Name | Number of supported studies | Average coverage | |
---|---|---|---|
B cell | 24 studies | 24% ± 7% | |
plasmacytoid dendritic cell | 16 studies | 36% ± 10% | |
memory B cell | 14 studies | 20% ± 4% | |
naive B cell | 13 studies | 23% ± 5% | |
endothelial cell | 11 studies | 26% ± 8% | |
plasma cell | 10 studies | 30% ± 10% | |
natural killer cell | 9 studies | 19% ± 2% | |
CD16-negative, CD56-bright natural killer cell, human | 7 studies | 18% ± 2% | |
epithelial cell | 7 studies | 28% ± 9% | |
macrophage | 7 studies | 25% ± 9% | |
CD16-positive, CD56-dim natural killer cell, human | 6 studies | 18% ± 2% | |
microglial cell | 6 studies | 25% ± 6% | |
precursor B cell | 6 studies | 30% ± 7% | |
oligodendrocyte | 6 studies | 24% ± 6% | |
plasmablast | 5 studies | 45% ± 17% | |
GABAergic neuron | 5 studies | 44% ± 20% | |
astrocyte | 5 studies | 30% ± 10% | |
hematopoietic precursor cell | 4 studies | 25% ± 8% | |
pro-B cell | 4 studies | 28% ± 4% | |
myeloid cell | 4 studies | 21% ± 5% | |
immature B cell | 4 studies | 26% ± 5% | |
adipocyte | 4 studies | 19% ± 3% | |
lymphocyte | 4 studies | 25% ± 8% | |
glutamatergic neuron | 4 studies | 55% ± 20% | |
oligodendrocyte precursor cell | 4 studies | 33% ± 9% | |
dendritic cell | 4 studies | 30% ± 13% | |
leukocyte | 4 studies | 20% ± 2% | |
T cell | 4 studies | 18% ± 2% | |
endothelial cell of lymphatic vessel | 4 studies | 19% ± 2% | |
CD8-positive, alpha-beta memory T cell | 4 studies | 18% ± 2% | |
gamma-delta T cell | 4 studies | 23% ± 11% | |
effector memory CD8-positive, alpha-beta T cell | 3 studies | 20% ± 4% | |
mature NK T cell | 3 studies | 19% ± 3% | |
GABAergic interneuron | 3 studies | 16% ± 1% | |
ciliated cell | 3 studies | 19% ± 2% | |
fibroblast | 3 studies | 21% ± 4% | |
abnormal cell | 3 studies | 24% ± 5% | |
monocyte | 3 studies | 18% ± 2% | |
basal cell | 3 studies | 28% ± 7% | |
goblet cell | 3 studies | 25% ± 12% | |
transit amplifying cell | 3 studies | 26% ± 13% | |
neuron | 3 studies | 25% ± 11% | |
interneuron | 3 studies | 48% ± 20% |
Tissue | GTEx Coverage | GTEx Average TPM | GTEx Number of samples | TCGA Coverage | TCGA Average TPM | TCGA Number of samples |
---|---|---|---|---|---|---|
bladder | 100% | 1379.00 | 21 / 21 | 100% | 13.56 | 504 / 504 |
breast | 100% | 1589.53 | 459 / 459 | 100% | 14.36 | 1118 / 1118 |
lung | 100% | 1508.66 | 578 / 578 | 100% | 10.04 | 1155 / 1155 |
ovary | 100% | 1347.78 | 180 / 180 | 100% | 10.47 | 430 / 430 |
pancreas | 100% | 1271.62 | 328 / 328 | 100% | 9.78 | 178 / 178 |
uterus | 100% | 1227.79 | 170 / 170 | 100% | 11.83 | 459 / 459 |
intestine | 100% | 1586.29 | 966 / 966 | 100% | 11.78 | 526 / 527 |
prostate | 100% | 1591.44 | 245 / 245 | 100% | 15.17 | 501 / 502 |
liver | 100% | 1500.79 | 226 / 226 | 100% | 7.44 | 405 / 406 |
thymus | 100% | 1423.40 | 653 / 653 | 100% | 11.87 | 603 / 605 |
stomach | 100% | 1294.72 | 359 / 359 | 100% | 11.04 | 285 / 286 |
esophagus | 100% | 1256.42 | 1445 / 1445 | 99% | 8.10 | 182 / 183 |
skin | 100% | 1331.73 | 1808 / 1809 | 99% | 12.15 | 469 / 472 |
kidney | 100% | 1314.16 | 89 / 89 | 99% | 8.84 | 893 / 901 |
brain | 99% | 1084.94 | 2611 / 2642 | 100% | 11.10 | 705 / 705 |
adrenal gland | 100% | 1721.30 | 258 / 258 | 94% | 5.57 | 217 / 230 |
adipose | 100% | 1543.27 | 1204 / 1204 | 0% | 0 | 0 / 0 |
lymph node | 0% | 0 | 0 / 0 | 100% | 24.22 | 29 / 29 |
muscle | 100% | 3372.17 | 803 / 803 | 0% | 0 | 0 / 0 |
spleen | 100% | 2699.67 | 241 / 241 | 0% | 0 | 0 / 0 |
tonsil | 0% | 0 | 0 / 0 | 100% | 10.07 | 45 / 45 |
ureter | 0% | 0 | 0 / 0 | 100% | 3.65 | 1 / 1 |
blood vessel | 100% | 1267.97 | 1333 / 1335 | 0% | 0 | 0 / 0 |
peripheral blood | 99% | 2345.95 | 920 / 929 | 0% | 0 | 0 / 0 |
heart | 97% | 1285.32 | 837 / 861 | 0% | 0 | 0 / 0 |
eye | 0% | 0 | 0 / 0 | 86% | 4.74 | 69 / 80 |
abdomen | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
bone marrow | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
diaphragm | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
gingiva | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
nasal cavity | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
nasopharynx | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
nose | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
placenta | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
spinal column | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
GO_0006517 | Biological process | protein deglycosylation |
GO_0006457 | Biological process | protein folding |
GO_0006516 | Biological process | glycoprotein catabolic process |
GO_0005829 | Cellular component | cytosol |
GO_0005737 | Cellular component | cytoplasm |
GO_0005634 | Cellular component | nucleus |
GO_0000224 | Molecular function | peptide-N4-(N-acetyl-beta-glucosaminyl)asparagine amidase activity |
GO_0005515 | Molecular function | protein binding |
GO_0046872 | Molecular function | metal ion binding |
Gene name | NGLY1 |
Protein name | Peptide-N(4)-(N-acetyl-beta-glucosaminyl)asparagine amidase (EC 3.5.1.52) (N-glycanase 1) (Peptide:N-glycanase) Peptide-N(4)-(N-acetyl-beta-glucosaminyl)asparagine amidase (PNGase) (hPNGase) (EC 3.5.1.52) (N-glycanase 1) (Peptide:N-glycanase) N-glycanase 1 N-glycanase 1, isoform CRA_c (cDNA FLJ11005 fis, clone PLACE1002996) |
Synonyms | PNG1 hCG_28354 |
Description | FUNCTION: Specifically deglycosylates the denatured form of N-linked glycoproteins in the cytoplasm and assists their proteasome-mediated degradation. Cleaves the beta-aspartyl-glucosamine (GlcNAc) of the glycan and the amide side chain of Asn, converting Asn to Asp. Prefers proteins containing high-mannose over those bearing complex type oligosaccharides. Can recognize misfolded proteins in the endoplasmic reticulum that are exported to the cytosol to be destroyed and deglycosylate them, while it has no activity toward native proteins. Deglycosylation is a prerequisite for subsequent proteasome-mediated degradation of some, but not all, misfolded glycoproteins. . FUNCTION: Specifically deglycosylates the denatured form of N-linked glycoproteins in the cytoplasm and assists their proteasome-mediated degradation. Cleaves the beta-aspartyl-glucosamine (GlcNAc) of the glycan and the amide side chain of Asn, converting Asn to Asp. Prefers proteins containing high-mannose over those bearing complex type oligosaccharides. Can recognize misfolded proteins in the endoplasmic reticulum that are exported to the cytosol to be destroyed and deglycosylate them, while it has no activity toward native proteins. Deglycosylation is a prerequisite for subsequent proteasome-mediated degradation of some, but not all, misfolded glycoproteins. . |
Accessions | ENST00000675234.1 A0A6Q8PGC8 A0A6Q8PHJ3 ENST00000417874.6 [Q96IV0-5] ENST00000675217.1 A0A6Q8PHH7 A0A6Q8PF23 A0A6Q8PFQ1 ENST00000675680.1 ENST00000427041.1 ENST00000396649.7 [Q96IV0-3] Q9NV10 A0A0C4DFP4 C9JU75 H0Y2P2 ENST00000428257.5 [Q96IV0-2] ENST00000280699.13 ENST00000463611.2 ENST00000308710.9 ENST00000676225.1 ENST00000280700.10 [Q96IV0-1] Q96IV0 |