PALS1 | OmnibusX

I. Expression across cell types

Name	Number of supported studies	Average coverage
oligodendrocyte	10 studies	36% ± 11%	Explore
type I pneumocyte	8 studies	24% ± 9%	Explore
astrocyte	7 studies	27% ± 11%	Explore
podocyte	5 studies	65% ± 10%	Explore
epithelial cell	5 studies	41% ± 12%	Explore
adipocyte	5 studies	23% ± 4%	Explore
endothelial cell of lymphatic vessel	5 studies	20% ± 6%	Explore
oligodendrocyte precursor cell	5 studies	26% ± 10%	Explore
macrophage	5 studies	22% ± 2%	Explore
endothelial cell	5 studies	22% ± 4%	Explore
ciliated cell	3 studies	24% ± 3%	Explore
retinal rod cell	3 studies	22% ± 5%	Explore
GABAergic neuron	3 studies	48% ± 11%	Explore
glutamatergic neuron	3 studies	53% ± 11%	Explore
fibroblast	3 studies	17% ± 2%	Explore

II. Expression across tissues

Name	Number of supported studies	Average coverage
brain	7 studies	35% ± 15%	Explore

Tissue	GTEx Coverage	GTEx Average TPM	GTEx Number of samples	TCGA Coverage	TCGA Average TPM	TCGA Number of samples
esophagus	100%	2338.43	1445 / 1445	100%	9.51	183 / 183
prostate	100%	2210.34	245 / 245	100%	14.50	502 / 502
brain	100%	2387.46	2642 / 2642	100%	12.40	704 / 705
lung	100%	2163.85	578 / 578	99%	7.72	1147 / 1155
ovary	100%	1105.38	180 / 180	99%	5.96	425 / 430
breast	100%	1648.51	459 / 459	99%	9.74	1103 / 1118
thymus	100%	3503.55	653 / 653	98%	13.81	595 / 605
intestine	100%	2167.38	966 / 966	98%	7.09	516 / 527
stomach	100%	1695.64	359 / 359	98%	6.78	280 / 286
uterus	100%	1407.16	170 / 170	97%	7.13	447 / 459
pancreas	99%	957.61	324 / 328	98%	7.31	175 / 178
kidney	100%	3048.76	89 / 89	97%	9.06	871 / 901
bladder	100%	1757.14	21 / 21	97%	6.64	487 / 504
skin	100%	2049.03	1808 / 1809	90%	6.06	424 / 472
adrenal gland	100%	1798.63	258 / 258	89%	4.83	205 / 230
liver	100%	1257.32	226 / 226	88%	4.28	356 / 406
adipose	100%	1533.88	1204 / 1204	0%	0	0 / 0
muscle	100%	1957.38	803 / 803	0%	0	0 / 0
spleen	100%	1232.82	241 / 241	0%	0	0 / 0
tonsil	0%	0	0 / 0	100%	7.01	45 / 45
ureter	0%	0	0 / 0	100%	2.18	1 / 1
blood vessel	100%	1726.81	1334 / 1335	0%	0	0 / 0
heart	93%	972.70	804 / 861	0%	0	0 / 0
eye	0%	0	0 / 0	71%	3.45	57 / 80
lymph node	0%	0	0 / 0	62%	1.97	18 / 29
peripheral blood	29%	359.88	269 / 929	0%	0	0 / 0
abdomen	0%	0	0 / 0	0%	0	0 / 0
bone marrow	0%	0	0 / 0	0%	0	0 / 0
diaphragm	0%	0	0 / 0	0%	0	0 / 0
gingiva	0%	0	0 / 0	0%	0	0 / 0
nasal cavity	0%	0	0 / 0	0%	0	0 / 0
nasopharynx	0%	0	0 / 0	0%	0	0 / 0
nose	0%	0	0 / 0	0%	0	0 / 0
placenta	0%	0	0 / 0	0%	0	0 / 0
spinal column	0%	0	0 / 0	0%	0	0 / 0

III. Associated gene sets

GO_0017015	Biological process	regulation of transforming growth factor beta receptor signaling pathway
GO_0072659	Biological process	protein localization to plasma membrane
GO_0002011	Biological process	morphogenesis of an epithelial sheet
GO_0032288	Biological process	myelin assembly
GO_0048699	Biological process	generation of neurons
GO_0035750	Biological process	protein localization to myelin sheath abaxonal region
GO_0032287	Biological process	peripheral nervous system myelin maintenance
GO_0016332	Biological process	establishment or maintenance of polarity of embryonic epithelium
GO_0021954	Biological process	central nervous system neuron development
GO_0010467	Biological process	gene expression
GO_0021987	Biological process	cerebral cortex development
GO_0045197	Biological process	establishment or maintenance of epithelial cell apical/basal polarity
GO_0016324	Cellular component	apical plasma membrane
GO_0043219	Cellular component	lateral loop
GO_0005886	Cellular component	plasma membrane
GO_0043204	Cellular component	perikaryon
GO_0032991	Cellular component	protein-containing complex
GO_0070062	Cellular component	extracellular exosome
GO_0005794	Cellular component	Golgi apparatus
GO_0043220	Cellular component	Schmidt-Lanterman incisure
GO_0033116	Cellular component	endoplasmic reticulum-Golgi intermediate compartment membrane
GO_0043296	Cellular component	apical junction complex
GO_0005912	Cellular component	adherens junction
GO_0005737	Cellular component	cytoplasm
GO_0005923	Cellular component	bicellular tight junction
GO_0030424	Cellular component	axon
GO_0035749	Cellular component	myelin sheath adaxonal region
GO_0019904	Molecular function	protein domain specific binding
GO_0042802	Molecular function	identical protein binding
GO_0005524	Molecular function	ATP binding
GO_0005515	Molecular function	protein binding

IV. Literature review

[source]

Gene name	PALS1
Protein name	Protein associated with LIN7 1, MAGUK p55 family member Protein PALS1 (MAGUK p55 subfamily member 5) (Membrane protein, palmitoylated 5) (Protein associated with Lin-7 1) Protein PALS1 (MAGUK p55 subfamily member 5) (Protein associated with Lin-7 1)
Synonyms	MPP5
Description	FUNCTION: Plays a role in tight junction biogenesis and in the establishment of cell polarity in epithelial cells . Also involved in adherens junction biogenesis by ensuring correct localization of the exocyst complex protein EXOC4/SEC8 which allows trafficking of adherens junction structural component CDH1 to the cell surface (By similarity). Plays a role through its interaction with CDH5 in vascular lumen formation and endothelial membrane polarity . Required during embryonic and postnatal retinal development (By similarity). Required for the maintenance of cerebellar progenitor cells in an undifferentiated proliferative state, preventing premature differentiation, and is required for cerebellar histogenesis, fissure formation, cerebellar layer organization and cortical development (By similarity). Plays a role in neuronal progenitor cell survival, potentially via promotion of mTOR signaling (By similarity). Plays a role in the radial and longitudinal extension of the myelin sheath in Schwann cells (By similarity). May modulate SC6A1/GAT1-mediated GABA uptake by stabilizing the transporter (By similarity). Plays a role in the T-cell receptor-mediated activation of NF-kappa-B . Required for localization of EZR to the apical membrane of parietal cells and may play a role in the dynamic remodeling of the apical cytoskeleton (By similarity). Required for the normal polarized localization of the vesicular marker STX4 (By similarity). Required for the correct trafficking of the myelin proteins PMP22 and MAG (By similarity). Involved in promoting phosphorylation and cytoplasmic retention of transcriptional coactivators YAP1 and WWTR1/TAZ which leads to suppression of TGFB1-dependent transcription of target genes such as CCN2/CTGF, SERPINE1/PAI1, SNAI1/SNAIL1 and SMAD7 (By similarity). .; FUNCTION: (Microbial infection) Acts as an interaction partner for human coronaviruses SARS-CoV and, probably, SARS-CoV-2 envelope protein E which results in delayed formation of tight junctions and disregulation of cell polarity. .
Accessions	Q4VBP4 Q8N3R9 ENST00000261681.9 [Q8N3R9-1] G3V2H1 ENST00000557783.1 ENST00000677835.1 [Q8N3R9-1] ENST00000678380.1 [Q8N3R9-1] ENST00000677382.1 [Q8N3R9-1] ENST00000676464.1 [Q8N3R9-1] ENST00000555925.5 [Q8N3R9-2] G3V2B0 ENST00000556345.6

PALS1 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

IV. Literature review