PSMD3 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0006511Biological processubiquitin-dependent protein catabolic process
GO_0042176Biological processregulation of protein catabolic process
GO_0043161Biological processproteasome-mediated ubiquitin-dependent protein catabolic process
GO_0000502Cellular componentproteasome complex
GO_1904813Cellular componentficolin-1-rich granule lumen
GO_0070062Cellular componentextracellular exosome
GO_0005654Cellular componentnucleoplasm
GO_0005829Cellular componentcytosol
GO_0005576Cellular componentextracellular region
GO_0008541Cellular componentproteasome regulatory particle, lid subcomplex
GO_0022624Cellular componentproteasome accessory complex
GO_0016020Cellular componentmembrane
GO_0034774Cellular componentsecretory granule lumen
GO_0005634Cellular componentnucleus
GO_0030234Molecular functionenzyme regulator activity
GO_0005515Molecular functionprotein binding

IV. Literature review

[source]
Gene namePSMD3
Protein namePSMD3 protein
Proteasome 26S subunit, non-ATPase 3
26S proteasome non-ATPase regulatory subunit 3 (26S proteasome regulatory subunit RPN3) (26S proteasome regulatory subunit S3) (Proteasome subunit p58)
Synonyms
DescriptionFUNCTION: Component of the 26S proteasome, a multiprotein complex involved in the ATP-dependent degradation of ubiquitinated proteins. This complex plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins, which could impair cellular functions, and by removing proteins whose functions are no longer required. Therefore, the proteasome participates in numerous cellular processes, including cell cycle progression, apoptosis, or DNA damage repair. .

AccessionsENST00000540504.2
Q6IBN0
O43242
F5H8K4
ENST00000264639.9 [O43242-1]
ENST00000415039.7
H0YGV8