Name | Number of supported studies | Average coverage | |
---|---|---|---|
macrophage | 33 studies | 36% ± 18% | |
endothelial cell | 30 studies | 34% ± 16% | |
fibroblast | 28 studies | 31% ± 15% | |
pericyte | 23 studies | 39% ± 15% | |
smooth muscle cell | 22 studies | 44% ± 17% | |
endothelial cell of vascular tree | 11 studies | 33% ± 15% | |
adipocyte | 9 studies | 47% ± 21% | |
alveolar macrophage | 8 studies | 31% ± 6% | |
monocyte | 8 studies | 26% ± 5% | |
endothelial cell of lymphatic vessel | 8 studies | 25% ± 10% | |
endothelial cell of artery | 8 studies | 32% ± 9% | |
kidney loop of Henle epithelial cell | 8 studies | 35% ± 13% | |
astrocyte | 8 studies | 30% ± 9% | |
myofibroblast cell | 8 studies | 35% ± 12% | |
non-classical monocyte | 8 studies | 21% ± 5% | |
vein endothelial cell | 8 studies | 29% ± 9% | |
ciliated cell | 8 studies | 37% ± 20% | |
capillary endothelial cell | 7 studies | 34% ± 10% | |
oligodendrocyte | 7 studies | 25% ± 10% | |
myeloid cell | 7 studies | 40% ± 16% | |
connective tissue cell | 6 studies | 36% ± 17% | |
epithelial cell of proximal tubule | 6 studies | 34% ± 12% | |
microglial cell | 6 studies | 24% ± 4% | |
epithelial cell | 6 studies | 42% ± 23% | |
cardiac muscle cell | 6 studies | 56% ± 19% | |
renal principal cell | 5 studies | 41% ± 22% | |
enterocyte | 5 studies | 37% ± 17% | |
glial cell | 5 studies | 32% ± 16% | |
adventitial cell | 5 studies | 29% ± 5% | |
pancreatic A cell | 4 studies | 48% ± 13% | |
mononuclear phagocyte | 4 studies | 27% ± 13% | |
endothelial cell of sinusoid | 4 studies | 38% ± 20% | |
glomerular endothelial cell | 4 studies | 60% ± 12% | |
conventional dendritic cell | 4 studies | 21% ± 6% | |
hepatocyte | 4 studies | 39% ± 30% | |
dendritic cell | 3 studies | 34% ± 11% | |
hepatic stellate cell | 3 studies | 25% ± 4% | |
endocardial cell | 3 studies | 35% ± 12% | |
lymphocyte | 3 studies | 27% ± 9% | |
muscle cell | 3 studies | 54% ± 16% | |
Schwann cell | 3 studies | 40% ± 19% | |
luminal hormone-sensing cell of mammary gland | 3 studies | 33% ± 14% | |
podocyte | 3 studies | 43% ± 11% |
Name | Number of supported studies | Average coverage | |
---|---|---|---|
kidney | 7 studies | 27% ± 12% | |
brain | 7 studies | 21% ± 4% | |
heart | 5 studies | 36% ± 14% | |
adipose | 5 studies | 37% ± 20% | |
uterus | 4 studies | 21% ± 6% | |
liver | 4 studies | 23% ± 9% | |
lung | 3 studies | 22% ± 5% | |
pancreas | 3 studies | 31% ± 7% | |
intestine | 3 studies | 32% ± 17% | |
breast | 3 studies | 18% ± 2% |
Tissue | GTEx Coverage | GTEx Average TPM | GTEx Number of samples | TCGA Coverage | TCGA Average TPM | TCGA Number of samples |
---|---|---|---|---|---|---|
adrenal gland | 98% | 33988.20 | 252 / 258 | 77% | 145.59 | 178 / 230 |
pancreas | 64% | 24137.83 | 209 / 328 | 88% | 98.26 | 156 / 178 |
breast | 94% | 69440.77 | 432 / 459 | 55% | 37.60 | 617 / 1118 |
thymus | 57% | 12352.45 | 371 / 653 | 92% | 286.57 | 558 / 605 |
prostate | 58% | 15738.49 | 142 / 245 | 76% | 54.31 | 384 / 502 |
kidney | 45% | 11575.29 | 40 / 89 | 81% | 368.12 | 728 / 901 |
ovary | 89% | 30673.96 | 161 / 180 | 26% | 8.10 | 111 / 430 |
lung | 73% | 21492.49 | 421 / 578 | 42% | 25.10 | 485 / 1155 |
intestine | 81% | 37331.07 | 782 / 966 | 34% | 16.56 | 178 / 527 |
liver | 35% | 5385.50 | 80 / 226 | 79% | 88.84 | 319 / 406 |
stomach | 65% | 25206.51 | 232 / 359 | 46% | 29.29 | 132 / 286 |
esophagus | 57% | 25954.44 | 829 / 1445 | 44% | 41.62 | 80 / 183 |
bladder | 71% | 31685.81 | 15 / 21 | 27% | 12.90 | 135 / 504 |
brain | 12% | 1649.62 | 322 / 2642 | 82% | 63.00 | 580 / 705 |
adipose | 94% | 66656.24 | 1134 / 1204 | 0% | 0 | 0 / 0 |
muscle | 92% | 234145.16 | 739 / 803 | 0% | 0 | 0 / 0 |
heart | 74% | 42524.64 | 640 / 861 | 0% | 0 | 0 / 0 |
spleen | 73% | 16474.13 | 177 / 241 | 0% | 0 | 0 / 0 |
skin | 34% | 8756.19 | 620 / 1809 | 37% | 25.39 | 175 / 472 |
uterus | 53% | 13721.48 | 90 / 170 | 18% | 14.11 | 82 / 459 |
blood vessel | 67% | 23488.44 | 895 / 1335 | 0% | 0 | 0 / 0 |
eye | 0% | 0 | 0 / 0 | 23% | 11.97 | 18 / 80 |
lymph node | 0% | 0 | 0 / 0 | 10% | 2.27 | 3 / 29 |
peripheral blood | 0% | 75.11 | 4 / 929 | 0% | 0 | 0 / 0 |
abdomen | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
bone marrow | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
diaphragm | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
gingiva | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
nasal cavity | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
nasopharynx | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
nose | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
placenta | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
spinal column | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
tonsil | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 45 |
ureter | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 1 |
GO_0045124 | Biological process | regulation of bone resorption |
GO_0010906 | Biological process | regulation of glucose metabolic process |
GO_2000811 | Biological process | negative regulation of anoikis |
GO_0006885 | Biological process | regulation of pH |
GO_0009267 | Biological process | cellular response to starvation |
GO_0010510 | Biological process | regulation of acetyl-CoA biosynthetic process from pyruvate |
GO_0042304 | Biological process | regulation of fatty acid biosynthetic process |
GO_0042594 | Biological process | response to starvation |
GO_0072593 | Biological process | reactive oxygen species metabolic process |
GO_0008286 | Biological process | insulin receptor signaling pathway |
GO_0010565 | Biological process | regulation of cellular ketone metabolic process |
GO_0006468 | Biological process | protein phosphorylation |
GO_0042593 | Biological process | glucose homeostasis |
GO_0046320 | Biological process | regulation of fatty acid oxidation |
GO_0071398 | Biological process | cellular response to fatty acid |
GO_0005739 | Cellular component | mitochondrion |
GO_0005759 | Cellular component | mitochondrial matrix |
GO_0004740 | Molecular function | pyruvate dehydrogenase (acetyl-transferring) kinase activity |
GO_0004672 | Molecular function | protein kinase activity |
GO_0005524 | Molecular function | ATP binding |
GO_0005515 | Molecular function | protein binding |
Gene name | PDK4 |
Protein name | [Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 4, mitochondrial (EC 2.7.11.2) (Pyruvate dehydrogenase kinase isoform 4) Protein-serine/threonine kinase (EC 2.7.11.-) |
Synonyms | tcag7.283 PDHK4 hCG_38945 |
Description | FUNCTION: Kinase that plays a key role in regulation of glucose and fatty acid metabolism and homeostasis via phosphorylation of the pyruvate dehydrogenase subunits PDHA1 and PDHA2. This inhibits pyruvate dehydrogenase activity, and thereby regulates metabolite flux through the tricarboxylic acid cycle, down-regulates aerobic respiration and inhibits the formation of acetyl-coenzyme A from pyruvate. Inhibition of pyruvate dehydrogenase decreases glucose utilization and increases fat metabolism in response to prolonged fasting and starvation. Plays an important role in maintaining normal blood glucose levels under starvation, and is involved in the insulin signaling cascade. Via its regulation of pyruvate dehydrogenase activity, plays an important role in maintaining normal blood pH and in preventing the accumulation of ketone bodies under starvation. In the fed state, mediates cellular responses to glucose levels and to a high-fat diet. Regulates both fatty acid oxidation and de novo fatty acid biosynthesis. Plays a role in the generation of reactive oxygen species. Protects detached epithelial cells against anoikis. Plays a role in cell proliferation via its role in regulating carbohydrate and fatty acid metabolism. . |
Accessions | ENST00000005178.6 Q16654 A4D1H4 B3KU25 |