PDSS2 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0021549Biological processcerebellum development
GO_0008299Biological processisoprenoid biosynthetic process
GO_0050878Biological processregulation of body fluid levels
GO_0006744Biological processubiquinone biosynthetic process
GO_0032478Cellular componentheterotetrameric polyprenyl diphosphate synthase complex
GO_0005829Cellular componentcytosol
GO_0005759Cellular componentmitochondrial matrix
GO_1990234Cellular componenttransferase complex
GO_0046982Molecular functionprotein heterodimerization activity
GO_0052923Molecular functionall-trans-nonaprenyl-diphosphate synthase (geranyl-diphosphate specific) activity
GO_0005515Molecular functionprotein binding
GO_0004659Molecular functionprenyltransferase activity
GO_0097269Molecular functionall-trans-decaprenyl-diphosphate synthase activity

IV. Literature review

[source]
Gene namePDSS2
Protein nameDecaprenyl diphosphate synthase subunit 2
All trans-polyprenyl-diphosphate synthase PDSS2 (All-trans-decaprenyl-diphosphate synthase subunit 2) (EC 2.5.1.91) (Candidate tumor suppressor protein) (Decaprenyl pyrophosphate synthase subunit 2) (Decaprenyl-diphosphate synthase subunit 2) (Solanesyl-diphosphate synthase subunit 2)
SynonymsDLP1
C6orf210
DescriptionFUNCTION: Heterotetrameric enzyme that catalyzes the condensation of farnesyl diphosphate (FPP), which acts as a primer, and isopentenyl diphosphate (IPP) to produce prenyl diphosphates of varying chain lengths and participates in the determination of the side chain of ubiquinone . Supplies nona and decaprenyl diphosphate, the precursors for the side chain of the isoprenoid quinones ubiquinone-9 (Q9) and ubiquinone-10 (Q10) respectively . The enzyme adds isopentenyl diphosphate molecules sequentially to farnesyl diphosphate with trans stereochemistry . May play a role during cerebellar development (By similarity). May regulate mitochondrial respiratory chain function (By similarity). .

AccessionsQ5JRD6
Q86YH6
ENST00000369031.4 [Q86YH6-2]
ENST00000369037.9 [Q86YH6-1]
ENST00000449027.1