Name | Number of supported studies | Average coverage | |
|---|---|---|---|
| endothelial cell | 23 studies | 47% ± 19% | |
| astrocyte | 19 studies | 46% ± 21% | |
| microglial cell | 14 studies | 48% ± 17% | |
| oligodendrocyte precursor cell | 13 studies | 47% ± 19% | |
| oligodendrocyte | 13 studies | 42% ± 16% | |
| GABAergic neuron | 11 studies | 47% ± 23% | |
| glutamatergic neuron | 11 studies | 51% ± 25% | |
| macrophage | 11 studies | 39% ± 20% | |
| fibroblast | 11 studies | 40% ± 13% | |
| smooth muscle cell | 10 studies | 40% ± 18% | |
| pericyte | 10 studies | 42% ± 20% | |
| epithelial cell | 10 studies | 40% ± 23% | |
| adipocyte | 10 studies | 56% ± 18% | |
| endothelial cell of lymphatic vessel | 7 studies | 59% ± 15% | |
| interneuron | 6 studies | 59% ± 19% | |
| mast cell | 6 studies | 23% ± 7% | |
| kidney loop of Henle epithelial cell | 5 studies | 40% ± 28% | |
| neuron | 5 studies | 56% ± 17% | |
| cardiac muscle cell | 5 studies | 34% ± 9% | |
| dendritic cell | 5 studies | 23% ± 4% | |
| ciliated cell | 5 studies | 39% ± 13% | |
| myeloid cell | 5 studies | 33% ± 8% | |
| basal cell | 5 studies | 51% ± 21% | |
| type I pneumocyte | 5 studies | 32% ± 7% | |
| type II pneumocyte | 5 studies | 33% ± 8% | |
| cholangiocyte | 4 studies | 72% ± 13% | |
| hepatocyte | 4 studies | 78% ± 19% | |
| granule cell | 4 studies | 55% ± 2% | |
| Mueller cell | 4 studies | 44% ± 18% | |
| retina horizontal cell | 4 studies | 47% ± 19% | |
| retinal cone cell | 4 studies | 44% ± 17% | |
| retinal rod cell | 4 studies | 54% ± 12% | |
| T cell | 4 studies | 21% ± 3% | |
| club cell | 4 studies | 39% ± 9% | |
| monocyte | 4 studies | 37% ± 9% | |
| GABAergic interneuron | 3 studies | 43% ± 1% | |
| glial cell | 3 studies | 34% ± 12% | |
| plasma cell | 3 studies | 27% ± 8% | |
| CD4-positive, alpha-beta T cell | 3 studies | 17% ± 1% | |
| vein endothelial cell | 3 studies | 40% ± 21% | |
| amacrine cell | 3 studies | 42% ± 14% | |
| glycinergic amacrine cell | 3 studies | 39% ± 14% | |
| retinal ganglion cell | 3 studies | 54% ± 15% | |
| endothelial cell of vascular tree | 3 studies | 43% ± 19% | |
| retinal pigment epithelial cell | 3 studies | 46% ± 26% | |
| connective tissue cell | 3 studies | 35% ± 14% | |
| ependymal cell | 3 studies | 54% ± 14% | |
| megakaryocyte-erythroid progenitor cell | 3 studies | 20% ± 4% | |
| alveolar macrophage | 3 studies | 53% ± 10% | |
| capillary endothelial cell | 3 studies | 33% ± 10% | |
| natural killer cell | 3 studies | 24% ± 3% | |
| respiratory goblet cell | 3 studies | 44% ± 16% | |
| transit amplifying cell | 3 studies | 41% ± 30% | |
| mesothelial cell | 3 studies | 38% ± 12% | |
| kidney distal convoluted tubule epithelial cell | 3 studies | 55% ± 26% | |
| mucus secreting cell | 3 studies | 48% ± 17% |
Tissue | GTEx Coverage | GTEx Average TPM | GTEx Number of samples | TCGA Coverage | TCGA Average TPM | TCGA Number of samples |
|---|---|---|---|---|---|---|
| prostate | 100% | 1458.91 | 245 / 245 | 99% | 20.09 | 499 / 502 |
| brain | 99% | 1058.32 | 2618 / 2642 | 99% | 11.98 | 701 / 705 |
| pancreas | 99% | 900.10 | 326 / 328 | 97% | 7.37 | 173 / 178 |
| kidney | 100% | 3961.96 | 89 / 89 | 97% | 20.53 | 870 / 901 |
| liver | 100% | 2910.50 | 226 / 226 | 97% | 16.98 | 392 / 406 |
| thymus | 100% | 1483.12 | 653 / 653 | 96% | 10.63 | 581 / 605 |
| intestine | 100% | 1829.54 | 966 / 966 | 95% | 20.70 | 501 / 527 |
| breast | 100% | 1877.20 | 459 / 459 | 93% | 9.13 | 1041 / 1118 |
| stomach | 100% | 2037.96 | 359 / 359 | 93% | 14.06 | 265 / 286 |
| bladder | 100% | 1442.48 | 21 / 21 | 92% | 12.69 | 464 / 504 |
| uterus | 100% | 1181.93 | 170 / 170 | 89% | 8.43 | 408 / 459 |
| lung | 99% | 873.34 | 573 / 578 | 89% | 6.63 | 1027 / 1155 |
| adrenal gland | 100% | 4073.16 | 258 / 258 | 87% | 8.44 | 199 / 230 |
| skin | 100% | 1067.71 | 1808 / 1809 | 82% | 7.52 | 388 / 472 |
| ovary | 100% | 1402.41 | 180 / 180 | 82% | 5.30 | 352 / 430 |
| esophagus | 100% | 1374.25 | 1444 / 1445 | 77% | 5.15 | 141 / 183 |
| adipose | 100% | 1800.33 | 1204 / 1204 | 0% | 0 | 0 / 0 |
| blood vessel | 100% | 1203.80 | 1335 / 1335 | 0% | 0 | 0 / 0 |
| spleen | 100% | 943.86 | 241 / 241 | 0% | 0 | 0 / 0 |
| muscle | 100% | 843.94 | 801 / 803 | 0% | 0 | 0 / 0 |
| heart | 93% | 1368.21 | 799 / 861 | 0% | 0 | 0 / 0 |
| tonsil | 0% | 0 | 0 / 0 | 82% | 5.29 | 37 / 45 |
| eye | 0% | 0 | 0 / 0 | 81% | 5.09 | 65 / 80 |
| lymph node | 0% | 0 | 0 / 0 | 66% | 3.02 | 19 / 29 |
| peripheral blood | 36% | 208.49 | 330 / 929 | 0% | 0 | 0 / 0 |
| abdomen | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| bone marrow | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| diaphragm | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| gingiva | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nasal cavity | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nasopharynx | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nose | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| placenta | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| spinal column | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| ureter | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 1 |
| GO_0019626 | Biological process | short-chain fatty acid catabolic process |
| GO_0009081 | Biological process | branched-chain amino acid metabolic process |
| GO_0006631 | Biological process | fatty acid metabolic process |
| GO_1902494 | Cellular component | catalytic complex |
| GO_0005829 | Cellular component | cytosol |
| GO_0005759 | Cellular component | mitochondrial matrix |
| GO_0005739 | Cellular component | mitochondrion |
| GO_0019899 | Molecular function | enzyme binding |
| GO_0004658 | Molecular function | propionyl-CoA carboxylase activity |
| GO_0009374 | Molecular function | biotin binding |
| GO_0005515 | Molecular function | protein binding |
| GO_0046872 | Molecular function | metal ion binding |
| GO_0005524 | Molecular function | ATP binding |
| Gene name | PCCA |
| Protein name | Propionyl-CoA carboxylase subunit alpha propionyl-CoA carboxylase (EC 6.4.1.3) Propionyl-CoA carboxylase alpha chain, mitochondrial (EC 6.4.1.3) (Propanoyl-CoA:carbon dioxide ligase subunit alpha) Propionyl-CoA carboxylase alpha chain, mitochondrial (PCCase subunit alpha) (EC 6.4.1.3) (Propanoyl-CoA:carbon dioxide ligase subunit alpha) |
| Synonyms | |
| Description | FUNCTION: This is one of the 2 subunits of the biotin-dependent propionyl-CoA carboxylase (PCC), a mitochondrial enzyme involved in the catabolism of odd chain fatty acids, branched-chain amino acids isoleucine, threonine, methionine, and valine and other metabolites . Propionyl-CoA carboxylase catalyzes the carboxylation of propionyl-CoA/propanoyl-CoA to D-methylmalonyl-CoA/(S)-methylmalonyl-CoA . Within the holoenzyme, the alpha subunit catalyzes the ATP-dependent carboxylation of the biotin carried by the biotin carboxyl carrier (BCC) domain, while the beta subunit then transfers the carboxyl group from carboxylated biotin to propionyl-CoA (By similarity). Propionyl-CoA carboxylase also significantly acts on butyryl-CoA/butanoyl-CoA, which is converted to ethylmalonyl-CoA/(2S)-ethylmalonyl-CoA at a much lower rate . Other alternative minor substrates include (2E)-butenoyl-CoA/crotonoyl-CoA (By similarity). . |
| Accessions | ENST00000376279.7 [P05165-3] ENST00000637657.1 A0A1B0GU58 ENST00000636475.1 ENST00000428969.1 P05165 A0A1B0GWA1 Q5JTW6 ENST00000647303.1 H0Y5U0 ENST00000413170.1 ENST00000376286.8 [P05165-2] ENST00000636420.1 ENST00000376285.6 [P05165-1] A0A1B0GWI4 A0A1B0GUX9 ENST00000443601.1 ENST00000424527.5 A0A1B0GTR1 Q5JVH2 ENST00000637358.1 ENST00000636366.1 A0A2R8Y725 H0Y4B9 H0Y798 ENST00000458283.5 |