NGLY1 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0006517Biological processprotein deglycosylation
GO_0006457Biological processprotein folding
GO_0006516Biological processglycoprotein catabolic process
GO_0005829Cellular componentcytosol
GO_0005737Cellular componentcytoplasm
GO_0005634Cellular componentnucleus
GO_0000224Molecular functionpeptide-N4-(N-acetyl-beta-glucosaminyl)asparagine amidase activity
GO_0005515Molecular functionprotein binding
GO_0046872Molecular functionmetal ion binding

IV. Literature review

[source]
Gene nameNGLY1
Protein namePeptide-N(4)-(N-acetyl-beta-glucosaminyl)asparagine amidase (EC 3.5.1.52) (N-glycanase 1) (Peptide:N-glycanase)
Peptide-N(4)-(N-acetyl-beta-glucosaminyl)asparagine amidase (PNGase) (hPNGase) (EC 3.5.1.52) (N-glycanase 1) (Peptide:N-glycanase)
N-glycanase 1
N-glycanase 1, isoform CRA_c (cDNA FLJ11005 fis, clone PLACE1002996)
SynonymsPNG1
hCG_28354
DescriptionFUNCTION: Specifically deglycosylates the denatured form of N-linked glycoproteins in the cytoplasm and assists their proteasome-mediated degradation. Cleaves the beta-aspartyl-glucosamine (GlcNAc) of the glycan and the amide side chain of Asn, converting Asn to Asp. Prefers proteins containing high-mannose over those bearing complex type oligosaccharides. Can recognize misfolded proteins in the endoplasmic reticulum that are exported to the cytosol to be destroyed and deglycosylate them, while it has no activity toward native proteins. Deglycosylation is a prerequisite for subsequent proteasome-mediated degradation of some, but not all, misfolded glycoproteins. .

FUNCTION: Specifically deglycosylates the denatured form of N-linked glycoproteins in the cytoplasm and assists their proteasome-mediated degradation. Cleaves the beta-aspartyl-glucosamine (GlcNAc) of the glycan and the amide side chain of Asn, converting Asn to Asp. Prefers proteins containing high-mannose over those bearing complex type oligosaccharides. Can recognize misfolded proteins in the endoplasmic reticulum that are exported to the cytosol to be destroyed and deglycosylate them, while it has no activity toward native proteins. Deglycosylation is a prerequisite for subsequent proteasome-mediated degradation of some, but not all, misfolded glycoproteins. .

AccessionsENST00000675234.1
A0A6Q8PGC8
A0A6Q8PHJ3
ENST00000417874.6 [Q96IV0-5]
ENST00000675217.1
A0A6Q8PHH7
A0A6Q8PF23
A0A6Q8PFQ1
ENST00000675680.1
ENST00000427041.1
ENST00000396649.7 [Q96IV0-3]
Q9NV10
A0A0C4DFP4
C9JU75
H0Y2P2
ENST00000428257.5 [Q96IV0-2]
ENST00000280699.13
ENST00000463611.2
ENST00000308710.9
ENST00000676225.1
ENST00000280700.10 [Q96IV0-1]
Q96IV0