NME4 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0006183Biological processGTP biosynthetic process
GO_0009116Biological processnucleoside metabolic process
GO_0006228Biological processUTP biosynthetic process
GO_0006241Biological processCTP biosynthetic process
GO_0006869Biological processlipid transport
GO_0005758Cellular componentmitochondrial intermembrane space
GO_0005759Cellular componentmitochondrial matrix
GO_0005743Cellular componentmitochondrial inner membrane
GO_0005739Cellular componentmitochondrion
GO_0004550Molecular functionnucleoside diphosphate kinase activity
GO_1901612Molecular functioncardiolipin binding
GO_0046872Molecular functionmetal ion binding
GO_0005515Molecular functionprotein binding
GO_0005524Molecular functionATP binding

IV. Literature review

[source]
Gene nameNME4
Protein nameNucleoside diphosphate kinase (EC 2.7.4.6)
NME/NM23 nucleoside diphosphate kinase 4
Nucleoside diphosphate kinase, mitochondrial (NDK) (NDP kinase, mitochondrial) (EC 2.7.4.6) (Nucleoside diphosphate kinase D) (NDPKD) (nm23-H4)
nucleoside-diphosphate kinase (EC 2.7.4.6)
SynonymsNM23D
DescriptionFUNCTION: Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate. Through the catalyzed exchange of gamma-phosphate between di- and triphosphonucleosides participates in regulation of intracellular nucleotide homeostasis . Binds to anionic phospholipids, predominantly to cardiolipin; the binding inhibits its phosphotransfer activity . Acts as a mitochondria-specific NDK; its association with cardiolipin-containing mitochondrial inner membrane is coupled to respiration suggesting that ADP locally regenerated in the mitochondrion innermembrane space by its activity is directly taken up via ANT ADP/ATP translocase into the matrix space to stimulate respiratory ATP regeneration . Proposed to increase GTP-loading on dynamin-related GTPase OPA1 in mitochondria . In vitro can induce liposome cross-linking suggesting that it can cross-link inner and outer membranes to form contact sites, and promotes intermembrane migration of anionic phosphoplipids. Promotes the redistribution of cardiolipin between the mitochondrial inner membrane and outer membrane which is implicated in pro-apoptotic signaling . .

AccessionsENST00000219479.7 [O00746-1]
ENST00000454619.5
ENST00000382940.8
ENST00000621774.4
H0Y6J0
ENST00000433358.5
ENST00000444498.5
ENST00000448828.5
ENST00000450036.1 [O00746-2]
A2IDC9
O00746
F2Z297
A0A087WVT9
Q4TT34
ENST00000620944.4 [O00746-2]
F2Z2X0
ENST00000397722.5 [O00746-2]