PPIE report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0045070Biological processpositive regulation of viral genome replication
GO_0000398Biological processmRNA splicing, via spliceosome
GO_0006457Biological processprotein folding
GO_0006355Biological processregulation of DNA-templated transcription
GO_0000413Biological processprotein peptidyl-prolyl isomerization
GO_0005576Cellular componentextracellular region
GO_0016607Cellular componentnuclear speck
GO_0005654Cellular componentnucleoplasm
GO_0071007Cellular componentU2-type catalytic step 2 spliceosome
GO_0034774Cellular componentsecretory granule lumen
GO_1904813Cellular componentficolin-1-rich granule lumen
GO_0005829Cellular componentcytosol
GO_0005737Cellular componentcytoplasm
GO_0043231Cellular componentintracellular membrane-bounded organelle
GO_0071013Cellular componentcatalytic step 2 spliceosome
GO_0005634Cellular componentnucleus
GO_0008143Molecular functionpoly(A) binding
GO_0003755Molecular functionpeptidyl-prolyl cis-trans isomerase activity
GO_0003729Molecular functionmRNA binding
GO_0003723Molecular functionRNA binding
GO_0005515Molecular functionprotein binding
GO_0016018Molecular functioncyclosporin A binding

IV. Literature review

[source]
Gene namePPIE
Protein namePeptidyl-prolyl cis-trans isomerase (PPIase) (EC 5.2.1.8)
Peptidyl-prolyl cis-trans isomerase E (PPIase E) (EC 5.2.1.8) (Cyclophilin E) (Cyclophilin-33) (Rotamase E)
Peptidylprolyl isomerase E
SynonymsCYP33
DescriptionFUNCTION: Involved in pre-mRNA splicing as component of the spliceosome . Combines RNA-binding and PPIase activities . Binds mRNA and has a preference for single-stranded RNA molecules with poly-A and poly-U stretches, suggesting it binds to the poly(A)-region in the 3'-UTR of mRNA molecules . Catalyzes the cis-trans isomerization of proline imidic peptide bonds in proteins . Inhibits KMT2A activity; this requires proline isomerase activity . .

FUNCTION: PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides. .

FUNCTION: PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides. .

AccessionsE9PK21
H0YE31
ENST00000372835.9
ENST00000470213.5
ENST00000497370.5
E9PEQ6
E9PIB0
H0YCV4
E9PMH0
ENST00000474804.5
ENST00000470018.5
ENST00000324379.10 [Q9UNP9-1]
ENST00000495526.5
ENST00000475350.5
ENST00000356511.6 [Q9UNP9-2]
ENST00000372830.5 [Q9UNP9-3]
E9PKY5
Q9UNP9