PDZD8 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0022604Biological processregulation of cell morphogenesis
GO_0051560Biological processmitochondrial calcium ion homeostasis
GO_0007010Biological processcytoskeleton organization
GO_0006869Biological processlipid transport
GO_1990456Biological processmitochondrion-endoplasmic reticulum membrane tethering
GO_0044233Cellular componentmitochondria-associated endoplasmic reticulum membrane contact site
GO_0016020Cellular componentmembrane
GO_0005789Cellular componentendoplasmic reticulum membrane
GO_0005739Cellular componentmitochondrion
GO_0005515Molecular functionprotein binding
GO_0008289Molecular functionlipid binding
GO_0046872Molecular functionmetal ion binding

IV. Literature review

[source]
Gene namePDZD8
Protein namePDZ domain-containing protein 8 (Sarcoma antigen NY-SAR-84/NY-SAR-104)
SynonymsPDZK8
DescriptionFUNCTION: Molecular tethering protein that connects endoplasmic reticulum and mitochondria membranes . PDZD8-dependent endoplasmic reticulum-mitochondria membrane tethering is essential for endoplasmic reticulum-mitochondria Ca(2+) transfer . In neurons, involved in the regulation of dendritic Ca(2+) dynamics by regulating mitochondrial Ca(2+) uptake in neurons . Plays an indirect role in the regulation of cell morphology and cytoskeletal organization . May inhibit herpes simplex virus 1 infection at an early stage . .

AccessionsENST00000334464.7
Q8NEN9