PYHIN1 | OmnibusX

Name	Number of supported studies	Average coverage
natural killer cell	39 studies	41% ± 14%	Explore
CD8-positive, alpha-beta T cell	22 studies	29% ± 10%	Explore
mature NK T cell	19 studies	32% ± 12%	Explore
T cell	17 studies	23% ± 6%	Explore
regulatory T cell	17 studies	23% ± 3%	Explore
CD16-positive, CD56-dim natural killer cell, human	15 studies	46% ± 11%	Explore
mucosal invariant T cell	13 studies	23% ± 7%	Explore
CD16-negative, CD56-bright natural killer cell, human	12 studies	37% ± 14%	Explore
gamma-delta T cell	12 studies	27% ± 6%	Explore
CD8-positive, alpha-beta memory T cell	10 studies	26% ± 8%	Explore
effector memory CD8-positive, alpha-beta T cell	10 studies	29% ± 6%	Explore
CD4-positive, alpha-beta T cell	7 studies	23% ± 7%	Explore
T follicular helper cell	6 studies	19% ± 2%	Explore
effector memory CD8-positive, alpha-beta T cell, terminally differentiated	5 studies	36% ± 11%	Explore
effector CD8-positive, alpha-beta T cell	4 studies	28% ± 5%	Explore
lymphocyte	4 studies	37% ± 8%	Explore
CD4-positive, alpha-beta memory T cell	3 studies	20% ± 2%	Explore
naive thymus-derived CD8-positive, alpha-beta T cell	3 studies	22% ± 9%	Explore
exhausted T cell	3 studies	38% ± 14%	Explore
T-helper 17 cell	3 studies	16% ± 0%	Explore

Name	Number of supported studies	Average coverage
peripheral blood	4 studies	18% ± 1%	Explore

Tissue	GTEx Coverage	GTEx Average TPM	GTEx Number of samples	TCGA Coverage	TCGA Average TPM	TCGA Number of samples
lung	100%	417.29	578 / 578	71%	2.41	822 / 1155
breast	88%	127.75	402 / 459	59%	2.20	659 / 1118
kidney	63%	85.15	56 / 89	64%	2.89	574 / 901
stomach	73%	61.01	261 / 359	53%	1.91	152 / 286
thymus	87%	167.13	569 / 653	39%	1.22	234 / 605
prostate	80%	102.57	197 / 245	29%	0.63	144 / 502
uterus	59%	49.89	101 / 170	47%	1.51	218 / 459
liver	81%	95.34	182 / 226	26%	0.82	106 / 406
bladder	67%	102.67	14 / 21	35%	1.09	177 / 504
intestine	64%	180.92	622 / 966	37%	1.04	196 / 527
spleen	100%	1206.78	241 / 241	0%	0	0 / 0
skin	31%	21.41	553 / 1809	68%	6.20	320 / 472
peripheral blood	97%	1116.11	904 / 929	0%	0	0 / 0
adipose	97%	239.96	1166 / 1204	0%	0	0 / 0
lymph node	0%	0	0 / 0	97%	22.79	28 / 29
esophagus	41%	29.56	596 / 1445	47%	1.34	86 / 183
tonsil	0%	0	0 / 0	80%	3.34	36 / 45
pancreas	9%	4.85	28 / 328	53%	1.78	94 / 178
ovary	27%	18.24	49 / 180	29%	0.59	123 / 430
blood vessel	55%	60.59	730 / 1335	0%	0	0 / 0
heart	34%	24.23	290 / 861	0%	0	0 / 0
adrenal gland	25%	15.49	65 / 258	6%	0.12	13 / 230
eye	0%	0	0 / 0	23%	1.04	18 / 80
muscle	9%	5.19	74 / 803	0%	0	0 / 0
brain	5%	2.88	133 / 2642	3%	0.07	19 / 705
abdomen	0%	0	0 / 0	0%	0	0 / 0
bone marrow	0%	0	0 / 0	0%	0	0 / 0
diaphragm	0%	0	0 / 0	0%	0	0 / 0
gingiva	0%	0	0 / 0	0%	0	0 / 0
nasal cavity	0%	0	0 / 0	0%	0	0 / 0
nasopharynx	0%	0	0 / 0	0%	0	0 / 0
nose	0%	0	0 / 0	0%	0	0 / 0
placenta	0%	0	0 / 0	0%	0	0 / 0
spinal column	0%	0	0 / 0	0%	0	0 / 0
ureter	0%	0	0 / 0	0%	0	0 / 1

GO_0035457	Biological process	cellular response to interferon-alpha
GO_2000060	Biological process	positive regulation of ubiquitin-dependent protein catabolic process
GO_1902164	Biological process	positive regulation of DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator
GO_0045893	Biological process	positive regulation of DNA-templated transcription
GO_0050821	Biological process	protein stabilization
GO_0031648	Biological process	protein destabilization
GO_0035458	Biological process	cellular response to interferon-beta
GO_1900182	Biological process	positive regulation of protein localization to nucleus
GO_0043388	Biological process	positive regulation of DNA binding
GO_0002218	Biological process	activation of innate immune response
GO_0016607	Cellular component	nuclear speck
GO_0005730	Cellular component	nucleolus
GO_0032991	Cellular component	protein-containing complex
GO_0005654	Cellular component	nucleoplasm
GO_0005829	Cellular component	cytosol
GO_0003690	Molecular function	double-stranded DNA binding
GO_0031625	Molecular function	ubiquitin protein ligase binding

Gene name	PYHIN1
Protein name	Pyrin and HIN domain family member 1 Pyrin and HIN domain-containing protein 1 (Interferon-inducible protein X)
Synonyms	IFIX
Description	FUNCTION: Major mediator of the tumor suppressor activity of IFN in breast cancer cells. Promotes ubiquitination and subsequent degradation of MDM2, which leads to p53/TP53 stabilization. Promotes ubiquitination and subsequent degradation of HDAC1, which in turn enhances maspin expression, and impairs invasive activity of cancer cells. .
Accessions	Q6K0P9 ENST00000392252.7 [Q6K0P9-4] ENST00000368140.6 [Q6K0P9-1] ENST00000368138.7 [Q6K0P9-2] ENST00000458222.5 ENST00000368135.4 [Q6K0P9-5] X6RHR0 ENST00000392254.6 [Q6K0P9-3]

PYHIN1 report