosphatase activity and regulates transcription of snRNA genes. Recognizes and binds phosphorylated 'Ser-7' of the C-terminal heptapeptide repeat domain (CTD) of the largest RNA polymerase II subunit POLR2A, and mediates dephosphorylation of 'Ser-5' of the CTD, thereby promoting transcription of snRNA genes . Downstream of EIF2AK3/PERK, dephosphorylates ERN1, a sensor for the endoplasmic reticulum unfolded protein response (UPR), to abort failed ER-stress adaptation and trigger apoptosis . . |
| Accessions | Q8IXW5 ENST00000610020.2 [Q8IXW5-1] |