PCCA report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0019626Biological processshort-chain fatty acid catabolic process
GO_0009081Biological processbranched-chain amino acid metabolic process
GO_0006631Biological processfatty acid metabolic process
GO_1902494Cellular componentcatalytic complex
GO_0005829Cellular componentcytosol
GO_0005759Cellular componentmitochondrial matrix
GO_0005739Cellular componentmitochondrion
GO_0019899Molecular functionenzyme binding
GO_0004658Molecular functionpropionyl-CoA carboxylase activity
GO_0009374Molecular functionbiotin binding
GO_0005515Molecular functionprotein binding
GO_0046872Molecular functionmetal ion binding
GO_0005524Molecular functionATP binding

IV. Literature review

[source]
Gene namePCCA
Protein namePropionyl-CoA carboxylase subunit alpha
propionyl-CoA carboxylase (EC 6.4.1.3)
Propionyl-CoA carboxylase alpha chain, mitochondrial (EC 6.4.1.3) (Propanoyl-CoA:carbon dioxide ligase subunit alpha)
Propionyl-CoA carboxylase alpha chain, mitochondrial (PCCase subunit alpha) (EC 6.4.1.3) (Propanoyl-CoA:carbon dioxide ligase subunit alpha)
Synonyms
DescriptionFUNCTION: This is one of the 2 subunits of the biotin-dependent propionyl-CoA carboxylase (PCC), a mitochondrial enzyme involved in the catabolism of odd chain fatty acids, branched-chain amino acids isoleucine, threonine, methionine, and valine and other metabolites . Propionyl-CoA carboxylase catalyzes the carboxylation of propionyl-CoA/propanoyl-CoA to D-methylmalonyl-CoA/(S)-methylmalonyl-CoA . Within the holoenzyme, the alpha subunit catalyzes the ATP-dependent carboxylation of the biotin carried by the biotin carboxyl carrier (BCC) domain, while the beta subunit then transfers the carboxyl group from carboxylated biotin to propionyl-CoA (By similarity). Propionyl-CoA carboxylase also significantly acts on butyryl-CoA/butanoyl-CoA, which is converted to ethylmalonyl-CoA/(2S)-ethylmalonyl-CoA at a much lower rate . Other alternative minor substrates include (2E)-butenoyl-CoA/crotonoyl-CoA (By similarity). .

AccessionsENST00000376279.7 [P05165-3]
ENST00000637657.1
A0A1B0GU58
ENST00000636475.1
ENST00000428969.1
P05165
A0A1B0GWA1
Q5JTW6
ENST00000647303.1
H0Y5U0
ENST00000413170.1
ENST00000376286.8 [P05165-2]
ENST00000636420.1
ENST00000376285.6 [P05165-1]
A0A1B0GWI4
A0A1B0GUX9
ENST00000443601.1
ENST00000424527.5
A0A1B0GTR1
Q5JVH2
ENST00000637358.1
ENST00000636366.1
A0A2R8Y725
H0Y4B9
H0Y798
ENST00000458283.5