Name | Number of supported studies | Average coverage | |
---|---|---|---|
endothelial cell | 18 studies | 36% ± 18% | |
ciliated cell | 17 studies | 43% ± 17% | |
astrocyte | 14 studies | 39% ± 17% | |
glutamatergic neuron | 13 studies | 64% ± 22% | |
epithelial cell | 13 studies | 37% ± 18% | |
basal cell | 13 studies | 39% ± 22% | |
type I pneumocyte | 12 studies | 71% ± 19% | |
oligodendrocyte | 12 studies | 28% ± 10% | |
type II pneumocyte | 11 studies | 54% ± 24% | |
microglial cell | 11 studies | 40% ± 12% | |
GABAergic neuron | 10 studies | 58% ± 19% | |
goblet cell | 9 studies | 43% ± 22% | |
neuron | 8 studies | 48% ± 21% | |
macrophage | 8 studies | 31% ± 16% | |
club cell | 8 studies | 63% ± 24% | |
renal alpha-intercalated cell | 7 studies | 66% ± 19% | |
interneuron | 7 studies | 64% ± 20% | |
retinal ganglion cell | 7 studies | 72% ± 20% | |
retinal cone cell | 7 studies | 78% ± 17% | |
adipocyte | 7 studies | 32% ± 10% | |
ionocyte | 6 studies | 45% ± 16% | |
amacrine cell | 6 studies | 50% ± 18% | |
retina horizontal cell | 6 studies | 52% ± 23% | |
epithelial cell of proximal tubule | 5 studies | 37% ± 23% | |
kidney loop of Henle epithelial cell | 5 studies | 41% ± 22% | |
cardiac muscle cell | 5 studies | 31% ± 6% | |
mesothelial cell | 5 studies | 30% ± 9% | |
respiratory goblet cell | 5 studies | 52% ± 25% | |
secretory cell | 5 studies | 29% ± 10% | |
squamous epithelial cell | 4 studies | 35% ± 26% | |
cholangiocyte | 4 studies | 59% ± 21% | |
hepatocyte | 4 studies | 45% ± 31% | |
granule cell | 4 studies | 59% ± 4% | |
oligodendrocyte precursor cell | 4 studies | 21% ± 4% | |
pericyte | 4 studies | 35% ± 23% | |
capillary endothelial cell | 4 studies | 33% ± 18% | |
retinal pigment epithelial cell | 4 studies | 58% ± 24% | |
Mueller cell | 4 studies | 40% ± 12% | |
luminal hormone-sensing cell of mammary gland | 4 studies | 35% ± 9% | |
luminal cell of prostate epithelium | 4 studies | 47% ± 15% | |
fibroblast | 4 studies | 24% ± 14% | |
endothelial cell of lymphatic vessel | 4 studies | 29% ± 17% | |
renal principal cell | 4 studies | 53% ± 21% | |
GABAergic interneuron | 3 studies | 60% ± 15% | |
progenitor cell | 3 studies | 53% ± 28% | |
serous secreting cell | 3 studies | 21% ± 1% | |
GABAergic amacrine cell | 3 studies | 63% ± 7% | |
glycinergic amacrine cell | 3 studies | 51% ± 7% | |
acinar cell | 3 studies | 33% ± 15% | |
pancreatic A cell | 3 studies | 20% ± 3% | |
pancreatic ductal cell | 3 studies | 46% ± 12% | |
neural progenitor cell | 3 studies | 36% ± 17% | |
brush cell | 3 studies | 23% ± 1% | |
myoepithelial cell | 3 studies | 51% ± 19% | |
kidney distal convoluted tubule epithelial cell | 3 studies | 58% ± 23% | |
mucus secreting cell | 3 studies | 44% ± 13% |
Tissue | GTEx Coverage | GTEx Average TPM | GTEx Number of samples | TCGA Coverage | TCGA Average TPM | TCGA Number of samples |
---|---|---|---|---|---|---|
prostate | 99% | 11036.18 | 242 / 245 | 100% | 46.17 | 502 / 502 |
lung | 100% | 7508.08 | 577 / 578 | 99% | 9.91 | 1141 / 1155 |
kidney | 100% | 6699.43 | 89 / 89 | 98% | 10.44 | 882 / 901 |
intestine | 100% | 5265.86 | 965 / 966 | 98% | 6.16 | 515 / 527 |
stomach | 99% | 6325.57 | 354 / 359 | 98% | 7.39 | 281 / 286 |
thymus | 100% | 2752.66 | 650 / 653 | 95% | 6.85 | 576 / 605 |
pancreas | 100% | 3918.65 | 328 / 328 | 92% | 4.83 | 164 / 178 |
esophagus | 88% | 1917.99 | 1271 / 1445 | 99% | 9.35 | 181 / 183 |
bladder | 90% | 3347.38 | 19 / 21 | 95% | 7.29 | 479 / 504 |
breast | 89% | 2790.06 | 408 / 459 | 95% | 9.11 | 1066 / 1118 |
brain | 97% | 4900.53 | 2559 / 2642 | 79% | 3.66 | 559 / 705 |
liver | 83% | 1429.82 | 187 / 226 | 88% | 4.78 | 357 / 406 |
skin | 73% | 1386.40 | 1314 / 1809 | 96% | 13.21 | 452 / 472 |
uterus | 77% | 963.34 | 131 / 170 | 90% | 5.63 | 415 / 459 |
ovary | 59% | 730.69 | 107 / 180 | 74% | 3.10 | 317 / 430 |
adrenal gland | 99% | 2331.87 | 256 / 258 | 31% | 0.98 | 72 / 230 |
eye | 0% | 0 | 0 / 0 | 100% | 15.87 | 80 / 80 |
ureter | 0% | 0 | 0 / 0 | 100% | 3.72 | 1 / 1 |
muscle | 100% | 4420.30 | 801 / 803 | 0% | 0 | 0 / 0 |
tonsil | 0% | 0 | 0 / 0 | 93% | 7.74 | 42 / 45 |
heart | 93% | 2494.48 | 797 / 861 | 0% | 0 | 0 / 0 |
lymph node | 0% | 0 | 0 / 0 | 79% | 4.90 | 23 / 29 |
adipose | 75% | 1109.08 | 906 / 1204 | 0% | 0 | 0 / 0 |
spleen | 71% | 678.33 | 171 / 241 | 0% | 0 | 0 / 0 |
peripheral blood | 33% | 554.30 | 309 / 929 | 0% | 0 | 0 / 0 |
blood vessel | 7% | 67.29 | 87 / 1335 | 0% | 0 | 0 / 0 |
abdomen | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
bone marrow | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
diaphragm | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
gingiva | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
nasal cavity | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
nasopharynx | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
nose | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
placenta | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
spinal column | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
GO_0016567 | Biological process | protein ubiquitination |
GO_0042391 | Biological process | regulation of membrane potential |
GO_0048814 | Biological process | regulation of dendrite morphogenesis |
GO_1901380 | Biological process | negative regulation of potassium ion transmembrane transport |
GO_0034220 | Biological process | monoatomic ion transmembrane transport |
GO_0006511 | Biological process | ubiquitin-dependent protein catabolic process |
GO_0086005 | Biological process | ventricular cardiac muscle cell action potential |
GO_1903861 | Biological process | positive regulation of dendrite extension |
GO_1901016 | Biological process | regulation of potassium ion transmembrane transporter activity |
GO_1902306 | Biological process | negative regulation of sodium ion transmembrane transport |
GO_0003254 | Biological process | regulation of membrane depolarization |
GO_0034765 | Biological process | regulation of monoatomic ion transmembrane transport |
GO_0060306 | Biological process | regulation of membrane repolarization |
GO_0045732 | Biological process | positive regulation of protein catabolic process |
GO_0070936 | Biological process | protein K48-linked ubiquitination |
GO_0030154 | Biological process | cell differentiation |
GO_2001288 | Biological process | positive regulation of caveolin-mediated endocytosis |
GO_2000009 | Biological process | negative regulation of protein localization to cell surface |
GO_1901017 | Biological process | negative regulation of potassium ion transmembrane transporter activity |
GO_0006513 | Biological process | protein monoubiquitination |
GO_2000650 | Biological process | negative regulation of sodium ion transmembrane transporter activity |
GO_1902305 | Biological process | regulation of sodium ion transmembrane transport |
GO_0043161 | Biological process | proteasome-mediated ubiquitin-dependent protein catabolic process |
GO_0031647 | Biological process | regulation of protein stability |
GO_0005886 | Cellular component | plasma membrane |
GO_0070062 | Cellular component | extracellular exosome |
GO_0005654 | Cellular component | nucleoplasm |
GO_0005794 | Cellular component | Golgi apparatus |
GO_0005829 | Cellular component | cytosol |
GO_0005771 | Cellular component | multivesicular body |
GO_0005737 | Cellular component | cytoplasm |
GO_0061630 | Molecular function | ubiquitin protein ligase activity |
GO_0019871 | Molecular function | sodium channel inhibitor activity |
GO_0019870 | Molecular function | potassium channel inhibitor activity |
GO_0015459 | Molecular function | potassium channel regulator activity |
GO_0044325 | Molecular function | transmembrane transporter binding |
GO_0004842 | Molecular function | ubiquitin-protein transferase activity |
GO_0017080 | Molecular function | sodium channel regulator activity |
GO_0005515 | Molecular function | protein binding |
Gene name | NEDD4L |
Protein name | E3 ubiquitin-protein ligase (EC 2.3.2.26) HECT-type E3 ubiquitin transferase (EC 2.3.2.26) NEDD4 like E3 ubiquitin protein ligase NEDD4-2 minus WW2,3 variant E3 ubiquitin-protein ligase NEDD4-like (EC 2.3.2.26) (EC 2.3.2.36) (HECT-type E3 ubiquitin transferase NED4L) (NEDD4.2) (Nedd4-2) |
Synonyms | NEDL3 KIAA0439 |
Description | FUNCTION: E3 ubiquitin-protein ligase that mediates the polyubiquitination of lysine and cysteine residues on target proteins and is thereby implicated in the regulation of various signaling pathways including autophagy, innate immunity or DNA repair . Inhibits TGF-beta signaling by triggering SMAD2 and TGFBR1 ubiquitination and proteasome-dependent degradation . Downregulates autophagy and cell growth by ubiquitinating and reducing cellular ULK1 or ASCT2 levels . Promotes ubiquitination and internalization of various plasma membrane channels such as ENaC, SCN2A/Nav1.2, SCN3A/Nav1.3, SCN5A/Nav1.5, SCN9A/Nav1.7, SCN10A/Nav1.8, KCNA3/Kv1.3, KCNH2, EAAT1, KCNQ2/Kv7.2, KCNQ3/Kv7.3 or CLC5 . Promotes ubiquitination and degradation of SGK1 and TNK2. Ubiquitinates BRAT1 and this ubiquitination is enhanced in the presence of NDFIP1 . Plays a role in dendrite formation by melanocytes . Involved in the regulation of TOR signaling . Ubiquitinates and regulates protein levels of NTRK1 once this one is activated by NGF . Plays a role in antiviral innate immunity by catalyzing 'Lys-29'-linked cysteine ubiquitination of TRAF3, resulting in enhanced 'Lys-48' and 'Lys-63'-linked ubiquitination of TRAF3 . . |
Accessions | ENST00000587190.5 A0A1B0GVY1 ENST00000587881.1 ENST00000675221.1 ENST00000674517.1 [Q96PU5-9] ENST00000675865.1 [Q96PU5-9] K7ENS6 ENST00000617539.1 Q5XLQ3 ENST00000456173.6 [Q96PU5-9] A0A140TA85 ENST00000588494.5 ENST00000435432.6 [Q96PU5-9] ENST00000679791.1 ENST00000357895.9 [Q96PU5-7] A0A6Q8PG51 ENST00000676024.1 ENST00000674845.1 ENST00000589054.5 ENST00000431212.6 [Q96PU5-4] ENST00000676223.1 A0A6Q8PHE7 K7EN51 ENST00000635997.1 K7EQC5 A0A7P0Z498 ENST00000675101.1 A0A6Q8PGL4 Q96PU5 ENST00000586268.5 ENST00000676226.1 [Q96PU5-9] ENST00000256830.13 [Q96PU5-3] K7EKL1 ENST00000586263.5 [Q96PU5-6] ENST00000400345.8 [Q96PU5-1] A0A087WVI6 ENST00000675227.1 ENST00000382850.8 [Q96PU5-5] K7ERN1 ENST00000675801.1 [Q96PU5-9] A0A6Q8PHJ5 ENST00000675147.1 ENST00000592846.5 ENST00000675502.1 [Q96PU5-9] A0A6Q8PG81 ENST00000456986.5 [Q96PU5-4] ENST00000356462.10 [Q96PU5-2] A0A6Q8PFI7 A0A6Q8PGP5 |