PFN2 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0030837Biological processnegative regulation of actin filament polymerization
GO_0030838Biological processpositive regulation of actin filament polymerization
GO_0032781Biological processpositive regulation of ATP-dependent activity
GO_0030833Biological processregulation of actin filament polymerization
GO_0051496Biological processpositive regulation of stress fiber assembly
GO_0033138Biological processpositive regulation of peptidyl-serine phosphorylation
GO_0032233Biological processpositive regulation of actin filament bundle assembly
GO_0030036Biological processactin cytoskeleton organization
GO_0098885Biological processmodification of postsynaptic actin cytoskeleton
GO_0050821Biological processprotein stabilization
GO_0099171Biological processpresynaptic modulation of chemical synaptic transmission
GO_0010633Biological processnegative regulation of epithelial cell migration
GO_1900028Biological processnegative regulation of ruffle assembly
GO_2000300Biological processregulation of synaptic vesicle exocytosis
GO_0098978Cellular componentglutamatergic synapse
GO_0098793Cellular componentpresynapse
GO_0005856Cellular componentcytoskeleton
GO_0098685Cellular componentSchaffer collateral - CA1 synapse
GO_0070062Cellular componentextracellular exosome
GO_0098794Cellular componentpostsynapse
GO_0005737Cellular componentcytoplasm
GO_0003785Molecular functionactin monomer binding
GO_0005546Molecular functionphosphatidylinositol-4,5-bisphosphate binding
GO_0005515Molecular functionprotein binding
GO_0003779Molecular functionactin binding
GO_0016887Molecular functionATP hydrolysis activity

IV. Literature review

[source]
Gene namePFN2
Protein nameProfilin
Profilin-2 (Profilin II)
Profilin 2
SynonymshCG_21343
DescriptionFUNCTION: Binds to actin and affects the structure of the cytoskeleton. At high concentrations, profilin prevents the polymerization of actin, whereas it enhances it at low concentrations. By binding to PIP2, it inhibits the formation of IP3 and DG.

AccessionsENST00000475518.5
C9J5V8
C9J0J7
P35080
ENST00000461930.1
ENST00000649949.1
ENST00000498169.1
ENST00000461868.1
ENST00000490975.1
ENST00000239940.12 [P35080-1]
ENST00000494827.5
F2Z3G0
ENST00000498307.5
C9J712
G5E9Q6
ENST00000460404.5
ENST00000423691.2
C9J2N0
ENST00000497148.5
ENST00000481767.5
ENST00000489155.1
ENST00000481275.5
ENST00000468323.5
ENST00000452853.6 [P35080-2]
C9JQ45