PARN report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_1990431Biological processpriRNA 3'-end processing
GO_0000495Biological processbox H/ACA sno(s)RNA 3'-end processing
GO_0071051Biological processpoly(A)-dependent snoRNA 3'-end processing
GO_1990432Biological processsiRNA 3'-end processing
GO_0010587Biological processmiRNA catabolic process
GO_0000184Biological processnuclear-transcribed mRNA catabolic process, nonsense-mediated decay
GO_0009451Biological processRNA modification
GO_1904872Biological processregulation of telomerase RNA localization to Cajal body
GO_0000289Biological processnuclear-transcribed mRNA poly(A) tail shortening
GO_0090669Biological processtelomerase RNA stabilization
GO_0032212Biological processpositive regulation of telomere maintenance via telomerase
GO_0007292Biological processfemale gamete generation
GO_0098978Cellular componentglutamatergic synapse
GO_0005730Cellular componentnucleolus
GO_0016607Cellular componentnuclear speck
GO_0098794Cellular componentpostsynapse
GO_0005829Cellular componentcytosol
GO_0005737Cellular componentcytoplasm
GO_0005634Cellular componentnucleus
GO_0019901Molecular functionprotein kinase binding
GO_0004518Molecular functionnuclease activity
GO_0046872Molecular functionmetal ion binding
GO_0003723Molecular functionRNA binding
GO_0070034Molecular functiontelomerase RNA binding
GO_0000175Molecular function3'-5'-RNA exonuclease activity
GO_0004535Molecular functionpoly(A)-specific ribonuclease activity
GO_0043169Molecular functioncation binding
GO_0003730Molecular functionmRNA 3'-UTR binding
GO_0005515Molecular functionprotein binding

IV. Literature review

[source]
Gene namePARN
Protein namePoly(A)-specific ribonuclease PARN (EC 3.1.13.4) (Deadenylating nuclease) (Deadenylation nuclease) (Polyadenylate-specific ribonuclease)
Poly(A)-specific ribonuclease
Poly(A)-specific ribonuclease PARN (Polyadenylate-specific ribonuclease)
Poly(A)-specific ribonuclease PARN (EC 3.1.13.4) (Polyadenylate-specific ribonuclease)
SynonymsDAN
DescriptionFUNCTION: 3'-exoribonuclease that has a preference for poly(A) tails of mRNAs, thereby efficiently degrading poly(A) tails. Exonucleolytic degradation of the poly(A) tail is often the first step in the decay of eukaryotic mRNAs and is also used to silence certain maternal mRNAs translationally during oocyte maturation and early embryonic development. Interacts with both the 3'-end poly(A) tail and the 5'-end cap structure during degradation, the interaction with the cap structure being required for an efficient degradation of poly(A) tails. Involved in nonsense-mediated mRNA decay, a critical process of selective degradation of mRNAs that contain premature stop codons. Also involved in degradation of inherently unstable mRNAs that contain AU-rich elements (AREs) in their 3'-UTR, possibly via its interaction with KHSRP. Probably mediates the removal of poly(A) tails of AREs mRNAs, which constitutes the first step of destabilization . Also able to recognize and trim poly(A) tails of microRNAs such as MIR21 and H/ACA box snoRNAs (small nucleolar RNAs) leading to microRNAs degradation or snoRNA increased stability . .

AccessionsA0A494BZU6
ENST00000634004.1 [O95453-2]
A0A494C0Q2
ENST00000632860.1
A0A494C0K5
ENST00000631868.1 [O95453-4]
A0A494C0N0
ENST00000651760.1
A0A494C1N1
ENST00000652541.1
ENST00000341484.11 [O95453-2]
ENST00000652051.1
ENST00000651865.1
A0A494C1K5
ENST00000697474.1
ENST00000562896.1
ENST00000652501.1
ENST00000618929.2 [O95453-3]
H3BT23
ENST00000651049.1
A0A494C002
ENST00000651027.1
ENST00000538472.5
A0A494BZW7
H3BVG1
ENST00000569444.5
ENST00000651634.1
ENST00000651300.1
H3BRK1
ENST00000650990.1
ENST00000420015.6 [O95453-3]
ENST00000563641.6
ENST00000437198.7 [O95453-1]
ENST00000634095.1
ENST00000652066.1
O95453
A0A494C008
ENST00000633129.1
A0A494C1G3
ENST00000615183.4 [O95453-1]
A0A494C156
ENST00000651348.1
ENST00000651913.1
F5H1Z4
ENST00000652727.1
A0A494C0Q6
A0A494C0P9
A0A8V8TMN8
ENST00000650960.1
A0A494C0W0
ENST00000632226.1
ENST00000539279.5 [O95453-4]