PPARGC1A report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0097009Biological processenergy homeostasis
GO_0050873Biological processbrown fat cell differentiation
GO_0006397Biological processmRNA processing
GO_0051091Biological processpositive regulation of DNA-binding transcription factor activity
GO_0019395Biological processfatty acid oxidation
GO_0007586Biological processdigestion
GO_0010628Biological processpositive regulation of gene expression
GO_0045333Biological processcellular respiration
GO_0046321Biological processpositive regulation of fatty acid oxidation
GO_0002021Biological processresponse to dietary excess
GO_0001678Biological processintracellular glucose homeostasis
GO_0032922Biological processcircadian regulation of gene expression
GO_0042752Biological processregulation of circadian rhythm
GO_0065003Biological processprotein-containing complex assembly
GO_0042594Biological processresponse to starvation
GO_0014850Biological processresponse to muscle activity
GO_0051402Biological processneuron apoptotic process
GO_0045722Biological processpositive regulation of gluconeogenesis
GO_0034599Biological processcellular response to oxidative stress
GO_0007005Biological processmitochondrion organization
GO_0008380Biological processRNA splicing
GO_0045893Biological processpositive regulation of DNA-templated transcription
GO_0050821Biological processprotein stabilization
GO_0006094Biological processgluconeogenesis
GO_0022904Biological processrespiratory electron transport chain
GO_0048662Biological processnegative regulation of smooth muscle cell proliferation
GO_0006355Biological processregulation of DNA-templated transcription
GO_0120162Biological processpositive regulation of cold-induced thermogenesis
GO_0060612Biological processadipose tissue development
GO_0001659Biological processtemperature homeostasis
GO_0006367Biological processtranscription initiation at RNA polymerase II promoter
GO_0043524Biological processnegative regulation of neuron apoptotic process
GO_0045944Biological processpositive regulation of transcription by RNA polymerase II
GO_0005654Cellular componentnucleoplasm
GO_0005829Cellular componentcytosol
GO_0016605Cellular componentPML body
GO_0000785Cellular componentchromatin
GO_0005634Cellular componentnucleus
GO_0008134Molecular functiontranscription factor binding
GO_0003677Molecular functionDNA binding
GO_0016922Molecular functionnuclear receptor binding
GO_0140297Molecular functionDNA-binding transcription factor binding
GO_0043565Molecular functionsequence-specific DNA binding
GO_0031625Molecular functionubiquitin protein ligase binding
GO_0003712Molecular functiontranscription coregulator activity
GO_0061629Molecular functionRNA polymerase II-specific DNA-binding transcription factor binding
GO_0106222Molecular functionlncRNA binding
GO_0003723Molecular functionRNA binding
GO_0031490Molecular functionchromatin DNA binding
GO_0003713Molecular functiontranscription coactivator activity
GO_0030374Molecular functionnuclear receptor coactivator activity
GO_0005515Molecular functionprotein binding

IV. Literature review

[source]
Gene namePPARGC1A
Protein namePeroxisome proliferator-activated receptor gamma coactivator 1-alpha (PGC-1-alpha) (PPAR-gamma coactivator 1-alpha) (PPARGC-1-alpha) (Ligand effect modulator 6)
PPARG coactivator 1 alpha
SynonymsPGC1
LEM6
PPARGC1
PGC1A
DescriptionFUNCTION: Transcriptional coactivator for steroid receptors and nuclear receptors . Greatly increases the transcriptional activity of PPARG and thyroid hormone receptor on the uncoupling protein promoter . Can regulate key mitochondrial genes that contribute to the program of adaptive thermogenesis . Plays an essential role in metabolic reprogramming in response to dietary availability through coordination of the expression of a wide array of genes involved in glucose and fatty acid metabolism . Acts as a key regulator of gluconeogenesis: stimulates hepatic gluconeogenesis by increasing the expression of gluconeogenic enzymes, and acting together with FOXO1 to promote the fasting gluconeogenic program . Induces the expression of PERM1 in the skeletal muscle in an ESRRA-dependent manner . Also involved in the integration of the circadian rhythms and energy metabolism (By similarity). Required for oscillatory expression of clock genes, such as BMAL1 and NR1D1, through the coactivation of RORA and RORC, and metabolic genes, such as PDK4 and PEPCK (By similarity). .

AccessionsENST00000617484.4
ENST00000507380.1
A0A087WVW3
ENST00000612355.1
ENST00000513205.5 [Q9UBK2-8]
D6RBF3
A0A087WTJ3
ENST00000264867.7 [Q9UBK2-1]
ENST00000613098.4 [Q9UBK2-9]
Q9UBK2
ENST00000506055.5 [Q9UBK2-2]