PDK4 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0045124Biological processregulation of bone resorption
GO_0010906Biological processregulation of glucose metabolic process
GO_2000811Biological processnegative regulation of anoikis
GO_0006885Biological processregulation of pH
GO_0009267Biological processcellular response to starvation
GO_0010510Biological processregulation of acetyl-CoA biosynthetic process from pyruvate
GO_0042304Biological processregulation of fatty acid biosynthetic process
GO_0042594Biological processresponse to starvation
GO_0072593Biological processreactive oxygen species metabolic process
GO_0008286Biological processinsulin receptor signaling pathway
GO_0010565Biological processregulation of cellular ketone metabolic process
GO_0006468Biological processprotein phosphorylation
GO_0042593Biological processglucose homeostasis
GO_0046320Biological processregulation of fatty acid oxidation
GO_0071398Biological processcellular response to fatty acid
GO_0005739Cellular componentmitochondrion
GO_0005759Cellular componentmitochondrial matrix
GO_0004740Molecular functionpyruvate dehydrogenase (acetyl-transferring) kinase activity
GO_0004672Molecular functionprotein kinase activity
GO_0005524Molecular functionATP binding
GO_0005515Molecular functionprotein binding

IV. Literature review

[source]
Gene namePDK4
Protein name[Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 4, mitochondrial (EC 2.7.11.2) (Pyruvate dehydrogenase kinase isoform 4)
Protein-serine/threonine kinase (EC 2.7.11.-)
Synonymstcag7.283
PDHK4
hCG_38945
DescriptionFUNCTION: Kinase that plays a key role in regulation of glucose and fatty acid metabolism and homeostasis via phosphorylation of the pyruvate dehydrogenase subunits PDHA1 and PDHA2. This inhibits pyruvate dehydrogenase activity, and thereby regulates metabolite flux through the tricarboxylic acid cycle, down-regulates aerobic respiration and inhibits the formation of acetyl-coenzyme A from pyruvate. Inhibition of pyruvate dehydrogenase decreases glucose utilization and increases fat metabolism in response to prolonged fasting and starvation. Plays an important role in maintaining normal blood glucose levels under starvation, and is involved in the insulin signaling cascade. Via its regulation of pyruvate dehydrogenase activity, plays an important role in maintaining normal blood pH and in preventing the accumulation of ketone bodies under starvation. In the fed state, mediates cellular responses to glucose levels and to a high-fat diet. Regulates both fatty acid oxidation and de novo fatty acid biosynthesis. Plays a role in the generation of reactive oxygen species. Protects detached epithelial cells against anoikis. Plays a role in cell proliferation via its role in regulating carbohydrate and fatty acid metabolism. .

AccessionsENST00000005178.6
Q16654
A4D1H4
B3KU25