PATJ report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0035089Biological processestablishment of apical/basal cell polarity
GO_0045197Biological processestablishment or maintenance of epithelial cell apical/basal polarity
GO_0035556Biological processintracellular signal transduction
GO_0120192Biological processtight junction assembly
GO_0016324Cellular componentapical plasma membrane
GO_0030054Cellular componentcell junction
GO_0043296Cellular componentapical junction complex
GO_0070062Cellular componentextracellular exosome
GO_0005829Cellular componentcytosol
GO_0045177Cellular componentapical part of cell
GO_0005886Cellular componentplasma membrane
GO_0034451Cellular componentcentriolar satellite
GO_0048471Cellular componentperinuclear region of cytoplasm
GO_0005737Cellular componentcytoplasm
GO_0005923Cellular componentbicellular tight junction
GO_0005515Molecular functionprotein binding

IV. Literature review

[source]
Gene namePATJ
Protein namePATJ crumbs cell polarity complex component
INADL protein
InaD-like protein (Inadl protein) (hINADL) (Channel-interacting PDZ domain-containing protein) (Pals1-associated tight junction protein) (Protein associated to tight junctions)
PATJ crumbs cell polarity complex component (cDNA FLJ59473, highly similar to InaD-like protein)
SynonymsCIPP
INADL
DescriptionFUNCTION: Scaffolding protein that facilitates the localization of proteins to the cell membrane . Required for the correct formation of tight junctions and epithelial apico-basal polarity . Positively regulates epithelial cell microtubule elongation and cell migration, possibly via facilitating localization of PRKCI/aPKC and PAR3D/PAR3 at the leading edge of migrating cells (By similarity). Plays a role in the correct reorientation of the microtubule-organizing center during epithelial migration (By similarity). May regulate the surface expression and/or function of ASIC3 in sensory neurons (By similarity). May recruit ARHGEF18 to apical cell-cell boundaries . .

AccessionsA0A0U1RQR3
A0A0U1RQT2
ENST00000371158.6 [Q8NI35-1]
A0A2R8Y5I3
ENST00000635137.1
ENST00000465798.2
Q8NI35
A0A0U1RR46
ENST00000484937.5 [Q8NI35-5]
A0A2R8Y549
ENST00000307297.8
B4DE90
ENST00000494842.2
ENST00000646453.1
ENST00000490547.2
A5PKX9
ENST00000635023.1
A0A0U1RQW4
A0A0U1RRD7
ENST00000642238.2