Name | Number of supported studies | Average coverage | |
---|---|---|---|
endothelial cell | 12 studies | 25% ± 9% | |
oligodendrocyte | 8 studies | 29% ± 10% | |
fibroblast | 7 studies | 22% ± 9% | |
adipocyte | 7 studies | 25% ± 6% | |
astrocyte | 7 studies | 34% ± 16% | |
dendritic cell | 6 studies | 18% ± 2% | |
glutamatergic neuron | 5 studies | 37% ± 23% | |
microglial cell | 5 studies | 29% ± 7% | |
epithelial cell | 5 studies | 30% ± 14% | |
macrophage | 5 studies | 30% ± 8% | |
type I pneumocyte | 5 studies | 24% ± 4% | |
type II pneumocyte | 5 studies | 26% ± 5% | |
club cell | 4 studies | 23% ± 5% | |
endothelial cell of lymphatic vessel | 4 studies | 20% ± 3% | |
basal cell | 4 studies | 28% ± 18% | |
interneuron | 4 studies | 39% ± 21% | |
GABAergic neuron | 4 studies | 38% ± 21% | |
neuron | 3 studies | 29% ± 14% | |
ciliated cell | 3 studies | 22% ± 5% | |
myeloid cell | 3 studies | 21% ± 5% | |
hepatocyte | 3 studies | 30% ± 12% | |
abnormal cell | 3 studies | 25% ± 9% | |
T cell | 3 studies | 17% ± 1% | |
alveolar macrophage | 3 studies | 24% ± 6% | |
monocyte | 3 studies | 23% ± 3% | |
pericyte | 3 studies | 19% ± 5% | |
lymphocyte | 3 studies | 25% ± 6% | |
goblet cell | 3 studies | 29% ± 12% | |
transit amplifying cell | 3 studies | 34% ± 24% | |
mast cell | 3 studies | 18% ± 2% | |
oligodendrocyte precursor cell | 3 studies | 30% ± 7% |
Tissue | GTEx Coverage | GTEx Average TPM | GTEx Number of samples | TCGA Coverage | TCGA Average TPM | TCGA Number of samples |
---|---|---|---|---|---|---|
breast | 100% | 2584.36 | 459 / 459 | 100% | 34.94 | 1118 / 1118 |
esophagus | 100% | 2516.38 | 1445 / 1445 | 100% | 18.45 | 183 / 183 |
prostate | 100% | 2604.82 | 245 / 245 | 100% | 19.19 | 502 / 502 |
skin | 100% | 2756.05 | 1809 / 1809 | 100% | 28.41 | 472 / 472 |
stomach | 100% | 1962.29 | 359 / 359 | 100% | 17.98 | 286 / 286 |
thymus | 100% | 2985.63 | 653 / 653 | 100% | 25.47 | 605 / 605 |
uterus | 100% | 2754.38 | 170 / 170 | 100% | 22.50 | 459 / 459 |
lung | 100% | 2326.71 | 578 / 578 | 100% | 22.62 | 1154 / 1155 |
intestine | 100% | 2650.69 | 966 / 966 | 100% | 19.21 | 526 / 527 |
bladder | 100% | 2884.81 | 21 / 21 | 100% | 20.52 | 503 / 504 |
kidney | 100% | 1747.27 | 89 / 89 | 100% | 18.64 | 899 / 901 |
ovary | 100% | 2420.58 | 180 / 180 | 100% | 15.35 | 429 / 430 |
brain | 99% | 1506.98 | 2625 / 2642 | 100% | 18.49 | 705 / 705 |
pancreas | 100% | 1399.82 | 327 / 328 | 99% | 19.97 | 177 / 178 |
adrenal gland | 100% | 2936.59 | 258 / 258 | 99% | 15.74 | 227 / 230 |
liver | 100% | 1308.05 | 226 / 226 | 99% | 10.89 | 400 / 406 |
adipose | 100% | 2379.82 | 1204 / 1204 | 0% | 0 | 0 / 0 |
blood vessel | 100% | 2716.12 | 1335 / 1335 | 0% | 0 | 0 / 0 |
lymph node | 0% | 0 | 0 / 0 | 100% | 37.05 | 29 / 29 |
spleen | 100% | 2390.22 | 241 / 241 | 0% | 0 | 0 / 0 |
tonsil | 0% | 0 | 0 / 0 | 100% | 19.42 | 45 / 45 |
ureter | 0% | 0 | 0 / 0 | 100% | 11.18 | 1 / 1 |
muscle | 100% | 1474.93 | 799 / 803 | 0% | 0 | 0 / 0 |
eye | 0% | 0 | 0 / 0 | 99% | 21.25 | 79 / 80 |
heart | 97% | 1460.25 | 838 / 861 | 0% | 0 | 0 / 0 |
peripheral blood | 94% | 1713.78 | 869 / 929 | 0% | 0 | 0 / 0 |
abdomen | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
bone marrow | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
diaphragm | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
gingiva | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
nasal cavity | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
nasopharynx | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
nose | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
placenta | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
spinal column | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
GO_1990431 | Biological process | priRNA 3'-end processing |
GO_0000495 | Biological process | box H/ACA sno(s)RNA 3'-end processing |
GO_0071051 | Biological process | poly(A)-dependent snoRNA 3'-end processing |
GO_1990432 | Biological process | siRNA 3'-end processing |
GO_0010587 | Biological process | miRNA catabolic process |
GO_0000184 | Biological process | nuclear-transcribed mRNA catabolic process, nonsense-mediated decay |
GO_0009451 | Biological process | RNA modification |
GO_1904872 | Biological process | regulation of telomerase RNA localization to Cajal body |
GO_0000289 | Biological process | nuclear-transcribed mRNA poly(A) tail shortening |
GO_0090669 | Biological process | telomerase RNA stabilization |
GO_0032212 | Biological process | positive regulation of telomere maintenance via telomerase |
GO_0007292 | Biological process | female gamete generation |
GO_0098978 | Cellular component | glutamatergic synapse |
GO_0005730 | Cellular component | nucleolus |
GO_0016607 | Cellular component | nuclear speck |
GO_0098794 | Cellular component | postsynapse |
GO_0005829 | Cellular component | cytosol |
GO_0005737 | Cellular component | cytoplasm |
GO_0005634 | Cellular component | nucleus |
GO_0019901 | Molecular function | protein kinase binding |
GO_0004518 | Molecular function | nuclease activity |
GO_0046872 | Molecular function | metal ion binding |
GO_0003723 | Molecular function | RNA binding |
GO_0070034 | Molecular function | telomerase RNA binding |
GO_0000175 | Molecular function | 3'-5'-RNA exonuclease activity |
GO_0004535 | Molecular function | poly(A)-specific ribonuclease activity |
GO_0043169 | Molecular function | cation binding |
GO_0003730 | Molecular function | mRNA 3'-UTR binding |
GO_0005515 | Molecular function | protein binding |
Gene name | PARN |
Protein name | Poly(A)-specific ribonuclease PARN (EC 3.1.13.4) (Deadenylating nuclease) (Deadenylation nuclease) (Polyadenylate-specific ribonuclease) Poly(A)-specific ribonuclease Poly(A)-specific ribonuclease PARN (Polyadenylate-specific ribonuclease) Poly(A)-specific ribonuclease PARN (EC 3.1.13.4) (Polyadenylate-specific ribonuclease) |
Synonyms | DAN |
Description | FUNCTION: 3'-exoribonuclease that has a preference for poly(A) tails of mRNAs, thereby efficiently degrading poly(A) tails. Exonucleolytic degradation of the poly(A) tail is often the first step in the decay of eukaryotic mRNAs and is also used to silence certain maternal mRNAs translationally during oocyte maturation and early embryonic development. Interacts with both the 3'-end poly(A) tail and the 5'-end cap structure during degradation, the interaction with the cap structure being required for an efficient degradation of poly(A) tails. Involved in nonsense-mediated mRNA decay, a critical process of selective degradation of mRNAs that contain premature stop codons. Also involved in degradation of inherently unstable mRNAs that contain AU-rich elements (AREs) in their 3'-UTR, possibly via its interaction with KHSRP. Probably mediates the removal of poly(A) tails of AREs mRNAs, which constitutes the first step of destabilization . Also able to recognize and trim poly(A) tails of microRNAs such as MIR21 and H/ACA box snoRNAs (small nucleolar RNAs) leading to microRNAs degradation or snoRNA increased stability . . |
Accessions | A0A494BZU6 ENST00000634004.1 [O95453-2] A0A494C0Q2 ENST00000632860.1 A0A494C0K5 ENST00000631868.1 [O95453-4] A0A494C0N0 ENST00000651760.1 A0A494C1N1 ENST00000652541.1 ENST00000341484.11 [O95453-2] ENST00000652051.1 ENST00000651865.1 A0A494C1K5 ENST00000697474.1 ENST00000562896.1 ENST00000652501.1 ENST00000618929.2 [O95453-3] H3BT23 ENST00000651049.1 A0A494C002 ENST00000651027.1 ENST00000538472.5 A0A494BZW7 H3BVG1 ENST00000569444.5 ENST00000651634.1 ENST00000651300.1 H3BRK1 ENST00000650990.1 ENST00000420015.6 [O95453-3] ENST00000563641.6 ENST00000437198.7 [O95453-1] ENST00000634095.1 ENST00000652066.1 O95453 A0A494C008 ENST00000633129.1 A0A494C1G3 ENST00000615183.4 [O95453-1] A0A494C156 ENST00000651348.1 ENST00000651913.1 F5H1Z4 ENST00000652727.1 A0A494C0Q6 A0A494C0P9 A0A8V8TMN8 ENST00000650960.1 A0A494C0W0 ENST00000632226.1 ENST00000539279.5 [O95453-4] |