RNF113A report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0000398Biological processmRNA splicing, via spliceosome
GO_0016567Biological processprotein ubiquitination
GO_0070100Biological processnegative regulation of chemokine-mediated signaling pathway
GO_0006281Biological processDNA repair
GO_0034247Biological processsnoRNA splicing
GO_0016607Cellular componentnuclear speck
GO_0005654Cellular componentnucleoplasm
GO_0071005Cellular componentU2-type precatalytic spliceosome
GO_0005684Cellular componentU2-type spliceosomal complex
GO_0005634Cellular componentnucleus
GO_0061630Molecular functionubiquitin protein ligase activity
GO_0005515Molecular functionprotein binding
GO_0046872Molecular functionmetal ion binding

IV. Literature review

[source]
Gene nameRNF113A
Protein nameE3 ubiquitin-protein ligase RNF113A (EC 2.3.2.27) (Cwc24 homolog) (RING finger protein 113A) (Zinc finger protein 183)
SynonymsZNF183
RNF113
DescriptionFUNCTION: Required for pre-mRNA splicing as component of the spliceosome . As a component of the minor spliceosome, involved in the splicing of U12-type introns in pre-mRNAs (Probable). E3 ubiquitin-protein ligase that catalyzes the transfer of ubiquitin onto target proteins . Catalyzes polyubiquitination of SNRNP200/BRR2 with non-canonical 'Lys-63'-linked polyubiquitin chains . Plays a role in DNA repair via its role in the synthesis of 'Lys-63'-linked polyubiquitin chains that recruit ALKBH3 and the ASCC complex to sites of DNA damage by alkylating agents . Ubiquitinates CXCR4, leading to its degradation, and thereby contributes to the termination of CXCR4 signaling . .

AccessionsO15541
ENST00000371442.4