Name | Number of supported studies  | Average coverage | |
|---|---|---|---|
| peripheral blood | 5 studies | 25% ± 10% |
Tissue | GTEx Coverage | GTEx Average TPM | GTEx Number of samples | TCGA Coverage | TCGA Average TPM | TCGA Number of samples |
|---|---|---|---|---|---|---|
| skin | 100% | 865.47 | 1809 / 1809 | 100% | 51.93 | 472 / 472 |
| uterus | 100% | 355.01 | 170 / 170 | 100% | 62.29 | 459 / 459 |
| brain | 100% | 359.26 | 2632 / 2642 | 100% | 37.51 | 705 / 705 |
| ovary | 100% | 245.57 | 180 / 180 | 99% | 19.39 | 425 / 430 |
| bladder | 100% | 380.43 | 21 / 21 | 99% | 42.09 | 497 / 504 |
| esophagus | 100% | 471.36 | 1445 / 1445 | 98% | 24.98 | 180 / 183 |
| intestine | 100% | 456.34 | 966 / 966 | 98% | 34.84 | 517 / 527 |
| breast | 100% | 406.29 | 459 / 459 | 97% | 26.36 | 1087 / 1118 |
| lung | 99% | 344.20 | 575 / 578 | 97% | 32.96 | 1123 / 1155 |
| stomach | 98% | 259.21 | 351 / 359 | 98% | 27.33 | 281 / 286 |
| prostate | 100% | 318.55 | 244 / 245 | 96% | 14.72 | 482 / 502 |
| thymus | 98% | 230.02 | 643 / 653 | 95% | 29.85 | 573 / 605 |
| kidney | 97% | 222.78 | 86 / 89 | 92% | 14.60 | 825 / 901 |
| pancreas | 82% | 122.74 | 268 / 328 | 97% | 24.92 | 173 / 178 |
| adrenal gland | 97% | 205.39 | 251 / 258 | 71% | 10.60 | 164 / 230 |
| liver | 49% | 68.52 | 111 / 226 | 74% | 14.36 | 300 / 406 |
| adipose | 100% | 444.39 | 1204 / 1204 | 0% | 0 | 0 / 0 |
| eye | 0% | 0 | 0 / 0 | 100% | 37.22 | 80 / 80 |
| lymph node | 0% | 0 | 0 / 0 | 100% | 135.42 | 29 / 29 |
| peripheral blood | 100% | 657.42 | 929 / 929 | 0% | 0 | 0 / 0 |
| spleen | 100% | 813.41 | 241 / 241 | 0% | 0 | 0 / 0 |
| tonsil | 0% | 0 | 0 / 0 | 100% | 72.07 | 45 / 45 |
| ureter | 0% | 0 | 0 / 0 | 100% | 34.22 | 1 / 1 |
| blood vessel | 100% | 369.49 | 1332 / 1335 | 0% | 0 | 0 / 0 |
| muscle | 99% | 274.78 | 793 / 803 | 0% | 0 | 0 / 0 |
| heart | 97% | 299.27 | 839 / 861 | 0% | 0 | 0 / 0 |
| abdomen | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| bone marrow | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| diaphragm | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| gingiva | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nasal cavity | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nasopharynx | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nose | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| placenta | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| spinal column | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| GO_0006281 | Biological process | DNA repair |
| GO_0046686 | Biological process | response to cadmium ion |
| GO_0042262 | Biological process | DNA protection |
| GO_0006152 | Biological process | purine nucleoside catabolic process |
| GO_0008584 | Biological process | male gonad development |
| GO_0006979 | Biological process | response to oxidative stress |
| GO_0005615 | Cellular component | extracellular space |
| GO_0001669 | Cellular component | acrosomal vesicle |
| GO_0005739 | Cellular component | mitochondrion |
| GO_0005829 | Cellular component | cytosol |
| GO_0005759 | Cellular component | mitochondrial matrix |
| GO_0005737 | Cellular component | cytoplasm |
| GO_0031965 | Cellular component | nuclear membrane |
| GO_0005634 | Cellular component | nucleus |
| GO_0106377 | Molecular function | 2-hydroxy-ATP hydrolase activity |
| GO_0106431 | Molecular function | N6-methyl-(d)ATP hydrolase activity |
| GO_0035539 | Molecular function | 8-oxo-7,8-dihydrodeoxyguanosine triphosphate pyrophosphatase activity |
| GO_0106433 | Molecular function | O6-methyl-dGTP hydrolase activity |
| GO_0140933 | Molecular function | 5'-(N(7)-methylguanosine 5'-triphospho)-[mRNA] hydrolase activity |
| GO_0106378 | Molecular function | 2-hydroxy-dATP hydrolase activity |
| GO_0047693 | Molecular function | ATP diphosphatase activity |
| GO_0008413 | Molecular function | 8-oxo-7,8-dihydroguanosine triphosphate pyrophosphatase activity |
| GO_0030515 | Molecular function | snoRNA binding |
| GO_0016818 | Molecular function | hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides |
| GO_0046872 | Molecular function | metal ion binding |
| GO_0008828 | Molecular function | dATP diphosphatase activity |
| GO_0005515 | Molecular function | protein binding |
| Gene name | NUDT1 |
| Protein name | Nudix hydrolase 1 Oxidized purine nucleoside triphosphate hydrolase (EC 3.6.1.56) (2-hydroxy-dATP diphosphatase) (7,8-dihydro-8-oxoguanine triphosphatase) (8-oxo-dGTPase) (Methylated purine nucleoside triphosphate hydrolase) (EC 3.6.1.-) (Nucleoside diphosphate-linked moiety X motif 1) (Nudix motif 1) |
| Synonyms | MTH1 |
| Description | FUNCTION: Oxidized purine nucleoside triphosphate hydrolase which is a prominent sanitizer of the oxidized nucleotide pool . Catalyzes the hydrolysis of 2-oxo-dATP (2-hydroxy-dATP) into 2-oxo-dAMP . Has also a significant hydrolase activity toward 2-oxo-ATP, 8-oxo-dGTP and 8-oxo-dATP . Through the hydrolysis of oxidized purine nucleoside triphosphates, prevents their incorporation into DNA and the subsequent transversions A:T to C:G and G:C to T:A . Also catalyzes the hydrolysis of methylated purine nucleoside triphosphate preventing their integration into DNA . Through this antimutagenic activity protects cells from oxidative stress . . |
| Accessions | ENST00000397049.2 [P36639-4] P36639 ENST00000397048.5 [P36639-2] C9J361 ENST00000397046.5 [P36639-4] ENST00000356714.6 [P36639-4] ENST00000339737.6 [P36639-4] ENST00000343985.8 [P36639-2] ENST00000454650.1 |
