RAD51AP1 report

I. Expression across cell types

Insufficient scRNA-seq data for expression of RAD51AP1 at single-cell level.

II. Expression across tissues

sc-RNAseq data

Insufficient scRNA-seq data for expression of RAD51AP1 at tissue level.

III. Associated gene sets

GO_0010569Biological processregulation of double-strand break repair via homologous recombination
GO_0010845Biological processpositive regulation of reciprocal meiotic recombination
GO_0006281Biological processDNA repair
GO_0036297Biological processinterstrand cross-link repair
GO_0006974Biological processDNA damage response
GO_0000724Biological processdouble-strand break repair via homologous recombination
GO_0051321Biological processmeiotic cell cycle
GO_1905168Biological processpositive regulation of double-strand break repair via homologous recombination
GO_0071479Biological processcellular response to ionizing radiation
GO_0032991Cellular componentprotein-containing complex
GO_0005654Cellular componentnucleoplasm
GO_0005694Cellular componentchromosome
GO_0000781Cellular componentchromosome, telomeric region
GO_0000785Cellular componentchromatin
GO_0005634Cellular componentnucleus
GO_0003677Molecular functionDNA binding
GO_0003697Molecular functionsingle-stranded DNA binding
GO_0003690Molecular functiondouble-stranded DNA binding
GO_0000217Molecular functionDNA secondary structure binding
GO_0062037Molecular functionD-loop DNA binding
GO_0003723Molecular functionRNA binding
GO_0005515Molecular functionprotein binding

IV. Literature review

[source]
Gene nameRAD51AP1
Protein nameRAD51 associated protein 1
RAD51-associated protein 1 (HsRAD51AP1) (RAD51-interacting protein)
SynonymsPIR51
DescriptionFUNCTION: Structure-specific DNA-binding protein involved in DNA repair by promoting RAD51-mediated homologous recombination . Acts by stimulating D-Loop formation by RAD51: specifically enhances joint molecule formation through its structure-specific DNA interaction and its interaction with RAD51 . Binds single-stranded DNA (ssDNA), double-stranded DNA (dsDNA) and secondary DNA structures, such as D-loop structures: has a strong preference for branched-DNA structures that are obligatory intermediates during joint molecule formation . Cooperates with WDR48/UAF1 to stimulate RAD51-mediated homologous recombination: both WDR48/UAF1 and RAD51AP1 have coordinated role in DNA-binding during homologous recombination and DNA repair . WDR48/UAF1 and RAD51AP1 also have a coordinated role in DNA-binding to promote USP1-mediated deubiquitination of FANCD2 . Also involved in meiosis by promoting DMC1-mediated homologous meiotic recombination . Key mediator of alternative lengthening of telomeres (ALT) pathway, a homology-directed repair mechanism of telomere elongation that controls proliferation in aggressive cancers, by stimulating homologous recombination . May also bind RNA; additional evidences are however required to confirm RNA-binding in vivo . .

AccessionsENST00000228843.13 [Q96B01-1]
H0YFK6
ENST00000536117.5
F5H031
ENST00000352618.9 [Q96B01-2]
ENST00000538817.5
H0YGT5
F5H710
ENST00000544110.5
Q96B01
ENST00000398012.7
F5H4V6
F5H1Y0
ENST00000536886.5
ENST00000544927.5
ENST00000442992.6
ENST00000535558.5
ENST00000536346.5
ENST00000544173.5