NCOA6 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0007507Biological processheart development
GO_0006974Biological processDNA damage response
GO_0009725Biological processresponse to hormone
GO_0045893Biological processpositive regulation of DNA-templated transcription
GO_0030099Biological processmyeloid cell differentiation
GO_0007420Biological processbrain development
GO_0006352Biological processDNA-templated transcription initiation
GO_0045944Biological processpositive regulation of transcription by RNA polymerase II
GO_0035097Cellular componenthistone methyltransferase complex
GO_0005654Cellular componentnucleoplasm
GO_0005829Cellular componentcytosol
GO_0044666Cellular componentMLL3/4 complex
GO_0043231Cellular componentintracellular membrane-bounded organelle
GO_0005667Cellular componenttranscription regulator complex
GO_0005634Cellular componentnucleus
GO_0046966Molecular functionnuclear thyroid hormone receptor binding
GO_0019899Molecular functionenzyme binding
GO_0003682Molecular functionchromatin binding
GO_0030331Molecular functionnuclear estrogen receptor binding
GO_0046965Molecular functionnuclear retinoid X receptor binding
GO_0003713Molecular functiontranscription coactivator activity
GO_0030374Molecular functionnuclear receptor coactivator activity
GO_0005515Molecular functionprotein binding

IV. Literature review

[source]
Gene nameNCOA6
Protein nameNuclear receptor coactivator 6
Nuclear receptor coactivator-6 gamma
Nuclear receptor coactivator 6 (Nuclear receptor coactivator-6 delta)
Nuclear receptor coactivator 6 (Nuclear receptor coactivator-6 beta)
Nuclear receptor coactivator 6 (Activating signal cointegrator 2) (ASC-2) (Amplified in breast cancer protein 3) (Cancer-amplified transcriptional coactivator ASC-2) (Nuclear receptor coactivator RAP250) (NRC RAP250) (Nuclear receptor-activating protein, 250 kDa) (Peroxisome proliferator-activated receptor-interacting protein) (PPAR-interacting protein) (PRIP) (Thyroid hormone receptor-binding protein)
NCOA6 protein
SynonymsAIB3
TRBP
RAP250
KIAA0181
DescriptionFUNCTION: Nuclear receptor coactivator that directly binds nuclear receptors and stimulates the transcriptional activities in a hormone-dependent fashion. Coactivates expression in an agonist- and AF2-dependent manner. Involved in the coactivation of different nuclear receptors, such as for steroids (GR and ERs), retinoids (RARs and RXRs), thyroid hormone (TRs), vitamin D3 (VDR) and prostanoids (PPARs). Probably functions as a general coactivator, rather than just a nuclear receptor coactivator. May also be involved in the coactivation of the NF-kappa-B pathway. May coactivate expression via a remodeling of chromatin and its interaction with histone acetyltransferase proteins.

AccessionsQ1RMZ3
ENST00000359003.7
Q14686
F6M2K2
ENST00000616167.1
F6M2K3
ENST00000374796.6
A0A0D9SFT8
ENST00000628752.2
F6M2K4
ENST00000612493.4