I. Expression across cell types
Name | Number of supported studies  | Average coverage | |
|---|---|---|---|
| enteroendocrine cell | 5 studies | 41% ± 18% | |
| oligodendrocyte | 5 studies | 23% ± 7% | |
| pancreatic A cell | 3 studies | 22% ± 4% | |
| oligodendrocyte precursor cell | 3 studies | 30% ± 7% |
Name | Number of supported studies | Average coverage | |
|---|---|---|---|
| enteroendocrine cell | 5 studies | 41% ± 18% | |
| oligodendrocyte | 5 studies | 23% ± 7% | |
| pancreatic A cell | 3 studies | 22% ± 4% | |
| oligodendrocyte precursor cell | 3 studies | 30% ± 7% |
Insufficient scRNA-seq data for expression of NKX2-2 at tissue level.
Tissue | GTEx Coverage | GTEx Average TPM | GTEx Number of samples | TCGA Coverage | TCGA Average TPM | TCGA Number of samples |
|---|---|---|---|---|---|---|
| brain | 100% | 434.17 | 2637 / 2642 | 98% | 19.55 | 693 / 705 |
| pancreas | 86% | 144.20 | 281 / 328 | 51% | 12.39 | 91 / 178 |
| stomach | 41% | 35.96 | 148 / 359 | 2% | 0.77 | 6 / 286 |
| skin | 0% | 0.19 | 6 / 1809 | 19% | 1.21 | 90 / 472 |
| breast | 0% | 0 | 0 / 459 | 13% | 0.88 | 145 / 1118 |
| prostate | 0% | 0 | 0 / 245 | 10% | 0.41 | 49 / 502 |
| intestine | 4% | 2.88 | 39 / 966 | 3% | 0.96 | 18 / 527 |
| tonsil | 0% | 0 | 0 / 0 | 7% | 0.69 | 3 / 45 |
| esophagus | 0% | 0 | 0 / 1445 | 6% | 1.34 | 11 / 183 |
| uterus | 1% | 0.35 | 1 / 170 | 5% | 2.03 | 22 / 459 |
| eye | 0% | 0 | 0 / 0 | 4% | 0.23 | 3 / 80 |
| lung | 0% | 0 | 0 / 578 | 3% | 0.25 | 33 / 1155 |
| liver | 0% | 0.21 | 1 / 226 | 2% | 0.08 | 7 / 406 |
| adrenal gland | 0% | 0.71 | 1 / 258 | 2% | 0.67 | 4 / 230 |
| bladder | 0% | 0 | 0 / 21 | 2% | 0.21 | 9 / 504 |
| kidney | 0% | 0 | 0 / 89 | 1% | 0.10 | 11 / 901 |
| ovary | 0% | 0 | 0 / 180 | 0% | 0.02 | 2 / 430 |
| thymus | 0% | 0 | 0 / 653 | 0% | 0.11 | 2 / 605 |
| adipose | 0% | 0.06 | 1 / 1204 | 0% | 0 | 0 / 0 |
| abdomen | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| blood vessel | 0% | 0 | 0 / 1335 | 0% | 0 | 0 / 0 |
| bone marrow | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| diaphragm | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| gingiva | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| heart | 0% | 0 | 0 / 861 | 0% | 0 | 0 / 0 |
| lymph node | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 29 |
| muscle | 0% | 0 | 0 / 803 | 0% | 0 | 0 / 0 |
| nasal cavity | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nasopharynx | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nose | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| peripheral blood | 0% | 0 | 0 / 929 | 0% | 0 | 0 / 0 |
| placenta | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| spinal column | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| spleen | 0% | 0 | 0 / 241 | 0% | 0 | 0 / 0 |
| ureter | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 1 |
| GO_0014003 | Biological process | oligodendrocyte development |
| GO_0003327 | Biological process | type B pancreatic cell fate commitment |
| GO_0007224 | Biological process | smoothened signaling pathway |
| GO_0009749 | Biological process | response to glucose |
| GO_0006357 | Biological process | regulation of transcription by RNA polymerase II |
| GO_0010628 | Biological process | positive regulation of gene expression |
| GO_0048665 | Biological process | neuron fate specification |
| GO_0021530 | Biological process | spinal cord oligodendrocyte cell fate specification |
| GO_0048708 | Biological process | astrocyte differentiation |
| GO_0003329 | Biological process | pancreatic PP cell fate commitment |
| GO_0021554 | Biological process | optic nerve development |
| GO_0060580 | Biological process | ventral spinal cord interneuron fate determination |
| GO_0061101 | Biological process | neuroendocrine cell differentiation |
| GO_0045665 | Biological process | negative regulation of neuron differentiation |
| GO_0030154 | Biological process | cell differentiation |
| GO_0048714 | Biological process | positive regulation of oligodendrocyte differentiation |
| GO_0003326 | Biological process | pancreatic A cell fate commitment |
| GO_0003323 | Biological process | type B pancreatic cell development |
| GO_0048565 | Biological process | digestive tract development |
| GO_0007420 | Biological process | brain development |
| GO_0045666 | Biological process | positive regulation of neuron differentiation |
| GO_0021522 | Biological process | spinal cord motor neuron differentiation |
| GO_0032570 | Biological process | response to progesterone |
| GO_0045944 | Biological process | positive regulation of transcription by RNA polymerase II |
| GO_0030858 | Biological process | positive regulation of epithelial cell differentiation |
| GO_0005654 | Cellular component | nucleoplasm |
| GO_0000785 | Cellular component | chromatin |
| GO_0005634 | Cellular component | nucleus |
| GO_0000978 | Molecular function | RNA polymerase II cis-regulatory region sequence-specific DNA binding |
| GO_0001228 | Molecular function | DNA-binding transcription activator activity, RNA polymerase II-specific |
| GO_0000981 | Molecular function | DNA-binding transcription factor activity, RNA polymerase II-specific |
| GO_0000987 | Molecular function | cis-regulatory region sequence-specific DNA binding |
| GO_0005515 | Molecular function | protein binding |
| Gene name | NKX2-2 |
| Protein name | Homeobox protein Nkx-2.2 (Homeobox protein NK-2 homolog B) |
| Synonyms | NKX2.2 NKX2B |
| Description | FUNCTION: Transcriptional activator involved in the development of insulin-producting beta cells in the endocrine pancreas (By similarity). May also be involved in specifying diencephalic neuromeric boundaries, and in controlling the expression of genes that play a role in axonal guidance. Binds to elements within the NEUROD1 promoter (By similarity). . |
| Accessions | O95096 ENST00000377142.5 |
