RNF166 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0006511Biological processubiquitin-dependent protein catabolic process
GO_0006914Biological processautophagy
GO_0000209Biological processprotein polyubiquitination
GO_0045087Biological processinnate immune response
GO_0005737Cellular componentcytoplasm
GO_0061630Molecular functionubiquitin protein ligase activity
GO_0005515Molecular functionprotein binding
GO_0046872Molecular functionmetal ion binding

IV. Literature review

[source]
Gene nameRNF166
Protein nameRing finger protein 166
RING-type E3 ubiquitin transferase (EC 2.3.2.27)
E3 ubiquitin-protein ligase RNF166 (EC 2.3.2.27) (RING finger protein 166) (RING-type E3 ubiquitin transferase RNF166)
Synonyms
DescriptionFUNCTION: E3 ubiquitin-protein ligase that promotes the ubiquitination of different substrates . In turn, participates in different biological processes including interferon production or autophagy . Plays a role in the activation of RNA virus-induced interferon-beta production by promoting the ubiquitination of TRAF3 and TRAF6 . Also plays a role in the early recruitment of autophagy adapters to bacteria . Mediates 'Lys-29' and 'Lys-33'-linked ubiquitination of SQSTM1 leading to xenophagic targeting of bacteria and inhibition of their replication . .

AccessionsENST00000541206.6 [Q96A37-2]
ENST00000562544.1
ENST00000537718.6 [Q96A37-2]
ENST00000567408.1
ENST00000567844.1 [Q96A37-3]
ENST00000568683.5
ENST00000312838.9 [Q96A37-1]
H3BPZ9
H3BTX7
Q96A37
H3BQ58