PEF1 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_1902527Biological processpositive regulation of protein monoubiquitination
GO_0014032Biological processneural crest cell development
GO_0014029Biological processneural crest formation
GO_0006888Biological processendoplasmic reticulum to Golgi vesicle-mediated transport
GO_0051592Biological processresponse to calcium ion
GO_0048208Biological processCOPII vesicle coating
GO_0070062Cellular componentextracellular exosome
GO_0031463Cellular componentCul3-RING ubiquitin ligase complex
GO_0030127Cellular componentCOPII vesicle coat
GO_0005783Cellular componentendoplasmic reticulum
GO_0005737Cellular componentcytoplasm
GO_1990756Molecular functionubiquitin-like ligase-substrate adaptor activity
GO_0042802Molecular functionidentical protein binding
GO_0048306Molecular functioncalcium-dependent protein binding
GO_0003723Molecular functionRNA binding
GO_0046982Molecular functionprotein heterodimerization activity
GO_0005509Molecular functioncalcium ion binding
GO_0046983Molecular functionprotein dimerization activity
GO_0005515Molecular functionprotein binding

IV. Literature review

[source]
Gene namePEF1
Protein namePeflin (PEF protein with a long N-terminal hydrophobic domain) (Penta-EF hand domain-containing protein 1)
SynonymsUNQ1845/PRO3573
hCG_1811710
ABP32
DescriptionFUNCTION: Calcium-binding protein that acts as an adapter that bridges unrelated proteins or stabilizes weak protein-protein complexes in response to calcium. Together with PDCD6, acts as a calcium-dependent adapter for the BCR(KLHL12) complex, a complex involved in endoplasmic reticulum (ER)-Golgi transport by regulating the size of COPII coats . In response to cytosolic calcium increase, the heterodimer formed with PDCD6 interacts with, and bridges together the BCR(KLHL12) complex and SEC31 (SEC31A or SEC31B), promoting monoubiquitination of SEC31 and subsequent collagen export, which is required for neural crest specification . Its role in the heterodimer formed with PDCD6 is however unclear: some evidence shows that PEF1 and PDCD6 work together and promote association between PDCD6 and SEC31 in presence of calcium . Other reports show that PEF1 dissociates from PDCD6 in presence of calcium, and may act as a negative regulator of PDCD6 . Also acts as a negative regulator of ER-Golgi transport; possibly by inhibiting interaction between PDCD6 and SEC31 (By similarity). .

AccessionsENST00000373703.5
A0A384MQX5
Q9UBV8