PNPLA8 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0070328Biological processtriglyceride homeostasis
GO_0043651Biological processlinoleic acid metabolic process
GO_0006631Biological processfatty acid metabolic process
GO_0034638Biological processphosphatidylcholine catabolic process
GO_0035556Biological processintracellular signal transduction
GO_0046338Biological processphosphatidylethanolamine catabolic process
GO_0001516Biological processprostaglandin biosynthetic process
GO_0032048Biological processcardiolipin metabolic process
GO_1900407Biological processregulation of cellular response to oxidative stress
GO_0055088Biological processlipid homeostasis
GO_0019369Biological processarachidonic acid metabolic process
GO_0050482Biological processarachidonic acid secretion
GO_0005778Cellular componentperoxisomal membrane
GO_0016020Cellular componentmembrane
GO_0005789Cellular componentendoplasmic reticulum membrane
GO_0005739Cellular componentmitochondrion
GO_0031966Cellular componentmitochondrial membrane
GO_0005777Cellular componentperoxisome
GO_0008970Molecular functionphospholipase A1 activity
GO_0047499Molecular functioncalcium-independent phospholipase A2 activity
GO_0004622Molecular functionlysophospholipase activity
GO_0102545Molecular functionphosphatidyl phospholipase B activity
GO_0005524Molecular functionATP binding

IV. Literature review

[source]
Gene namePNPLA8
Protein nameCalcium-independent phospholipase A2-gamma (EC 3.1.1.-) (EC 3.1.1.5) (Intracellular membrane-associated calcium-independent phospholipase A2 gamma) (iPLA2-gamma) (PNPLA-gamma) (Patatin-like phospholipase domain-containing protein 8) (iPLA2-2)
Patatin like phospholipase domain containing 8
SynonymsBM-043
IPLA22
IPLA2G
DescriptionFUNCTION: Calcium-independent and membrane-bound phospholipase, that catalyzes the esterolytic cleavage of fatty acids from glycerophospholipids to yield free fatty acids and lysophospholipids, hence regulating membrane physical properties and the release of lipid second messengers and growth factors . Hydrolyzes phosphatidylethanolamine, phosphatidylcholine and probably phosphatidylinositol with a possible preference for the former . Has also a broad substrate specificity in terms of fatty acid moieties, hydrolyzing saturated and mono-unsaturated fatty acids at nearly equal rates from either the sn-1 or sn-2 position in diacyl phosphatidylcholine . However, has a weak activity toward polyunsaturated fatty acids at the sn-2 position, and thereby favors the production of 2-arachidonoyl lysophosphatidylcholine, a key branch point metabolite in eicosanoid signaling . On the other hand, can produce arachidonic acid from the sn-1 position of diacyl phospholipid and from the sn-2 position of arachidonate-containing plasmalogen substrates . Therefore, plays an important role in the mobilization of arachidonic acid in response to cellular stimuli and the generation of lipid second messengers . Can also hydrolyze lysophosphatidylcholine . In the mitochondrial compartment, catalyzes the hydrolysis and release of oxidized aliphatic chains from cardiolipin and integrates mitochondrial bioenergetics and signaling. It is essential for maintaining efficient bioenergetic mitochondrial function through tailoring mitochondrial membrane lipid metabolism and composition . .

AccessionsENST00000426128.6 [Q9NP80-2]
C9JAX4
ENST00000453085.1
ENST00000257694.13 [Q9NP80-1]
A0A0C4DG51
ENST00000415498.2
Q9NP80
ENST00000436062.5 [Q9NP80-1]
ENST00000453144.5 [Q9NP80-3]
ENST00000427008.1
ENST00000422087.5 [Q9NP80-1]
C9J9W9