NEDD4L report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0016567Biological processprotein ubiquitination
GO_0042391Biological processregulation of membrane potential
GO_0048814Biological processregulation of dendrite morphogenesis
GO_1901380Biological processnegative regulation of potassium ion transmembrane transport
GO_0034220Biological processmonoatomic ion transmembrane transport
GO_0006511Biological processubiquitin-dependent protein catabolic process
GO_0086005Biological processventricular cardiac muscle cell action potential
GO_1903861Biological processpositive regulation of dendrite extension
GO_1901016Biological processregulation of potassium ion transmembrane transporter activity
GO_1902306Biological processnegative regulation of sodium ion transmembrane transport
GO_0003254Biological processregulation of membrane depolarization
GO_0034765Biological processregulation of monoatomic ion transmembrane transport
GO_0060306Biological processregulation of membrane repolarization
GO_0045732Biological processpositive regulation of protein catabolic process
GO_0070936Biological processprotein K48-linked ubiquitination
GO_0030154Biological processcell differentiation
GO_2001288Biological processpositive regulation of caveolin-mediated endocytosis
GO_2000009Biological processnegative regulation of protein localization to cell surface
GO_1901017Biological processnegative regulation of potassium ion transmembrane transporter activity
GO_0006513Biological processprotein monoubiquitination
GO_2000650Biological processnegative regulation of sodium ion transmembrane transporter activity
GO_1902305Biological processregulation of sodium ion transmembrane transport
GO_0043161Biological processproteasome-mediated ubiquitin-dependent protein catabolic process
GO_0031647Biological processregulation of protein stability
GO_0005886Cellular componentplasma membrane
GO_0070062Cellular componentextracellular exosome
GO_0005654Cellular componentnucleoplasm
GO_0005794Cellular componentGolgi apparatus
GO_0005829Cellular componentcytosol
GO_0005771Cellular componentmultivesicular body
GO_0005737Cellular componentcytoplasm
GO_0061630Molecular functionubiquitin protein ligase activity
GO_0019871Molecular functionsodium channel inhibitor activity
GO_0019870Molecular functionpotassium channel inhibitor activity
GO_0015459Molecular functionpotassium channel regulator activity
GO_0044325Molecular functiontransmembrane transporter binding
GO_0004842Molecular functionubiquitin-protein transferase activity
GO_0017080Molecular functionsodium channel regulator activity
GO_0005515Molecular functionprotein binding

IV. Literature review

[source]
Gene nameNEDD4L
Protein nameE3 ubiquitin-protein ligase (EC 2.3.2.26)
HECT-type E3 ubiquitin transferase (EC 2.3.2.26)
NEDD4 like E3 ubiquitin protein ligase
NEDD4-2 minus WW2,3 variant
E3 ubiquitin-protein ligase NEDD4-like (EC 2.3.2.26) (EC 2.3.2.36) (HECT-type E3 ubiquitin transferase NED4L) (NEDD4.2) (Nedd4-2)
SynonymsNEDL3
KIAA0439
DescriptionFUNCTION: E3 ubiquitin-protein ligase that mediates the polyubiquitination of lysine and cysteine residues on target proteins and is thereby implicated in the regulation of various signaling pathways including autophagy, innate immunity or DNA repair . Inhibits TGF-beta signaling by triggering SMAD2 and TGFBR1 ubiquitination and proteasome-dependent degradation . Downregulates autophagy and cell growth by ubiquitinating and reducing cellular ULK1 or ASCT2 levels . Promotes ubiquitination and internalization of various plasma membrane channels such as ENaC, SCN2A/Nav1.2, SCN3A/Nav1.3, SCN5A/Nav1.5, SCN9A/Nav1.7, SCN10A/Nav1.8, KCNA3/Kv1.3, KCNH2, EAAT1, KCNQ2/Kv7.2, KCNQ3/Kv7.3 or CLC5 . Promotes ubiquitination and degradation of SGK1 and TNK2. Ubiquitinates BRAT1 and this ubiquitination is enhanced in the presence of NDFIP1 . Plays a role in dendrite formation by melanocytes . Involved in the regulation of TOR signaling . Ubiquitinates and regulates protein levels of NTRK1 once this one is activated by NGF . Plays a role in antiviral innate immunity by catalyzing 'Lys-29'-linked cysteine ubiquitination of TRAF3, resulting in enhanced 'Lys-48' and 'Lys-63'-linked ubiquitination of TRAF3 . .

AccessionsENST00000587190.5
A0A1B0GVY1
ENST00000587881.1
ENST00000675221.1
ENST00000674517.1 [Q96PU5-9]
ENST00000675865.1 [Q96PU5-9]
K7ENS6
ENST00000617539.1
Q5XLQ3
ENST00000456173.6 [Q96PU5-9]
A0A140TA85
ENST00000588494.5
ENST00000435432.6 [Q96PU5-9]
ENST00000679791.1
ENST00000357895.9 [Q96PU5-7]
A0A6Q8PG51
ENST00000676024.1
ENST00000674845.1
ENST00000589054.5
ENST00000431212.6 [Q96PU5-4]
ENST00000676223.1
A0A6Q8PHE7
K7EN51
ENST00000635997.1
K7EQC5
A0A7P0Z498
ENST00000675101.1
A0A6Q8PGL4
Q96PU5
ENST00000586268.5
ENST00000676226.1 [Q96PU5-9]
ENST00000256830.13 [Q96PU5-3]
K7EKL1
ENST00000586263.5 [Q96PU5-6]
ENST00000400345.8 [Q96PU5-1]
A0A087WVI6
ENST00000675227.1
ENST00000382850.8 [Q96PU5-5]
K7ERN1
ENST00000675801.1 [Q96PU5-9]
A0A6Q8PHJ5
ENST00000675147.1
ENST00000592846.5
ENST00000675502.1 [Q96PU5-9]
A0A6Q8PG81
ENST00000456986.5 [Q96PU5-4]
ENST00000356462.10 [Q96PU5-2]
A0A6Q8PFI7
A0A6Q8PGP5